Translational Research Workforce Training: Leveraging the Veterinary Specialist

转化研究人员培训：利用兽医专家

• 批准号: 10475602
• 负责人: LAUREN A TREPANIER
• 金额: $ 33.91万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475602
• 关键词: Address; Animal Disease Models; Animal Diseases; Animal Model; Animals; Award; Biomedical Research; Canis familiaris; Cardiomyopathies; Chronic Disease; Clinical; Collaborations; Communication; Companions; Complement; Complex Genetic Trait; Controlled Study; Degenerative polyarthritis; Development; Disease; Disease Progression; Doctor of Philosophy; Domestic Animals; Educational workshop; Engineering; Environmental Exposure; Epilepsy; Faculty; Family suidae; Felis catus; Fellowship; Funding; Genetic Engineering; Glaucoma; Grant; Health; Health Professional; Hemophilia A; Heterogeneity; Human; Immersion; Inbreeding; Infrastructure; Interdisciplinary Study; Knowledge; Laboratories; Life; Medical; Mentors; Mentorship; Modeling; National Center for Advancing Translational Sciences; Nursing Faculty; Pathogenesis; Patients; Physicians; Positioning Attribute; Reporting; Research; Research Personnel; Research Training; Residencies; Rodent; Rodent Model; Sampling; Science; Scientist; Specialist; Teaching Hospitals; Testing; Thinness; Training; Translating; Translational Research; United States National Institutes of Health; Veterinarians; Walking; Writing; biomedical scientist; career; companion animal; comparative; cost; disease phenotype; early-career faculty; evidence base; experience; flexibility; gene interaction; genomic locus; human disease; interest; medical specialties; member; preclinical trial; programs; recruit; response; role model; symposium; translational goal; translational medicine; working group

! Project summary Advances in human health rely on valid animal models of disease. Inbred or genetically engineered rodent models can answer important questions about disease pathogenesis and test promising therapies, but can sometimes fail to predict disease responses seen in humans. Spontaneously occurring diseases in companion and other domestic animals can complement the use of engineered laboratory models to understand human diseases, especially those that involve complex genetic traits, disease-modifying gene loci, environmental-gene interactions, or chronic disease progression. Veterinary clinician-scientists have expertise in these naturally occurring animal diseases, and have much to contribute to interdisciplinary research teams that are working to solve human health problems. The purpose of this proposal is to support the development of veterinary specialists into clinician-scientists capable of being productive contributors to translational research. This proposal outlines 3 initiatives: 1) targeted post-residency Translational Research Fellowships for veterinary specialists, to perform research with inter-disciplinary teams on spontaneous diseases shared by humans and animals; 2) a Translational Research Immersion Program for early career clinical faculty, to provide key training in grant writing and mentorship, and showcase successful models of interdisciplinary research collaborations; and 3) convene Translational Research Summits for established veterinary and human medical researchers working on the same diseases, to accelerate the use of spontaneous animal models to understand human disease. The long-term goals of this Translational Research Workforce Training proposal are to catalyze interdisciplinary translational research among veterinarians, basic scientists, physicians and other human health professionals. These three initiatives will provide a generalizable model to recruit clinical specialists of all backgrounds to centers of excellence within the CTSA network, provide immersion research training for clinical faculty followed by evidence-based mentoring support, and bring together clinicians and scientists from different walks of life to collaborate around shared disease interests.

! 项目摘要 人类健康的进步依赖于有效的疾病动物模型。近交或基因工程啮齿动物 模型可以回答有关疾病发病机制的重要问题，并测试有希望的治疗方法， 有时无法预测人类的疾病反应。 伴侣动物和其他家畜中自发发生的疾病可以补充使用 工程实验室模型，以了解人类疾病，特别是那些涉及复杂的遗传 性状、疾病修饰基因位点、环境-基因相互作用或慢性疾病进展。 兽医临床医生-科学家在这些自然发生的动物疾病方面具有专业知识， 为致力于解决人类健康问题的跨学科研究团队做出贡献。 该提案的目的是支持兽医专家发展成为临床科学家 能够成为转化研究的富有成效的贡献者。该提案概述了3项举措：1） 为兽医专家提供有针对性的驻院后转化研究奖学金， 人类和动物自发性疾病的跨学科团队; 2）转化研究 为早期职业临床教师提供沉浸式课程，以提供赠款写作和指导方面的关键培训， 展示跨学科研究合作的成功模式; 3）召开翻译会议 为从事相同疾病研究的知名兽医和人类医学研究人员举办研究峰会， 加速使用自发的动物模型来了解人类疾病。 这项转化研究劳动力培训提案的长期目标是促进 兽医，基础科学家，医生和其他跨学科的翻译研究 人类健康专业人员。这三项举措将提供一个可推广的模式，以招募临床 所有背景的专家到CTSA网络内的卓越中心，提供沉浸式研究 培训临床教师，然后提供循证指导支持，并将临床医生和 来自各行各业的科学家围绕共同的疾病利益进行合作。

项目成果

Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model.

• DOI: 10.3389/fvets.2021.697551
• 发表时间: 2021
• 期刊: Frontiers in veterinary science
• 影响因子: 3.2
• 作者: Gaesser AM;Underwood C;Linardi RL;Even KM;Reef VB;Shetye SS;Mauck RL;King WJ;Engiles JB;Ortved KF
• 通讯作者: Ortved KF

An Aptamer-Based Proteomic Analysis of Plasma from Cats (Felis catus) with Clinical Feline Infectious Peritonitis.

• DOI: 10.3390/v16010141
• 发表时间: 2024-01-18
• 期刊: Viruses
• 作者: Curtis BE;Abdo Z;Graham B;LaVoy A;Evans SJM;Santangelo K;Dean GA
• 通讯作者: Dean GA

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion.

• DOI: 10.1097/txd.0000000000001390
• 发表时间: 2022-11
• 期刊: Transplantation direct
• 影响因子: 2.3

Naturally occurring canine sarcomas: Bridging the gap from mouse models to human patients through cross-disciplinary research partnerships.

• DOI: 10.3389/fonc.2023.1130215
• 发表时间: 2023
• 期刊: Frontiers in oncology
• 影响因子: 4.7

Age- and sex-associated differences in hematology and biochemistry parameters of Dunkin Hartley guinea pigs (Cavia porcellus).

• DOI: 10.1371/journal.pone.0253794
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Spittler AP;Afzali MF;Bork SB;Burton LH;Radakovich LB;Seebart CA;Moore AR;Santangelo KS
• 通讯作者: Santangelo KS