Circuit architecture and dynamics in odor representation and perception

7.项目摘要/摘要。 在哺乳动物的大脑中，早期的感觉区域被组织成刺激性质的刻板地图。这个 这些感觉图的解剖特征是神经元计算和信息处理的基础 对于产生适当的知觉体验和行为是必不可少的。在哺乳动物的嗅觉中 表达相同气味感受器的初级嗅觉神经元(OSN)汇聚轴突 在嗅球内形成相同的岛状肾小球结构。球中的二尖瓣/簇状细胞收到 仅来自单个小球的输入，但它们投射到具有不同输出模式的不同皮质区域。 也有广泛的皮质间连接，但没有明显的解剖标测。情况不太好 了解这种严格的趋同和隔离模式如何对处理 嗅觉信息和气味驱动的行为。也不知道皮质间神经元所起的作用 气味信息过程中的连接。在这个项目中，我们建立了一个多学科的方法来 确定皮质间联系对气味表示和感知的贡献。具体来说，我们 将使用活性标记来确定气味在不同皮质区域的稳定表示，并测试 皮质间相互作用稳定气味表征的假说。

7. Project Summary/Abstract. In the mammalian brain, early sensory areas are organized as stereotyped maps of stimulus qualities. The anatomical features of these sensory maps underlie the neuronal computations and information processing that are essential to generate appropriate perceptual experiences and behaviors. In the mammalian olfactory system primary olfactory sensory neurons (OSNs) expressing the same odorant receptor converge their axons into the same insular glomerular structure in the olfactory bulb. The mitral/tufted cells in the bulb received exclusively input from single glomeruli, but they project to various cortical areas with divergent output patterns. There are also extensive intercortical connections with no apparent anatomical mapping. It is not well understood how this pattern of strict convergence and segregation contributes materially to the processing of olfactory information and odor-driven behaviors. Nor is it understood the role played by the intercortical connections in the process of odor information. In this project, we establish a multi-disciplinary approach to determine the contribution of intercortical connections to odor representation and perception. Specifically, we will use activity marking to determine the stable representation of odors in various cortical areas and test the hypothesis that intercortical interactions stabilize odor representation.