Community Outreach and Education Core (Core B)

社区外展和教育核心（核心 B）

• 批准号: 10018081
• 负责人: CHRISTINA C. WANG
• 金额: $ 11.59万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-13 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10018081
• 关键词: Academia; Affect; African; African American; Americas; Awareness; Biomedical Research; Body Weight decreased; California; Cardiovascular Diseases; Child; Clinical Sciences; Collaborations; Communication; Communities; Community Health; Community Outreach; Conflict of Interest; Daughter; Disease; Education and Outreach; Educational workshop; Environment; Epigenetic Process; Family; Future; Gene Expression; Gene Expression Regulation; Genomics; Glucose Intolerance; Goals; Health; Health Promotion; Health education; High School Student; Hispanics; Hypertension; Infrastructure; Institutes; Institution; Insulin Resistance; Kidney Diseases; Knowledge; Lead; Life Style; Link; Los Angeles; Medical; Medical center; Metabolic Diseases; Metabolic syndrome; Methods; Modification; Names; Native Hawaiian; Needs Assessment; Nevada; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pacific Island Americans; Parents; Phenotype; Procedures; Reproductive Health; Research; Research Institute; Research Personnel; Role; Stroke; Structure; Surveys; Texas; Translational Research; Trust; Unhealthy Diet; Universities; Weight; Youth; base; cardiovascular risk factor; college; conflict resolution; design; disease phenotype; disease transmission; education research; egg; epigenetic regulation; epigenome; epigenomics; evidence base; experience; health disparity; healthy lifestyle; high school; high school program; intergenerational; male; next generation; novel; obesity management; offspring; operation; physical inactivity; programs; reproductive; sperm cell; summer program; symposium; university student; web site; working group; young adult; young man; young woman

The Community Outreach and Education Core of the Center for Male Reproductive Epigenomics will be located and operated though Los Angeles Biomedical Research Institute (LA Biomed) at Harbor-UCLA Medical Center located in South West Los Angeles. This Core will develop outreach and education programs designed to disseminate information on the effects of life styles on the epigenetic regulation of sperm gene expression that may be transmitted to the next generation. Our theme is to promote “Healthy life style, Healthy sperm epigenome, Healthy babies”. Building on our prior collaboration and community-academic partnership, we plan to achieve our goals by engaging youths, high school and college students, and younger adults from our communities to disseminate information on reproductive epigenomics and their effects on the next generation. We have four aims: Aim 1. Promote and sustain bidirectional knowledge sharing between the community and academic institutions by providing opportunities for networking and developing a community specific dissemination plan for evidence based information on how obesity and inactivity change the sperm epigenome transmitting unhealthy phenotype and epigenotype to the next generation. Aim 2. Create educational programs, workshops and conferences to engage younger adults, college and high school students (future parents) to disseminate information on “healthy life styles, healthy reproductive epigenome; healthy babies”. With our partners we will conduct community-partnered research conferences and workshops for younger adults, and summer program for high school and college students to provide knowledge transfer on the impact of environment on epigenetics? how improvement in the environment may reverse maladaptive epigenetic changes? and how epigenetics are linked to intergenerational transmission of disease phenotype? Aim 3. Develop a community focused website for the Center for Male Reproductive Genomics. Working with our community partners, academic partners at the University of Nevada Reno and the University of Texas San Antonio, we will develop a culturally and racially sensitive website to provide information on the role of epigenomics in reproductive health in general and impact of sperm epigenomics on next generation’s health. Aim 4. Establish the governance and operation structure of the Community Core Advisory Council that strengthens existing partnerships and builds new bridges between community and academia for education and research.

男性生殖表观基因组学中心的社区外展和教育核心将设在 并通过位于港口-加州大学洛杉矶分校医疗中心的洛杉矶生物医学研究所 (LA Biomed) 运营 位于洛杉矶西南部。该核心将制定外展和教育计划，旨在 传播有关生活方式对精子基因表达表观遗传调控影响的信息 可能会遗传给下一代。我们的主题是提倡“健康生活方式，健康精子” 表观基因组，健康婴儿”。在我们之前的合作和社区学术伙伴关系的基础上，我们计划 通过让青少年、高中生、大学生以及来自我们的年轻人参与来实现我们的目标 社区传播有关生殖表观基因组学及其对下一代影响的信息。 我们有四个目标： 目标 1. 促进和维持社区和社区之间的双向知识共享 学术机构通过提供网络机会和发展社区特定的 关于肥胖和缺乏活动如何改变精子表观基因组的循证信息传播计划 将不健康的表型和表观基因型传递给下一代。目标 2. 创建教育计划， 举办研讨会和会议，让年轻人、大学生和高中生（未来的父母）参与 传播“健康生活方式、健康生殖表观基因组、健康婴儿”的信息。与我们的 合作伙伴，我们将为年轻人举办社区合作研究会议和研讨会，以及 为高中生和大学生提供关于影响的知识转移的暑期计划 环境对表观遗传学的影响？环境的改善如何扭转表观遗传适应不良 变化？表观遗传学如何与疾病表型的代际传播相关？目标3。 为男性生殖基因组学中心开发一个以社区为中心的网站。与我们合作 社区合作伙伴、内华达大学里诺分校和德克萨斯大学圣分校的学术合作伙伴 安东尼奥，我们将开发一个对文化和种族敏感的网站，以提供有关以下角色的信息： 一般生殖健康中的表观基因组学以及精子表观基因组学对下一代健康的影响。 目标 4. 建立社区核心咨询委员会的治理和运营结构， 加强现有的伙伴关系，并在社区和学术界之间建立新的桥梁，以促进教育和 研究。