Research Core 2: Health and Mobility Measures Core (RC2)

项目摘要-健康和移动性指标核心(HMC) 开展与中心主题相关研究的调查人员需要考虑的一个重要问题 而优化储备和韧性是如何选择和实施最合适和最有意义的 措施。健康和移动性测量核心(HMC)将作为中心提供这项服务 为中心调查人员寻求建议、指导、培训和设备以确保有效、敏感和 可靠的全人、非分子测量。由13名成员组成的小组，在以下方面具有互补的专业知识 跨多个领域的测量，构成了核心。HMC将提供高度集成、定制化的 对研究人员的支持由我们的研究教育部分(REC)、试点/探索性研究核心提供支持 (PESC)、外部项目(EP)和由Duke老年美国人参与的更大的Duke社区 独立中心。核心将通过定期会议或根据需要在整个 全方位的项目开发；从早期阶段规划，到对调查结果的最终解释，再到随后 为传播和/或实施提供准备。这些会议将同时有成员参加 分子测量和分析核心，以确保最大的协同作用。HMC将解决三个具体问题 目标。目标1-提供集中的测量专业知识，可供咨询和指导 推进我们对体能储备和韧性的专题调查。目标2-发展测量 在管理和数据收集方面制定协议和培训人员。目标3--找出储备和 复原力衡量，并为相关成果开发和/或采用创新的新衡量方法。 在第一年的资助中，最多将支持三名区域经济合作奖学金获得者和三名PES获奖者。成员 还将为环保企业提供服务，并提出一个创新的发展项目，以扩展 衡量和预测电子健康记录和其他大数据来源的能力。 两个过去成功的讲习班再次提出；一个是提供体能训练，另一个是 功能测试，一个提供动态测量和数据收集方面的培训，以加强 我们受训人员的测量能力。新措施将添加到HMC网站和Duke Pepper 中心研究仪表板将开发并张贴给用户。仪表板是一种交互式数据 可视化仪表板，使OAIC调查人员有机会与聚合的生物标志物和 从OAIC附属研究收集的跨越30年的体能表现数据。仪表板将 为OAIC调查人员提供用于拨款申请的初步数据，以及一个大型的、精心策划的 用于新分析的数据集。HMC将为中心提供无价的服务，这将导致更大的 对储备和复原力的理解，这反过来将指出改善当前和 老年美国人一生中的未来健康和福祉。

PROJECT SUMMARY – Health and Mobility Measures Core (HMC) An important consideration for investigators undertaking studies relevant to the Center theme “To Understand and Optimize Reserve and Resilience” is how to select and implement the most appropriate and meaningful measures. The Health and Mobility Measures Core (HMC) will provide this service by serving as the central resource for Center investigators seeking advice, mentoring, training, and equipment for valid, sensitive, and reliable whole-person, non-molecular measures. A panel of 13 members, with complementary expertise in measurement across multiple domains, comprises the Core. The HMC will provide highly integrated, customized support to investigators supported by our Research Education Component (REC), Pilot/Exploratory Studies Core (PESC), External Projects (EPs), and the larger Duke Community engaged by the Duke Older Americans Independence Center. The Core will support investigators by meeting regularly, or as needed, throughout the full spectrum of project development; from early phase planning, to final interpretation of findings, to subsequent grant preparations to dissemination and/or implementation. These meetings will concurrently involve members of the Molecular Measures and Analysis Cores to ensure maximal synergy. The HMC will address three Specific Aims. Aim 1 - To provide centralized measurement expertise, available for consultation and mentoring to advance our thematic investigations of physical reserve and resilience. Aim 2 - To develop measurement protocols and train personnel in administration and data collection. Aim 3 - To identify gaps in reserve and resiliency measures and develop and/or adapt innovative new measurement approaches for related outcomes. Up to three REC Scholars and three PES awardees will be supported during the first year of funding. Members of the HMC will also provide service to EPs, and propose an innovative Developmental Project to extend measurement and predictive capacity of the electronic health record and other big administrative data sources. Two successful past workshops are proposed again; one to provide training in physical performance and functional testing, and one to provide training in ambulatory measurement and data collection, to augment the measurement capabilities of our trainees. New measures will be added to the HMC website and the Duke Pepper Center Study Dashboard will be developed and posted for users. The dashboard is an interactive data visualization dashboard that gives OAIC investigators the opportunity to interact with aggregated biomarker and physical performance data collected from OAIC-affiliated studies spanning three decades. The Dashboard will provide OAIC investigators with preliminary data to use for grant applications as well as a large, well-curated dataset for new analyses. The HMC will provide an invaluable service to the Center, which will lead to greater understanding of reserve and resilience, and which in turn, will point to opportunities to improve the current and future health and well-being of aging Americans across the lifespan.