Washington University Intellectual and Developmental Disabilities Research Center
华盛顿大学智力与发育障碍研究中心
基本信息
- 批准号:10224301
- 负责人:
- 金额:$ 126万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-28 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAnimal ModelBehaviorBehavioralBiocompatible MaterialsBioinformaticsBiological MarkersBiological ModelsBrainBrain imagingCaliberCell LineCell modelCellsChildClinicalClinical TrialsCollectionCommunitiesCore FacilityDataData SetDerivation procedureDevelopmentDevelopmental DisabilitiesDiseaseDown SyndromeElectronic Health RecordEnrollmentEquipment and supply inventoriesEtiologyExtramural ActivitiesFacultyFamilial diseaseFamilyFunctional disorderFundingGene DosageGenerationsGenesGeneticGenomicsGoalsHumanImageIndividualInfantInfrastructureInstitutesInstitutionIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInterruptionInterventionInvestigationKnowledgeLongitudinal StudiesMethodsMolecularMothersMutationNatural HistoryNeurodevelopmental DisabilityNeurosciencesPathogenesisPathway interactionsPatientsPhasePhenotypePopulationPreventionQuality of lifeRegistriesResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRiskRodent ModelScienceScientistSpecialized CenterStandardizationStructureSynapsesSyndromeTherapeuticTo specifyTranslatingTranslational ResearchTranslationsUnited States National Institutes of HealthUniversitiesVariantWashingtonautism spectrum disorderbasebehavioral genomicsbehavioral phenotypingcognitive neurosciencecohortfollow-upfrontierfunctional genomicsgene discoverygenetic variantimaging studymedical schoolsmultiple omicsneuroimagingnew therapeutic targetnovelnovel therapeuticspatient populationprematurepreventpreventive interventionprogramsprospectivepsychosocialrelating to nervous systemsuccesssynergismworking group
项目摘要
Overall Project Abstract
For the third cycle of the Intellectual and Developmental Disabilities Research Center at Washington University,
we propose a next phase in a comprehensive approach to understanding, ameliorating, and/or preventing
neurodevelopmental disability through translational scientific investigation at the respective levels of cell,
synapse, circuit, and behavior, capitalizing upon major strengths of WUSTL in genomics, behavioral/cognitive
neuroscience, and clinical-translational science. The overarching goals of our Center are as follows: (1) To
sustain and evolve an integrated structure of core scientific facilities that occupy a critical niche in the scientific
community, attract and support highly-qualified investigators, and facilitate high-caliber, translational research
on the pathogenesis and treatment of IDDs. In this application we propose specific enhancements to each of our
scientific core facilities: an expanded technical team for the Developmental Neuroimaging Core, a dedicated
cellular models unit within the Model Systems Core (methods calibrated with a cross-IDDRC working group for
cellular models of IDD co-led by the IDDRC@WUSTL), and a new clinical trials / natural history studies unit
within the Clinical-Translational Core (CTC). The CTC will continue to facilitate the collection and interpretation
of genomic, phenotypic, environmental and biomarker data across generations, and promote step-wise
translation of new discoveries on risk and pathogenesis to higher-impact interventions for patients. The
IDDRC@WUSTL will provide critical infrastructure for research efforts that have created synergies with other
intramural and extramural Centers/Institutes, including a newly-funded in-depth longitudinal study of infants born
to mothers enrolled in the March of Dimes Prematurity Research Center Cohort, the launch of a prospective
replication cohort for the Infant Brain Imaging Study of Autism (IBIS), two multisite initiatives in Down Syndrome,
and an NIH Autism Center of Excellence Network in gene discovery. (2) To cultivate nodes of new
interdisciplinary scientific activity within the Center, in frontiers of IDD research which are critical for the derivation
of higher-impact treatment and preventive intervention, along the Center’s four major themes: (i) the prevention
of prematurity and its neurodevelopmental consequences; (ii) the identification of intermediate phenotypes in the
development of IDD; (iii) structural and functional characterization of the developing human brain, and (iv)
functional genomics relevant to IDD pathogenesis. In this cycle we will build on prior successes in cultivating a
dynamic, interactive, and productive community of scientists engaged in IDD-science, challenging itself to
generate and harness new knowledge toward translational advances in therapeutics and prevention. (3) To
conduct a signature research project that represents a bold, critical step toward higher-impact intervention for
IDD. In this project, a novel platform for standardizing multi-omic characterization of the consequences of
variation in gene dosage will be implemented across dozens of isogenic cell lines, each representing
haploinsufficiency in a different high-confidence IDD-related gene, to identify convergent mechanisms of IDD.
总体项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN N. CONSTANTINO其他文献
JOHN N. CONSTANTINO的其他文献
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{{ truncateString('JOHN N. CONSTANTINO', 18)}}的其他基金
Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
- 批准号:
10408656 - 财政年份:2021
- 资助金额:
$ 126万 - 项目类别:
Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
- 批准号:
10300870 - 财政年份:2021
- 资助金额:
$ 126万 - 项目类别:
Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
- 批准号:
10631976 - 财政年份:2021
- 资助金额:
$ 126万 - 项目类别:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
利用临床基因组特征加速 IDD 患者的转化进展
- 批准号:
9976668 - 财政年份:2020
- 资助金额:
$ 126万 - 项目类别:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
利用临床基因组特征加速 IDD 患者的转化进展
- 批准号:
10159337 - 财政年份:2020
- 资助金额:
$ 126万 - 项目类别:
Washington University Intellectual and Developmental Disabilities Research Center
华盛顿大学智力与发育障碍研究中心
- 批准号:
10085124 - 财政年份:2020
- 资助金额:
$ 126万 - 项目类别:
Identification of Newborns at High Risk for the Occurrence of Preventable Child Maltreatment
识别发生可预防的儿童虐待的高风险新生儿
- 批准号:
10475106 - 财政年份:2018
- 资助金额:
$ 126万 - 项目类别:
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