Circuit architecture and dynamics in odor representation and perception

气味表征和感知的电路架构和动力学

• 批准号: 10613409
• 负责人: Thomas A Cleland
• 金额: $ 67.83万
• 依托单位: STOWERS INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613409
• 关键词: Affect; Anatomy; Animal Model; Animals; Architecture; Area; Axon; Behavior; Behavioral Assay; Brain; Categories; Cells; Code; Cognitive deficits; Detection; Deterioration; Discrimination; Discrimination Learning; Funding; Genetic; Goals; Habitats; Image; Interneurons; Label; Learning; Light; Maps; Memory; Mental disorders; Molecular; Mus; Nervous System; Nervous System Physiology; Neurons; Odorant Receptors; Odors; Olfactory Cortex; Olfactory Pathways; Output; Pathologic; Pattern; Perception; Play; Population; Process; Resolution; Role; Sensory; Signal Transduction; Smell Perception; Stable Populations; Stereotyping; Stimulus; Structure; Testing; Tetanus Toxin; Theoretical model; Training; experience; experimental study; genetic approach; information processing; insight; interdisciplinary approach; neural; olfactory bulb; olfactory bulb glomeruli; olfactory sensory neurons; optogenetics; piriform cortex; public health relevance; receptor; response; segregation; sensory system; tool

7. Project Summary/Abstract. In the mammalian brain, early sensory areas are organized as stereotyped maps of stimulus qualities. The anatomical features of these sensory maps underlie the neuronal computations and information processing that are essential to generate appropriate perceptual experiences and behaviors. In the mammalian olfactory system primary olfactory sensory neurons (OSNs) expressing the same odorant receptor converge their axons into the same insular glomerular structure in the olfactory bulb. The mitral/tufted cells in the bulb received exclusively input from single glomeruli, but they project to various cortical areas with divergent output patterns. There are also extensive intercortical connections with no apparent anatomical mapping. It is not well understood how this pattern of strict convergence and segregation contributes materially to the processing of olfactory information and odor-driven behaviors. Nor is it understood the role played by the intercortical connections in the process of odor information. In this project, we establish a multi-disciplinary approach to determine the contribution of intercortical connections to odor representation and perception. Specifically, we will use activity marking to determine the stable representation of odors in various cortical areas and test the hypothesis that intercortical interactions stabilize odor representation.

7. 项目总结/摘要。 在哺乳动物的大脑中，早期的感觉区域被组织成刺激质量的刻板图。这 这些感觉图的解剖特征是神经元计算和信息处理的基础 这对于产生适当的感知体验和行为至关重要。在哺乳动物的嗅觉中 系统初级嗅觉感觉神经元（OSN）表达相同的气味受体，汇聚其轴突 进入嗅球中相同的岛状肾小球结构。球茎中的二尖瓣/簇状细胞接收 完全来自单个肾小球的输入，但它们投射到具有不同输出模式的各个皮质区域。 还存在广泛的皮质间连接，但没有明显的解剖学映射。不太好 了解这种严格融合和分离的模式如何对处理 嗅觉信息和气味驱动的行为。我们也不了解皮质间的作用 气味信息过程中的联系。在这个项目中，我们建立了一种多学科方法 确定皮质间连接对气味表征和感知的贡献。具体来说，我们 将使用活动标记来确定不同皮质区域中气味的稳定表现并测试 皮质间相互作用稳定气味表征的假设。