Research Core 2: Health and Mobility Measures Core (RC2)

项目摘要 – 健康和流动性措施核心 (HMC) 研究者进行与中心主题“理解”相关的研究的一个重要考虑因素 和优化储备和弹性”是如何选择和实施最合适和最有意义的 措施。健康和流动措施核心 (HMC) 将作为中央部门提供这项服务 为中心调查人员寻求有效、敏感和有效的建议、指导、培训和设备的资源 可靠的全人非分子测量。一个由 13 名成员组成的小组，在以下领域具有互补的专业知识 跨多个领域的测量，包括核心。 HMC将提供高度集成、定制的 通过我们的研究教育部分 (REC)、试点/探索性研究核心为研究人员提供支持 (PESC)、外部项目 (EP) 以及杜克大学老年美国人参与的更大的杜克社区 独立中心。核心将通过在整个过程中定期或根据需要举行会议来支持调查人员 全方位的项目开发；从早期规划，到结果的最终解释，再到后续 为传播和/或实施做好准备。这些会议将同时由成员参加 分子测量和分析核心的结合，以确保最大的协同作用。 HMC 将解决三个具体问题 目标。目标 1 - 提供集中的测量专业知识，可供咨询和指导 推进实物储备和恢复力专题研究。目标 2 - 开发测量 制定管理和数据收集方面的协议并培训人员。目标 3 - 查明储备金和 弹性措施并为相关结果开发和/或采用创新的新测量方法。 在资助的第一年，最多将支持三名 REC 学者和三名 PES 获奖者。会员 HMC 还将为 EP 提供服务，并提出一个创新的发展项目来扩展 电子健康记录和其他大管理数据源的测量和预测能力。 再次提议举办过去两次成功的研讨会；一项提供身体表现方面的培训 功能测试，以及提供动态测量和数据收集培训的一项测试，以增强 我们的学员的测量能力。 HMC 网站和 Duke Pepper 将添加新措施 中心研究仪表板将被开发并发布给用户。仪表板是一个交互式数据 可视化仪表板，使 OAIC 研究人员有机会与聚合的生物标记物进行交互 从 OAIC 附属研究中收集的跨越三十年的身体表现数据。仪表板将 为 OAIC 调查人员提供用于拨款申请的初步数据以及精心策划的大型数据 用于新分析的数据集。 HMC 将为中心提供宝贵的服务，这将带来更多 对储备和复原力的理解，这反过来又会指出改善当前和恢复能力的机会 老年人一生中未来的健康和福祉。

PROJECT SUMMARY – Health and Mobility Measures Core (HMC) An important consideration for investigators undertaking studies relevant to the Center theme “To Understand and Optimize Reserve and Resilience” is how to select and implement the most appropriate and meaningful measures. The Health and Mobility Measures Core (HMC) will provide this service by serving as the central resource for Center investigators seeking advice, mentoring, training, and equipment for valid, sensitive, and reliable whole-person, non-molecular measures. A panel of 13 members, with complementary expertise in measurement across multiple domains, comprises the Core. The HMC will provide highly integrated, customized support to investigators supported by our Research Education Component (REC), Pilot/Exploratory Studies Core (PESC), External Projects (EPs), and the larger Duke Community engaged by the Duke Older Americans Independence Center. The Core will support investigators by meeting regularly, or as needed, throughout the full spectrum of project development; from early phase planning, to final interpretation of findings, to subsequent grant preparations to dissemination and/or implementation. These meetings will concurrently involve members of the Molecular Measures and Analysis Cores to ensure maximal synergy. The HMC will address three Specific Aims. Aim 1 - To provide centralized measurement expertise, available for consultation and mentoring to advance our thematic investigations of physical reserve and resilience. Aim 2 - To develop measurement protocols and train personnel in administration and data collection. Aim 3 - To identify gaps in reserve and resiliency measures and develop and/or adapt innovative new measurement approaches for related outcomes. Up to three REC Scholars and three PES awardees will be supported during the first year of funding. Members of the HMC will also provide service to EPs, and propose an innovative Developmental Project to extend measurement and predictive capacity of the electronic health record and other big administrative data sources. Two successful past workshops are proposed again; one to provide training in physical performance and functional testing, and one to provide training in ambulatory measurement and data collection, to augment the measurement capabilities of our trainees. New measures will be added to the HMC website and the Duke Pepper Center Study Dashboard will be developed and posted for users. The dashboard is an interactive data visualization dashboard that gives OAIC investigators the opportunity to interact with aggregated biomarker and physical performance data collected from OAIC-affiliated studies spanning three decades. The Dashboard will provide OAIC investigators with preliminary data to use for grant applications as well as a large, well-curated dataset for new analyses. The HMC will provide an invaluable service to the Center, which will lead to greater understanding of reserve and resilience, and which in turn, will point to opportunities to improve the current and future health and well-being of aging Americans across the lifespan.