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Administrative Core

行政核心

基本信息

批准号：
10224302
负责人：
JOHN N. CONSTANTINO
金额：
$ 14.72万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224302
关键词：
Adult Area Attention Behavioral Biological Models Brain Child Care Clinical Collaborations Core Facility Development Developmental Disabilities Down Syndrome Education Ensure Environment Etiology Evolution Extramural Activities Faculty Funding Future Genetic Genome Head Human Individual Infrastructure Institutes Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interruption Investments Knowledge Laboratories Leadership Mental Health Microcephaly Mission Missouri Modeling National Institute of Child Health and Human Development Neurodevelopmental Disability Pathogenicity Pediatric Neurology Phase Phenotype Prevention Provider Psychiatry Research Research Personnel Research Training Resources Role Science Series Structure System Time Training Programs Translations United States National Institutes of Health Universities Washington Zika Virus base brain abnormalities cohesion cost effective design disability dual diagnosis frontier functional genomics improved member neuroimaging operation personalized medicine post-doctoral training premature prevent programs research facility standard of care translational pipeline

项目摘要

Administrative Core Project Abstract In this application we present a core scientific structure that is specifically designed to support scientific effort along the overarching themes of prematurity prevention and advancing personalized medicine approaches to IDD; for the latter, utilizing expertise in the elucidation of intermediate phenotypes, advancing characterization of the developing human brain, and infrastructures for functional genomic studies. The Administrative Core assumes responsibility for scientific oversight as an integrated Center that is a discovery pipeline for translational advances in IDD research. The Specific Aims are: 1) To sustain an effective system of management of the day- to-day operation of the Center’s funds and resources, which includes the efficient flow of necessary resources to maintain three efficient, cost-effective, state-of-the-art core scientific facilities that constitute a critical infrastructure for IDD research in the WUSTL environment: the Model Systems Core (MSC), the Developmental Neuroimaging Core (DNC), and the Clinical-Translational Core (CTC); 2) To stimulate intramural and extramural scientific collaboration and discovery along key frontiers of IDD research and 3) To disseminate new knowledge and implement practice improvements that are based upon new discovery, through partnerships with the University Centers of Excellence in Developmental Disabilities (UCEDDs), Leadership Education in Neurodevelopmental Disabilities (LENDs), the Missouri Dept. of Mental Health, regional clinical providers, and other external entities involved in the care of children and adults with developmental disabilities.

行政核心项目摘要在这个应用程序中，我们提出了一个核心的科学结构，是专门设计来支持科学工作沿着早产预防和推进个性化医疗方法的总体主题， IDD;对于后者，利用中间表型阐明方面的专业知识，推进表征以及功能基因组研究的基础设施。行政核心承担科学监督的责任，作为一个综合中心，这是一个发现的转化管道缺碘症研究的进展。具体目标是：1）维持一个有效的日常管理系统- 中心资金和资源的日常运作，包括必要资源的有效流动维持三个高效，具有成本效益，最先进的核心科学设施，构成一个关键的在WUSTL环境中IDD研究的基础设施：模型系统核心（MSC），开发神经影像学核心（DNC）和临床转化核心（CTC）; 2）刺激壁内和壁外沿着缺碘症研究的关键前沿开展科学合作和发现; 3）传播新知识并通过与发展障碍卓越大学中心（UCEDDs），领导力教育，神经发育障碍（LEND），密苏里州部门。心理健康，区域临床提供者，以及参与照料发育残疾儿童和成人的其他外部实体。