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Center for Caenorhabditis Elegans Anatomy

秀丽隐杆线虫解剖中心

基本信息

批准号：
10218285
负责人：
DAVID H. HALL
金额：
$ 68.64万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-01 至 2022-12-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218285
关键词：
Adopted Adult Affect Agriculture Anatomy Animal Model Animals Apoptosis Archives Atlases Autophagocytosis Behavior Biology Books Brain C. elegans genome Caenorhabditis elegans Cell Death Cellular biology Collaborations Communities DNA Sequence Alteration Data Databases Denervation Development Disease Drops Electrons Event Funding Genes Genetic Genome Goals Grant Health Histocytochemistry Human Image Kidney Kinesin Knowledge Laboratories Ligands Light Maintenance Methods Microscopic Microtomy Mission Modernization Motor Muscle Necrosis Nematoda Neurotransmitter Receptor Pathology Postdoctoral Fellow Publishing Research Research Project Grants Structural Models Students Surveys Synaptic Vesicles System Techniques Technology Testing Text Training United States National Institutes of Health Vertebrates axon guidance base cellular development experimental study gene product man method development netrin receptor parasitism public health relevance receptor expression synergism training opportunity vesicle transport web site

项目摘要

ABSTRACT The nematode, Caenorhabditis elegans, has been identified as a “high connectivity” animal for cellular development. This very small simple animal has been widely adopted for experimental study due to its excellent genetics and accessible cell biology. The complete genome of the worm has been published, and most of the adult anatomy has been reconstructed from electron micrographs of serial thin sections. However, EM techniques are not widely utilized by the C. elegans community, and most previous EM data are not easily accessed except through the support of this grant. The Center for C. elegans Anatomy concentrates on 1) publishing detailed information regarding the anatomy of the nematode in the form of annotated TEM and light micrographs, available on our two websites WormAtlas (text-based) and WormImage (image database), and by ftp, on hard drives, and in book form as the C. elegans Atlas. The Center is 2) providing practical training in modern EM methods for students and postdoc's and 3) testing new EM methods for C. elegans. We also conduct new EM surveys of the wild type anatomy at key developmental stages to supplement the Atlas, and to fill in gaps in our general knowledge.

摘要线虫，线虫秀丽线虫，已被确定为“高细胞发育的“连通性”动物。这种非常小的简单的动物有由于其优良的遗传学和生物学特性，被广泛应用于实验研究可接近的细胞生物学。这种蠕虫的完整基因组已经公布，大部分成人解剖结构都是从电子设备上重建的连续薄片的显微照片。然而，EM技术并不广泛被线虫社区利用，而大多数以前的EM数据并不容易除非通过这笔赠款的支持，否则可以进入。秀丽线虫中心《解剖学》专注于1)出版关于用带注释的电子显微镜和光学显微照片的形式对线虫进行解剖，在我们的两个网站WormAtlas(基于文本)和WormImage(图像)上提供数据库)，并通过ftp、硬盘驱动器和书本形式作为《线虫地图集》。该中心为学生提供现代电磁方法的实践培训和博士后以及3)测试线虫的新EM方法。我们还进行野生型解剖在关键发育阶段的新EM调查补充地图集，填补我们常识的空白。