Washington University Intellectual and Developmental Disabilities Research Center

华盛顿大学智力与发育障碍研究中心

基本信息

  • 批准号:
    10224301
  • 负责人:
  • 金额:
    $ 126万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-28 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Overall Project Abstract For the third cycle of the Intellectual and Developmental Disabilities Research Center at Washington University, we propose a next phase in a comprehensive approach to understanding, ameliorating, and/or preventing neurodevelopmental disability through translational scientific investigation at the respective levels of cell, synapse, circuit, and behavior, capitalizing upon major strengths of WUSTL in genomics, behavioral/cognitive neuroscience, and clinical-translational science. The overarching goals of our Center are as follows: (1) To sustain and evolve an integrated structure of core scientific facilities that occupy a critical niche in the scientific community, attract and support highly-qualified investigators, and facilitate high-caliber, translational research on the pathogenesis and treatment of IDDs. In this application we propose specific enhancements to each of our scientific core facilities: an expanded technical team for the Developmental Neuroimaging Core, a dedicated cellular models unit within the Model Systems Core (methods calibrated with a cross-IDDRC working group for cellular models of IDD co-led by the IDDRC@WUSTL), and a new clinical trials / natural history studies unit within the Clinical-Translational Core (CTC). The CTC will continue to facilitate the collection and interpretation of genomic, phenotypic, environmental and biomarker data across generations, and promote step-wise translation of new discoveries on risk and pathogenesis to higher-impact interventions for patients. The IDDRC@WUSTL will provide critical infrastructure for research efforts that have created synergies with other intramural and extramural Centers/Institutes, including a newly-funded in-depth longitudinal study of infants born to mothers enrolled in the March of Dimes Prematurity Research Center Cohort, the launch of a prospective replication cohort for the Infant Brain Imaging Study of Autism (IBIS), two multisite initiatives in Down Syndrome, and an NIH Autism Center of Excellence Network in gene discovery. (2) To cultivate nodes of new interdisciplinary scientific activity within the Center, in frontiers of IDD research which are critical for the derivation of higher-impact treatment and preventive intervention, along the Center’s four major themes: (i) the prevention of prematurity and its neurodevelopmental consequences; (ii) the identification of intermediate phenotypes in the development of IDD; (iii) structural and functional characterization of the developing human brain, and (iv) functional genomics relevant to IDD pathogenesis. In this cycle we will build on prior successes in cultivating a dynamic, interactive, and productive community of scientists engaged in IDD-science, challenging itself to generate and harness new knowledge toward translational advances in therapeutics and prevention. (3) To conduct a signature research project that represents a bold, critical step toward higher-impact intervention for IDD. In this project, a novel platform for standardizing multi-omic characterization of the consequences of variation in gene dosage will be implemented across dozens of isogenic cell lines, each representing haploinsufficiency in a different high-confidence IDD-related gene, to identify convergent mechanisms of IDD.
总体项目摘要

项目成果

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JOHN N. CONSTANTINO其他文献

JOHN N. CONSTANTINO的其他文献

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{{ truncateString('JOHN N. CONSTANTINO', 18)}}的其他基金

Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
  • 批准号:
    10408656
  • 财政年份:
    2021
  • 资助金额:
    $ 126万
  • 项目类别:
Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
  • 批准号:
    10300870
  • 财政年份:
    2021
  • 资助金额:
    $ 126万
  • 项目类别:
Missouri Study to Explore Early Development (SEED) Follow-Up
密苏里州研究探索早期发育 (SEED) 后续行动
  • 批准号:
    10631976
  • 财政年份:
    2021
  • 资助金额:
    $ 126万
  • 项目类别:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
利用临床基因组特征加速 IDD 患者的转化进展
  • 批准号:
    9976668
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Harnessing Clinical Genomic Characterization to Accelerate Translational Advances for Patients with IDD
利用临床基因组特征加速 IDD 患者的转化进展
  • 批准号:
    10159337
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10224302
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10631990
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Washington University Intellectual and Developmental Disabilities Research Center
华盛顿大学智力与发育障碍研究中心
  • 批准号:
    10085124
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10431919
  • 财政年份:
    2020
  • 资助金额:
    $ 126万
  • 项目类别:
Identification of Newborns at High Risk for the Occurrence of Preventable Child Maltreatment
识别发生可预防的儿童虐待的高风险新生儿
  • 批准号:
    10475106
  • 财政年份:
    2018
  • 资助金额:
    $ 126万
  • 项目类别:

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自闭症谱系障碍遗传学和社会行为的动物模型
  • 批准号:
    9340878
  • 财政年份:
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自闭症谱系障碍遗传学和社会行为的动物模型
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自闭症谱系障碍遗传学和社会行为的动物模型
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自闭症谱系障碍遗传学和社会行为的动物模型
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外源性神经肽 Y 对海洛因自我给药的影响:研究饮食行为与吸毒之间关系的动物模型。
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    378014-2009
  • 财政年份:
    2009
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长期点燃作为动物模型研究恐惧介导行为的神经机制
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    223012-1999
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  • 项目类别:
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