Characterizing and modulating neurocognitive processes of learning to trust and distrust in aging

表征和调节衰老过程中学习信任和不信任的神经认知过程

• 批准号: 10622831
• 负责人: Natalie C Ebner
• 金额: $ 12.32万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622831
• 关键词: Adult; Age; Aging; Behavioral; Clinical; Cognitive; Computer Models; Cues; Data; Data Analyses; Decision Making; Disadvantaged; Elderly; Funding; Goals; Hispanic; Individual; Institution; Latina; Learning; Longevity; Mentors; Neurocognitive; Neurosciences; Population; Process; Psychological reinforcement; Research; Research Personnel; Sampling; Science; Site; Statistical Data Interpretation; Training; Trust; Woman; Work; Writing; career; career development; chronic pain; classical conditioning; clinical pain; disadvantaged background; distrust; neural circuit; neuroimaging; parent grant; research and development; skills; social; trustworthiness

Project Summary (Supplement). This supplement aims to bring Dr. Marilyn Horta, who is from an underrepresented background in the sciences at our institution and in the US, to work under the parent grant R01AG072658. This project offers an ideal context for Dr. Horta's research and career development given her goals of becoming an independent, productive researcher in aging and decision neuroscience. Dr. Horta would have the opportunity to (i) expertise in the identification and optimization of neurocognitive processes of learning to trust and distrust in particularly vulnerable and currently understudied older adult populations (i.e., individuals with chronic pain; disadvantaged groups); (ii) skills in advanced statistical analysis of behavioral and neuroimaging data; and (iii) enhanced presentation and academic writing abilities. Dr. Horta will work closely with her mentoring team that spans across the three parent grant sites and includes balanced expertise in in cognitive and socioemotional experimental aging and neuroimaging analysis (Dr. Ebner), computational modeling of reinforcement and learning (Dr. Wilson), decision neuroscience (Dr. Lighthall), and clinical pain and aging (Dr. Fillingim). On her initiative, Dr. Horta has successfully obtained pilot funding to investigate decision making among older adults with chronic pain, a particularly vulnerable and currently understudied older adult group regarding trust-related decision making. Integrating her clinical expertise in chronic pain populations under the parent grant, Dr. Horta will significantly contribute to all three parent grant aims. In particular, she will advance Aim 1, which is to confirm age deficits in learning to trust in an adult lifespan sample and determine the extent to which social cues of trustworthiness bias trust-related decisions and learning in older adults, by differentiating chronic pain status among the parent grant sample; and with her newly learned skills in computational modeling under the supplement will be able to isolate specific learning biases (e.g., social cue, loss aversion, and recency) under consideration of chronic pain status. Further, Dr. Horta's training in advanced neuroimaging data analysis will directly contribute to Aim 2, which seeks to confirm altered neurocircuitry underlying age-associated learning deficits; again, extending this work to chronic pain. Finally, findings from the analyses under Aims 1 and 2 will directly inform Aim 3 toward identifying the best target for training the malleability of the neurocircuitry underlying trust-learning deficits in vulnerable older adults.

项目摘要（补充）。本增刊旨在将玛丽莲·奥尔塔 (Marilyn Horta) 博士带入 在我们机构和美国，科学背景代表性不足，在家长资助下工作 R01AG072658。该项目为 Horta 博士的研究和职业发展提供了理想的环境 成为衰老和决策神经科学领域独立、富有成效的研究员的目标。霍塔博士会 有机会 (i) 识别和优化学习神经认知过程的专业知识 对特别脆弱且目前未得到充分研究的老年人口（即个人）的信任和不信任 患有慢性疼痛；弱势群体）； (ii) 行为和行为的高级统计分析技能 神经影像数据； (iii) 增强演讲和学术写作能力。奥尔塔博士将密切合作 她的指导团队横跨三个家长资助地点，并包括以下方面的均衡专业知识 认知和社会情感实验衰老和神经影像分析（艾伯纳博士），计算 强化和学习建模（Wilson 博士）、决策神经科学（Lighthall 博士）以及临床疼痛和 衰老（Dr. Fillingim）。在她的倡议下，Horta 博士成功获得了试点资金来调查决策 使患有慢性疼痛的老年人成为特别脆弱且目前尚未得到充分研究的老年人 小组负责与信任相关的决策。将她在慢性疼痛人群中的临床专业知识整合到 在家长补助金中，Horta 博士将为所有三个家长补助金目标做出重大贡献。特别是，她将推进 目标 1，确认成人寿命样本中学习信任的年龄缺陷并确定程度 通过区分，可信度的社会线索会影响老年人与信任相关的决策和学习 家长资助样本中的慢性疼痛状况；以及她新学到的计算建模技能 根据补充将能够隔离特定的学习偏差（例如，社交线索、损失厌恶和新近度） 考虑到慢性疼痛状况。此外，Horta 博士接受过高级神经影像数据分析培训 将直接为目标 2 做出贡献，该目标旨在确认与年龄相关的学习背后的神经回路的改变 赤字；再次，将这项工作扩展到慢性疼痛。最后，目标 1 和 2 下的分析结果将 直接告知目标 3，以确定训练底层神经回路可塑性的最佳目标 弱势老年人的信任学习缺陷。