Administrative Core

行政核心项目摘要 在这个应用程序中，我们提出了一个核心的科学结构，是专门设计来支持科学工作 沿着早产预防和推进个性化医疗方法的总体主题， IDD;对于后者，利用中间表型阐明方面的专业知识，推进表征 以及功能基因组研究的基础设施。行政核心 承担科学监督的责任，作为一个综合中心，这是一个发现的转化管道 缺碘症研究的进展。具体目标是：1）维持一个有效的日常管理系统- 中心资金和资源的日常运作，包括必要资源的有效流动 维持三个高效，具有成本效益，最先进的核心科学设施，构成一个关键的 在WUSTL环境中IDD研究的基础设施：模型系统核心（MSC），开发 神经影像学核心（DNC）和临床转化核心（CTC）; 2）刺激壁内和壁外 沿着缺碘症研究的关键前沿开展科学合作和发现; 3）传播新知识 并通过与 发展障碍卓越大学中心（UCEDDs），领导力教育， 神经发育障碍（LEND），密苏里州部门。心理健康，区域临床提供者，以及 参与照料发育残疾儿童和成人的其他外部实体。

Administrative Core Project Abstract In this application we present a core scientific structure that is specifically designed to support scientific effort along the overarching themes of prematurity prevention and advancing personalized medicine approaches to IDD; for the latter, utilizing expertise in the elucidation of intermediate phenotypes, advancing characterization of the developing human brain, and infrastructures for functional genomic studies. The Administrative Core assumes responsibility for scientific oversight as an integrated Center that is a discovery pipeline for translational advances in IDD research. The Specific Aims are: 1) To sustain an effective system of management of the day- to-day operation of the Center’s funds and resources, which includes the efficient flow of necessary resources to maintain three efficient, cost-effective, state-of-the-art core scientific facilities that constitute a critical infrastructure for IDD research in the WUSTL environment: the Model Systems Core (MSC), the Developmental Neuroimaging Core (DNC), and the Clinical-Translational Core (CTC); 2) To stimulate intramural and extramural scientific collaboration and discovery along key frontiers of IDD research and 3) To disseminate new knowledge and implement practice improvements that are based upon new discovery, through partnerships with the University Centers of Excellence in Developmental Disabilities (UCEDDs), Leadership Education in Neurodevelopmental Disabilities (LENDs), the Missouri Dept. of Mental Health, regional clinical providers, and other external entities involved in the care of children and adults with developmental disabilities.