权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Translational Research Workforce Training: Leveraging the Veterinary Specialist

转化研究人员培训：利用兽医专家

基本信息

批准号：
10221789
负责人：
LAUREN A TREPANIER
金额：
$ 58.65万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10221789
关键词：
Address Animal Disease Models Animal Diseases Animal Model Animals Award Biomedical Research Canis familiaris Cardiomyopathies Chronic Disease Clinical Collaborations Communication Companions Complement Complex Genetic Trait Controlled Study Degenerative polyarthritis Development Disease Disease Progression Doctor of Philosophy Domestic Animals Educational workshop Engineering Environmental Exposure Epilepsy Faculty Family suidae Felis catus Fellowship Funding Genetic Engineering Glaucoma Goals Grant Health Health Professional Hemophilia A Heterogeneity Human Immersion Inbreeding Infrastructure Interdisciplinary Study Knowledge Laboratories Life Medical Mentors Mentorship Modeling Nursing Faculty Pathogenesis Patients Physicians Positioning Attribute Reporting Research Research Personnel Research Training Residencies Rodent Rodent Model Sampling Science Scientist Specialist Teaching Hospitals Testing Thinness Training Translating Translational Research United States National Institutes of Health Veterinarians Walking Writing biomedical scientist career companion animal comparative cost disease phenotype early-career faculty evidence base experience flexibility gene interaction genomic locus human disease interest medical specialties member preclinical trial programs recruit response role model symposium translational medicine working group

项目摘要

! Project summary Advances in human health rely on valid animal models of disease. Inbred or genetically engineered rodent models can answer important questions about disease pathogenesis and test promising therapies, but can sometimes fail to predict disease responses seen in humans. Spontaneously occurring diseases in companion and other domestic animals can complement the use of engineered laboratory models to understand human diseases, especially those that involve complex genetic traits, disease-modifying gene loci, environmental-gene interactions, or chronic disease progression. Veterinary clinician-scientists have expertise in these naturally occurring animal diseases, and have much to contribute to interdisciplinary research teams that are working to solve human health problems. The purpose of this proposal is to support the development of veterinary specialists into clinician-scientists capable of being productive contributors to translational research. This proposal outlines 3 initiatives: 1) targeted post-residency Translational Research Fellowships for veterinary specialists, to perform research with inter-disciplinary teams on spontaneous diseases shared by humans and animals; 2) a Translational Research Immersion Program for early career clinical faculty, to provide key training in grant writing and mentorship, and showcase successful models of interdisciplinary research collaborations; and 3) convene Translational Research Summits for established veterinary and human medical researchers working on the same diseases, to accelerate the use of spontaneous animal models to understand human disease. The long-term goals of this Translational Research Workforce Training proposal are to catalyze interdisciplinary translational research among veterinarians, basic scientists, physicians and other human health professionals. These three initiatives will provide a generalizable model to recruit clinical specialists of all backgrounds to centers of excellence within the CTSA network, provide immersion research training for clinical faculty followed by evidence-based mentoring support, and bring together clinicians and scientists from different walks of life to collaborate around shared disease interests.

！项目概要人类健康的进步依赖于有效的疾病动物模型。近交或基因工程啮齿动物模型可以回答有关疾病发病机制的重要问题并测试有前途的疗法，但可以有时无法预测人类的疾病反应。伴侣动物和其他家畜自发发生的疾病可以补充使用设计实验室模型来了解人类疾病，特别是那些涉及复杂遗传的疾病性状、疾病修饰基因位点、环境基因相互作用或慢性疾病进展。兽医临床科学家在这些自然发生的动物疾病方面拥有丰富的专业知识，并且有很多值得研究的地方。为致力于解决人类健康问题的跨学科研究团队做出贡献。该提案的目的是支持兽医专家发展为临床科学家能够为转化研究做出富有成效的贡献。该提案概述了 3 项举措：1) 为兽医专家提供有针对性的驻院后转化研究奖学金，与人类和动物共有的自发性疾病跨学科团队； 2）转化研究为早期职业临床教师提供沉浸式计划，提供资助写作和指导方面的关键培训，以及展示跨学科研究合作的成功模式； 3) 召开翻译会议为研究相同疾病的兽医和人类医学研究人员举办研究峰会，加速利用自发动物模型来了解人类疾病。该转化研究劳动力培训提案的长期目标是促进兽医、基础科学家、医生和其他人员之间的跨学科转化研究人类健康专业人员。这三项举措将为招募临床人员提供一个通用模型 CTSA 网络内的卓越中心拥有各种背景的专家，提供沉浸式研究对临床教师进行培训，然后提供基于证据的指导支持，并将临床医生和来自各行各业的科学家围绕共同的疾病兴趣开展合作。