Uncovering and Surveilling Financial Deception Risk in Aging - Alzheimer's Disease Supplement

拟议补编摘要，强调与AD/ADRD的相关性 决策能力下降和欺骗风险增加造成的经济损失构成 正在萌芽的公共卫生危机。一个数字互联的世界已经将金融欺诈转移到了网络领域。 健康的老年人和患有痴呆症(如阿尔茨海默病)的人在经济上可能面临特别大的风险 在线环境中的剥削，因为他们必须驾驭互联网决策的复杂性和模糊性 在处理与年龄相关的认知、社会情绪和神经生物学变化的同时 和疾病。然而，这些处于高剥削风险的个人在研究中被忽视了 网络攻击。缩小这一知识差距的一个战略，与母公司赠款的目标保持一致 确定金融欺诈风险侧写，是为了揭示风险较高的影响，加速认知 拒绝和阿尔茨海默氏症在线决策。从这个角度来看，在 父母资助，补充的目标是确定父母资助队列中的载脂蛋白E4(APOE4) 等位基因状态，这会增加患阿尔茨海默病的风险。该副刊将进一步扩大风险监控范围。 并将其纳入MindCrowd项目，该项目包括一个更大的成年寿命样本，之前进行了基因分型 对于APOE4状态，认知表型，对谁来说阿尔茨海默病的一级家族史是 为人所知。附录将(I)确定APOE4运营商是否更容易受到金融风险的影响 老龄化中的剥削(目标1)；(2)调查载脂蛋白4对认知/社会情感之间联系的影响 老龄化中的功能和金融利用风险(AIM 2)；和(3)确定APOE4地位在以下方面的作用 老龄化中脑结构、脑功能和金融利用风险之间的关系(目标3)。这些 新的AD/ADRD补充目标嵌入了我们的认知/社会情绪神经科学模型 老龄化中的财务决策和欺骗风险，并以父母赠款的初步数据为基础 支持老年人在我们的生态有效、基于行为的环境中对网络欺骗的高敏感性 现场实验(网络钓鱼任务；PHIT)与APOE4等位基因携带者的特殊风险易感性 在我们新开发的钓鱼电子邮件可疑测试(PEST)中；特别是在低APOE4运营商中 认知功能。这一补充将利用已建立的基础设施的父母资助，以基因 父母赠款队列N=280名处于APOE4状态的年轻人、中年人和老年人(研究1)；以及 通过管理我们的两个新的在线欺诈易感性范例(PHIT、 以及在MindCrowd队列中短期的社会情绪/财务决策(N=1,000； 20-95年；研究2)。本附录的结果将使我们能够扩展集成的、概念驱动的 病理性老龄化的金融利用风险描述方法，有可能为现实生活中的决策提供信息- 支持性干预措施，以降低健康老龄化和阿尔茨海默病的剥削风险。

Abstract of the proposed supplement highlighting the relevance to AD/ADRD Financial loss due to reduced decision-making capacity and increased risk of deception constitutes a burgeoning public health crisis. A digitally connected world has shifted financial fraud into the online realm. Healthy older adults and those with dementia (e.g., Alzheimer’s disease) may be at particular risk for financial exploitation in an online context, as they must navigate the complexities and ambiguity of internet decision making while also dealing with cognitive, socioemotional, and neurobiological changes associated with age and the disease. These individuals at heightened exploitation risk, however, are neglected in research on cyberattacks. One strategy for closing this knowledge gap, in alignment with the parent grant’s goal of determining financial deception risk profiling, is to uncover the impact of higher risk for accelerated cognitive decline and Alzheimer’s disease on online decision making. From this perspective, under the umbrella of the parent grant, the goal of the supplement is to determine in the parent grant cohort apolipoprotein E4 (APOE4) allele status, which increases risk for Alzheimer’s disease. The supplement will further extend risk surveillance and profiling into the MindCrowd project, which comprises a larger adult lifespan sample previously genotyped for APOE4 status, cognitively phenotyped, and for whom first-degree family history of Alzheimer’s disease is known. The supplement will (i) determine whether APOE4 carriers are at increased susceptibility to financial exploitation in aging (AIM 1); (ii) investigate APOE4 impact on the link between cognitive/socioemotional functions and financial exploitation risk in aging (AIM 2); and (iii) determine the role of APOE4 status on associations between brain structure, brain function, and financial exploitation risk in aging (AIM 3). These novel AD/ADRD supplement aims are embedded in our Cognitive/Socioemotional Neuroscience Model of Financial Decision-Making and Deception Risk in Aging and build on preliminary data from the parent grant supporting high susceptibility to online deception among older adults in our ecologically valid, behavior-based field experiment (PHishing Internet Task; PHIT) and particular risk susceptibility among APOE4 allele carriers in our newly developed Phishing Email Suspicion Test (PEST); especially among APOE4 carriers with low cognitive function. This supplement will leverage the established infrastructure of the parent grant to genotype the parent grant cohort of N=280 young, middle-aged, and older adults on APOE4 status (Study 1); and uniquely broaden data collection by administering our two new online fraud susceptibility paradigms (PHIT, PEST) as well as a short socioemotional/financial decision making battery in the MindCrowd cohort (N=1,000; 20-95 years; Study 2). Results from this supplement will allow extension of our integrated, conceptually driven approach to financial exploitation risk profiling into pathological aging, with potential to inform real-life decision- supportive interventions to reduce exploitation risks in healthy aging and Alzheimer’s disease.