CARE4Kids: Imaging Biomarker Core

CARE4Kids:成像生物标志物核心

基本信息

  • 批准号:
    10203601
  • 负责人:
  • 金额:
    $ 23.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-08 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT – Imaging Biomarker Core The CARE4Kids Center Without Walls Project aims to discover measurable biomarkers of persistent post- concussive symptoms (PPCS) and use these markers to characterize subgroups (endophenotypes) that will inform prognosis and potential treatment. Advanced neuroimaging offers great promise in revealing how concussion affects brain structure and function, but relatively small sample sizes have limited the reliability and generalizability of imaging studies to date. The overall goal of the Imaging Biomarker Core is to collect state-of- the-art multimodal brain imaging data that is maximally informative about outcomes in children and adolescents with concussion. Multimodal imaging will be collected in the Development Cohort, at baseline only, and used to develop and test models of outcome prediction that will be examined in the Validation Cohort. The neuroimaging protocol is designed to maximize data quality and minimize discomfort for our injured, younger patient population and is based on existing multi-site efforts (i.e., ABCD, UK Biobank) and NINDS imaging recommendations. The Imaging Biomarker Core has the following Specific Aims: Specific Aim 1: Discover which multimodal brain imaging measures best predict clinical outcomes in concussion (separately, and when combined with other biomarkers and clinical measures). Specific Aim 2: Neuroimaging site qualification and training – site qualification using pilot data and coordinated training will prepare sites to collect high-quality data. Specific Aim 3: Collect high-quality multimodal brain MRI – 360 participants will be scanned across 6 sites in the Development Cohort. Specific Aim 4: Ongoing data quality control – ongoing quality control through phantoms, volunteers, and data review will ensure high-quality data that is maximally comparable across sites. Specific Aim 5: Analyze Data: Transfer images and derived measures to the University of Utah Data Coordinating Center (U-DCC) to disseminate to the research community. We will use standardized, validated, publicly-available protocols to process the neuroimaging data. Measures of regional brain volumes, cortical geometry, white matter organization, functional connectivity, perfusion, and neuropathology (i.e., microbleeds and white matter hyperintensities) will be compared between groups and examined for correlation with outcome measures. In addition to these simpler approaches, working with the U-DCC, we will employ machine learning approaches to identify which combination of imaging, demographic, and clinical measures best predicts functional outcome.
项目摘要/摘要-成像生物标志物核心

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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PAUL M THOMPSON其他文献

PAUL M THOMPSON的其他文献

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{{ truncateString('PAUL M THOMPSON', 18)}}的其他基金

ENIGMA World Aging Center
ENIGMA世界老龄化中心
  • 批准号:
    10576402
  • 财政年份:
    2021
  • 资助金额:
    $ 23.01万
  • 项目类别:
ENIGMA World Aging Center
ENIGMA世界老龄化中心
  • 批准号:
    10328963
  • 财政年份:
    2021
  • 资助金额:
    $ 23.01万
  • 项目类别:
FiberNET: Deep learning to evaluate brain tract integrity worldwide and in AD
FiberNET:深度学习评估全球和 AD 脑道完整性
  • 批准号:
    10814696
  • 财政年份:
    2020
  • 资助金额:
    $ 23.01万
  • 项目类别:
Neuroimaging Core
神经影像核心
  • 批准号:
    10216924
  • 财政年份:
    2018
  • 资助金额:
    $ 23.01万
  • 项目类别:
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA
ENIGMA-SD:通过 ENIGMA 了解全球心理健康中的性别差异
  • 批准号:
    9892045
  • 财政年份:
    2018
  • 资助金额:
    $ 23.01万
  • 项目类别:
Neuroimaging Core
神经影像核心
  • 批准号:
    10456750
  • 财政年份:
    2018
  • 资助金额:
    $ 23.01万
  • 项目类别:
Multi-Source Sparse Learning to Identify MCI and Predict Decline
多源稀疏学习识别 MCI 并预测衰退
  • 批准号:
    9008380
  • 财政年份:
    2016
  • 资助金额:
    $ 23.01万
  • 项目类别:
Data Science Research
数据科学研究
  • 批准号:
    9108711
  • 财政年份:
    2016
  • 资助金额:
    $ 23.01万
  • 项目类别:
ENIGMA Center for Worldwide Medicine, Imaging & Genomics
ENIGMA 全球医学影像中心
  • 批准号:
    9108710
  • 财政年份:
    2014
  • 资助金额:
    $ 23.01万
  • 项目类别:
Growth factors, neuroinflammation, exercise, and brain integrity
生长因子、神经炎症、运动和大脑完整性
  • 批准号:
    8696676
  • 财政年份:
    2014
  • 资助金额:
    $ 23.01万
  • 项目类别:

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