Circuit architecture and dynamics in odor representation and perception

气味表征和感知的电路架构和动力学

• 批准号: 10613409
• 负责人: Thomas A Cleland
• 金额: $ 67.83万
• 依托单位: STOWERS INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613409
• 关键词: Affect; Anatomy; Animal Model; Animals; Architecture; Area; Axon; Behavior; Behavioral Assay; Brain; Categories; Cells; Code; Cognitive deficits; Detection; Deterioration; Discrimination; Discrimination Learning; Funding; Genetic; Goals; Habitats; Image; Interneurons; Label; Learning; Light; Maps; Memory; Mental disorders; Molecular; Mus; Nervous System; Nervous System Physiology; Neurons; Odorant Receptors; Odors; Olfactory Cortex; Olfactory Pathways; Output; Pathologic; Pattern; Perception; Play; Population; Process; Resolution; Role; Sensory; Signal Transduction; Smell Perception; Stable Populations; Stereotyping; Stimulus; Structure; Testing; Tetanus Toxin; Theoretical model; Training; experience; experimental study; genetic approach; information processing; insight; interdisciplinary approach; neural; olfactory bulb; olfactory bulb glomeruli; olfactory sensory neurons; optogenetics; piriform cortex; public health relevance; receptor; response; segregation; sensory system; tool

7. Project Summary/Abstract. In the mammalian brain, early sensory areas are organized as stereotyped maps of stimulus qualities. The anatomical features of these sensory maps underlie the neuronal computations and information processing that are essential to generate appropriate perceptual experiences and behaviors. In the mammalian olfactory system primary olfactory sensory neurons (OSNs) expressing the same odorant receptor converge their axons into the same insular glomerular structure in the olfactory bulb. The mitral/tufted cells in the bulb received exclusively input from single glomeruli, but they project to various cortical areas with divergent output patterns. There are also extensive intercortical connections with no apparent anatomical mapping. It is not well understood how this pattern of strict convergence and segregation contributes materially to the processing of olfactory information and odor-driven behaviors. Nor is it understood the role played by the intercortical connections in the process of odor information. In this project, we establish a multi-disciplinary approach to determine the contribution of intercortical connections to odor representation and perception. Specifically, we will use activity marking to determine the stable representation of odors in various cortical areas and test the hypothesis that intercortical interactions stabilize odor representation.

7.项目概要/摘要。 在哺乳动物的大脑中，早期的感觉区域被组织成刺激质量的刻板地图。的 这些感觉地图的解剖特征是神经元计算和信息处理的基础 这对产生适当的感知体验和行为至关重要。在哺乳动物的嗅觉中 表达相同气味受体的系统初级嗅觉感觉神经元（OSN）会聚它们的轴突 嗅球中的岛状球状结构。球中的二尖瓣/簇状细胞接受 这些神经元仅从单个肾小球输入，但它们以不同的输出模式投射到不同的皮质区。 也有广泛的皮质间连接，没有明显的解剖映射。得不好 了解这种严格收敛和隔离的模式如何对处理做出重大贡献 嗅觉信息和气味驱动的行为。也不知道皮层间神经元所起的作用 气味信息传递过程中的联系。在这个项目中，我们建立了一个多学科的方法， 确定皮质间连接对气味表征和感知的贡献。我们特别 将使用活动标记来确定不同皮层区域中气味的稳定表示，并测试 假设皮层间相互作用稳定气味表征。