MIT/Harvard Center for Magnetic Resonance

麻省理工学院/哈佛大学磁共振中心

• 批准号: 10224248
• 负责人: ROBERT Guy GRIFFIN
• 金额: $ 104.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224248
• 关键词: 2,4-Dinitrophenol; 3-Dimensional; Agreement; Binding; Caliber; Cholesterol; Communities; Core Protein; Crystallization; Development; Diamond; Disease; Ensure; Equipment; Evolution; Frequencies; Funding; G-Protein-Coupled Receptors; Grant; Helium; Investigation; Isotope Labeling; Label; Laboratories; Libraries; Magic; Magnetic Resonance; Magnetic Resonance Spectroscopy; Measures; Membrane Proteins; Methods; Molecular; Morphologic artifacts; Motion; Nature; Nuclear; Nucleic Acids; Pharmacologic Substance; Physiologic pulse; Procedures; Production; Protein Dynamics; Proteins; Request for Proposals; Research; Resolution; Sampling; Schedule; Seeds; Side; Signal Transduction; Site; Structure; System; Techniques; Technology; Temperature; Tertiary Protein Structure; Thermal Conductivity; Time; Tyrosine; Vertebral column; base; biological systems; cohort; cost; cryogenics; design; dipole moment; experimental study; improved; instrument; instrumentation; magnetic dipole; magnetic field; microwave electromagnetic radiation; next generation; optimal control theory; protein function; protein structure; structural biology; theories; transmission process

Project Summary Overall The Overall section of the P41 presents a summary of the four TR&D projects which are part of the proposal. These include TR&D 1 – New instrumentation for magnetic resonance TR&D 2 – High-field and fast-MAS methods for biomolecular structure and dynamics TR&D 3 – Next generation solution NMR methods TR&D 4 -- Advanced Magic Angle Spinning NMR methods The specific aims of each of these projects is described and a summary of the contents in presented in more detail. In addition, we provide a rationale for the P41 center which includes the cost and size of present day instrumentation, the unique requirements for instruments and the sophistication of magnetic resonance spectroscopy. We also provide a table enumerating the equipment presently available for the CMR and a list of the new instrumentation that will be constructed during the five years of the proposed grant.

项目摘要 总括 P41的整体部分概述了四个研发项目，它们是 这是提案的一部分。这些措施包括 R&D 1-新的磁共振仪器 研发2-生物分子结构和动力学的高场和快速MAS方法 研发3-下一代溶液核磁共振方法 研发4--先进的魔角旋转核磁共振方法 每项计划的具体目标均有描述，内容摘要载于 更详细地介绍了。 此外，我们还提供了P41中心的基本原理，包括成本和规模 现代仪器，对仪器的独特要求，以及仪器的复杂性 磁共振光谱学。 我们还提供了一张表，列举了目前可用于CMR的设备和 将在拟议的五年内建造的新仪器的清单 格兰特。