Characterizing and modulating neurocognitive processes of learning to trust and distrust in aging

表征和调节衰老过程中学习信任和不信任的神经认知过程

• 批准号: 10622831
• 负责人: Natalie C Ebner
• 金额: $ 12.32万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622831
• 关键词: Adult; Age; Aging; Behavioral; Clinical; Cognitive; Computer Models; Cues; Data; Data Analyses; Decision Making; Disadvantaged; Elderly; Funding; Goals; Hispanic; Individual; Institution; Latina; Learning; Longevity; Mentors; Neurocognitive; Neurosciences; Population; Process; Psychological reinforcement; Research; Research Personnel; Sampling; Science; Site; Statistical Data Interpretation; Training; Trust; Woman; Work; Writing; career; career development; chronic pain; classical conditioning; clinical pain; disadvantaged background; distrust; neural circuit; neuroimaging; parent grant; research and development; skills; social; trustworthiness

Project Summary (Supplement). This supplement aims to bring Dr. Marilyn Horta, who is from an underrepresented background in the sciences at our institution and in the US, to work under the parent grant R01AG072658. This project offers an ideal context for Dr. Horta's research and career development given her goals of becoming an independent, productive researcher in aging and decision neuroscience. Dr. Horta would have the opportunity to (i) expertise in the identification and optimization of neurocognitive processes of learning to trust and distrust in particularly vulnerable and currently understudied older adult populations (i.e., individuals with chronic pain; disadvantaged groups); (ii) skills in advanced statistical analysis of behavioral and neuroimaging data; and (iii) enhanced presentation and academic writing abilities. Dr. Horta will work closely with her mentoring team that spans across the three parent grant sites and includes balanced expertise in in cognitive and socioemotional experimental aging and neuroimaging analysis (Dr. Ebner), computational modeling of reinforcement and learning (Dr. Wilson), decision neuroscience (Dr. Lighthall), and clinical pain and aging (Dr. Fillingim). On her initiative, Dr. Horta has successfully obtained pilot funding to investigate decision making among older adults with chronic pain, a particularly vulnerable and currently understudied older adult group regarding trust-related decision making. Integrating her clinical expertise in chronic pain populations under the parent grant, Dr. Horta will significantly contribute to all three parent grant aims. In particular, she will advance Aim 1, which is to confirm age deficits in learning to trust in an adult lifespan sample and determine the extent to which social cues of trustworthiness bias trust-related decisions and learning in older adults, by differentiating chronic pain status among the parent grant sample; and with her newly learned skills in computational modeling under the supplement will be able to isolate specific learning biases (e.g., social cue, loss aversion, and recency) under consideration of chronic pain status. Further, Dr. Horta's training in advanced neuroimaging data analysis will directly contribute to Aim 2, which seeks to confirm altered neurocircuitry underlying age-associated learning deficits; again, extending this work to chronic pain. Finally, findings from the analyses under Aims 1 and 2 will directly inform Aim 3 toward identifying the best target for training the malleability of the neurocircuitry underlying trust-learning deficits in vulnerable older adults.

项目摘要（补充）。本增刊的目的是把玛丽莲·奥尔塔博士，谁是从一个 在我们的机构和美国，在科学方面代表性不足的背景，在父母资助下工作 R01AG072658。这个项目为Horta博士的研究和职业发展提供了一个理想的背景， 目标是成为一个独立的，富有成效的研究人员在老化和决策神经科学。奥尔塔医生 有机会（i）识别和优化学习的神经认知过程的专业知识 信任和不信任特别脆弱和目前研究不足的老年人群体（即，个人 慢性疼痛;弱势群体）;（ii）行为和行为的高级统计分析技能， 神经成像数据;和（iii）增强的演示和学术写作能力。奥尔塔博士将与 与她的指导团队，跨越三个母公司赠款网站，并包括平衡的专业知识，在 认知和社会情绪实验老化和神经影像分析（Ebner博士），计算 强化和学习建模（威尔逊博士），决策神经科学（莱特霍尔博士），临床疼痛和 老化（Fillingim博士）。在她的倡议下，Horta博士成功地获得了试点资金， 在患有慢性疼痛的老年人中， 与信任相关的决策。将她在慢性疼痛人群中的临床专业知识 父母补助金，博士奥尔塔将大大有助于所有三个父母补助金的目标。特别是，她将提前 目的1，这是为了证实年龄缺陷，在学习信任的成年人寿命样本，并确定程度 值得信赖的社会线索偏见与信任有关的决策和学习在老年人中，通过区分 慢性疼痛状态的父母补助金样本;并与她新学到的技能，在计算建模 在补充下将能够隔离特定的学习偏差（例如，社会线索、损失厌恶和近因） 考虑到慢性疼痛状态。此外，Horta博士在高级神经成像数据分析方面的培训 将直接有助于目标2，该目标旨在确认与年龄相关的学习背后的神经回路改变 赤字;再次，将这项工作扩展到慢性疼痛。最后，目标1和2下的分析结果将 直接告知目标3，以确定训练神经回路基础延展性的最佳目标， 脆弱的老年人的信任学习缺陷。