Data Science Research

数据科学研究

• 批准号: 9108711
• 负责人: PAUL M THOMPSON
• 金额: $ 179.22万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2018-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108711
• 关键词: AIDS/HIV problem; Affect; Algorithms; Attention deficit hyperactivity disorder; Autistic Disorder; Big Data; Biological Markers; Bipolar Disorder; Brain; Brain Diseases; Brain Mapping; Brain imaging; Clinical; Collaborations; Combinatorics; Computer software; Computers; Country; Data; Data Science; Data Set; Diagnosis; Diagnostic and Statistical Manual of Mental Disorders; Diffusion; Disease; Economics; Genes; Genetic; Genetic Markers; Genetic screening method; Genome; Genomics; Goals; HIV; Hippocampus (Brain); Image; Institution; Lead; Learning; Link; MRI Scans; Machine Learning; Major Depressive Disorder; Maps; Mathematics; Measures; Medicine; Mental Depression; Meta-Analysis; Mining; Modeling; Movement; Multimodal Imaging; Pattern; Pharmaceutical Preparations; Research; Resources; Savings; Schizophrenia; Science; Site; Testing; Variant; Work; addiction; biomarker discovery; brain tissue; brain volume; chromosome 22q deletion syndrome; clinical biomarkers; cohort; computer infrastructure; connectome; cost effective; disease diagnosis; disorder risk; gene discovery; genetic variant; genome wide association study; genome-wide analysis; genomic biomarker; imaging modality; innovation; lifestyle factors; multitask; neuroimaging; new therapeutic target; novel; outcome forecast; predictive modeling; programs; risk variant; screening; search engine; tool; working group

Our comprehensive Data Science Research program is organized into 4 complementary Algorithm Research Cores: (1) Imaging Genomics, (2) Connectomics, (3) Machine Learning & Clinical Prediction, and (4) ENIGMA Disease Working Groups. World leaders in each field lead each Core, tackling computational questions on a scale not previously imagined or attempted. BigData tools will fuel ENIGMA'S worldwide scientific discoveries. We combine innovations in mathematics, machine learning, genomics, consortium science, and expertise from >20 countries and >125 institutions. ENIGMA is not a project, it is a scientific movement of rapidly and constantly Interacting collaborations that support each other. ENIGMA cohorts boost each other's power with gigantic datasets, tools and expertise to maximally exploit each other's data, performing some of the world's largest disease studies, beyond what any one site could perform alone. ENIGMA is distributed computation at its best, drawing on gigantic datasets and expertise. We create massive economic savings - drawing on worldwide computational and infrastructural resources vastly beyond what any one site in any one country would apply to a targeted biomedical goal. We bring BigData Science and the ENIGMA Consortium together to advance Worldwide Medicine. In Cores 1 and 2 we mine images and connectomes for genetic markers that re-wire the brain or boost brain tissue loss, using new mathematics to prioritize and organize trillions of computations, jointly searching images and genomes. In Core 3, we unleash multi-task sparse learning to predict diagnosis and prognosis from vast high-dimensional biomarker data in the largest neuroimaging genetics datasets ever. In Core 4 we use these tools in a massive distributed computation: a vast, mutually interacting set of 9 Worldwide Working Groups, led by experts in 9 major diseases of the brain - schizophrenia, bipolar, major depression, ADHD, autism, OCD, 22q deletion syndrome, HIV/AIDS, and addictions. We will discover what genes, medications, and lifestyle factors promote or resist brain disease worldwide. Our ENIGMA Center is a worldwide movement in mutually supportive discovery in medicine - spurred on by tools to perform gigantic computations never before Imagined.

我们全面的数据科学研究计划分为4个互补的算法研究 核心：（1）成像基因组学，（2）连接组学，（3）机器学习和临床预测，（4）ENIGMA 疾病工作组。每个领域的世界领导者领导着每个核心，在一个 以前没有想象或尝试过的规模。大数据工具将推动ENIGMA的全球科学发现。 我们将联合收割机在数学、机器学习、基因组学、联盟科学方面的创新和来自 >20个国家和>125个机构。ENIGMA不是一个项目，它是一个科学运动， 不断相互支持的互动协作。ENIGMA的同伙们互相增强力量， 巨大的数据集，工具和专业知识，以最大限度地利用彼此的数据，执行一些世界上 最大的疾病研究，超出了任何一个网站可以单独执行。ENIGMA是分布式计算， 它是最好的，利用巨大的数据集和专业知识。我们创造了大量的经济储蓄-利用 世界范围内的计算和基础设施资源远远超过任何一个国家的任何一个站点 将适用于有针对性的生物医学目标。我们将BigData Science和ENIGMA Consortium结合在一起 推动世界医学的发展在核心1和2中，我们挖掘图像和连接体的遗传标记， 重新连接大脑或促进脑组织的损失，使用新的数学来优先考虑和组织数万亿 计算，联合搜索图像和基因组。在Core 3中，我们释放了多任务稀疏学习， 从最大的神经成像系统中的大量高维生物标志物数据预测诊断和预后 遗传学数据集。在Core 4中，我们在大规模分布式计算中使用这些工具： 由9个全球工作组组成的互动组，由9种主要脑部疾病-精神分裂症， 躁郁症、重度抑郁症、多动症、自闭症、强迫症、22 q缺失综合征、艾滋病毒/艾滋病和成瘾。我们将 发现哪些基因，药物和生活方式因素促进或抵抗世界各地的脑部疾病。我们 ENIGMA中心是一个在医学上相互支持的发现的全球性运动-由工具推动 来进行从未想象过的巨大计算