Community Outreach and Education Core (Core B)

社区外展和教育核心（核心 B）

• 批准号: 10260437
• 负责人: CHRISTINA C. WANG
• 金额: $ 11.61万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-13 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260437
• 关键词: Academia; Affect; African; African American; Americas; Awareness; Biomedical Research; Body Weight decreased; California; Cardiovascular Diseases; Child; Clinical Sciences; Collaborations; Communication; Communities; Community Health; Community Outreach; Conflict of Interest; Daughter; Disease; Education and Outreach; Educational workshop; Environment; Epigenetic Process; Family; Future; Gene Expression; Gene Expression Regulation; Genomics; Glucose Intolerance; Goals; Health; Health Promotion; Health education; High School Student; Hispanic; Hypertension; Infrastructure; Institutes; Institution; Insulin Resistance; Kidney Diseases; Knowledge; Lead; Life Style; Link; Los Angeles; Medical; Medical center; Metabolic Diseases; Metabolic syndrome; Methods; Modification; Names; National Center for Advancing Translational Sciences; Native Hawaiian; Needs Assessment; Nevada; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pacific Islander; Parents; Phenotype; Procedures; Reproductive Health; Research; Research Institute; Research Personnel; Role; Stroke; Structure; Surveys; Texas; Translational Research; Trust; Unhealthy Diet; Universities; Weight; Youth; base; cardiovascular risk factor; college; community engagement; conflict resolution; design; disease phenotype; disease transmission; education research; egg; epigenetic regulation; epigenome; epigenomics; evidence base; experience; health disparity; healthy lifestyle; high school; high school program; intergenerational; male; next generation; novel; obesity management; offspring; operation; physical inactivity; programs; reproductive; sperm cell; summer program; symposium; university student; web site; working group; young adult; young man; young woman

The Community Outreach and Education Core of the Center for Male Reproductive Epigenomics will be located and operated though Los Angeles Biomedical Research Institute (LA Biomed) at Harbor-UCLA Medical Center located in South West Los Angeles. This Core will develop outreach and education programs designed to disseminate information on the effects of life styles on the epigenetic regulation of sperm gene expression that may be transmitted to the next generation. Our theme is to promote “Healthy life style, Healthy sperm epigenome, Healthy babies”. Building on our prior collaboration and community-academic partnership, we plan to achieve our goals by engaging youths, high school and college students, and younger adults from our communities to disseminate information on reproductive epigenomics and their effects on the next generation. We have four aims: Aim 1. Promote and sustain bidirectional knowledge sharing between the community and academic institutions by providing opportunities for networking and developing a community specific dissemination plan for evidence based information on how obesity and inactivity change the sperm epigenome transmitting unhealthy phenotype and epigenotype to the next generation. Aim 2. Create educational programs, workshops and conferences to engage younger adults, college and high school students (future parents) to disseminate information on “healthy life styles, healthy reproductive epigenome; healthy babies”. With our partners we will conduct community-partnered research conferences and workshops for younger adults, and summer program for high school and college students to provide knowledge transfer on the impact of environment on epigenetics? how improvement in the environment may reverse maladaptive epigenetic changes? and how epigenetics are linked to intergenerational transmission of disease phenotype? Aim 3. Develop a community focused website for the Center for Male Reproductive Genomics. Working with our community partners, academic partners at the University of Nevada Reno and the University of Texas San Antonio, we will develop a culturally and racially sensitive website to provide information on the role of epigenomics in reproductive health in general and impact of sperm epigenomics on next generation’s health. Aim 4. Establish the governance and operation structure of the Community Core Advisory Council that strengthens existing partnerships and builds new bridges between community and academia for education and research.

男性生殖表观基因组学中心的社区外展和教育核心将位于 并通过哈伯-加州大学洛杉矶分校医学中心的洛杉矶生物医学研究所（LA Biomed）进行操作 位于洛杉矶西南部。该核心将制定外联和教育方案， 传播关于生活方式对精子基因表达的表观遗传调节的影响的信息， 可以传给下一代。我们的主题是提倡“健康生活方式，健康精子 表观基因组，健康的婴儿”。基于我们先前的合作和社区-学术伙伴关系，我们计划 通过吸引青年、高中生和大学生以及来自我们国家的年轻人来实现我们的目标。 社区传播关于生殖表观基因组学及其对下一代的影响的信息。 我们有四个目标：目标1。促进和维持社区之间的双向知识共享， 学术机构，提供机会，建立网络和发展一个社区具体 关于肥胖和不活动如何改变精子表观基因组的循证信息传播计划 将不健康的表型和表观基因型传递给下一代。目标二。创建教育计划， 举办讲习班和会议，吸引年轻人、大学生和高中生（未来的父母）， 传播关于“健康生活方式、健康生殖表观基因组、健康婴儿”的信息。与我们 我们将为年轻人举办社区合作研究会议和研讨会， 暑期课程对高中生和大学生提供知识转移的影响 环境对表观遗传学的影响环境的改善如何逆转适应不良的表观遗传 变化？以及表观遗传学与疾病表型的代际传递有何联系？目标3. 为男性生殖基因组学中心开发一个以社区为中心的网站。与我们的 社区合作伙伴、内华达州里诺大学和德克萨斯大学圣 安东尼奥，我们将开发一个文化和种族敏感的网站，提供有关的作用， 生殖健康中的表观基因组学以及精子表观基因组学对下一代健康的影响。 目标4。建立社区核心咨询理事会的治理和运作结构， 加强现有的伙伴关系，在社区和学术界之间建立新的教育桥梁， research.