Combined bioprinting with stem cell technology to regenerate skin burn wounds
生物打印与干细胞技术相结合,使皮肤烧伤创面再生
基本信息
- 批准号:10315804
- 负责人:
- 金额:$ 49.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAffectAmericanAnimalsBehaviorBiocompatible MaterialsBiologicalBiological TestingBiologyBody FluidsBurn injuryCell Culture TechniquesCell ProliferationCellsCessation of lifeChemicalsConnective TissueDehydrationEffectivenessEngineeringEpidermisEpithelialEpithelial CellsExtracellular Matrix ProteinsFRAP1 geneFamily suidaeFibroblastsGelatinGenetic TranscriptionHarvestHeterogeneityHomeostasisHousingHumanHydrogelsInfectionInjuryLiftingLiquid substanceMediatingMesenchymeMichiganModificationMolecularNanosphereOrganOsteoblastsPathway interactionsPatientsPlayPolymersProcessQuality of lifeRecombinant ProteinsRecombinantsRecoveryResearchSignal TransductionSiteSkinStratum BasaleStructureSuspensionsTechnologyTestingTherapeuticTimeTissue DonorsTissue EngineeringTranslationsUniversitiesWorkbasebiofabricationbioprintingburn modelburn woundcaprolactonecell motilitydesigndiabetic ulcerepidermal stem cellhealingimprovedin vivoinnovationmeltingnovelnovel therapeutic interventionnovel therapeuticsorgan growthpreventrecruitresponsescaffoldsevere injurysingle cell sequencingskin barrierskin regenerationstem cell technologystem cellstherapeutic effectivenesstissue regenerationtranslation to humanswoundwound closurewound healing
项目摘要
PROJECT SUMMARY
The skin (epidermis) is responsible for protecting the body and works as a specialized, vital defensive barrier.
Upon injury, the immediate response of the epidermis and its stem cells aims to reestablish local homeostasis.
Extensive injuries, often observed in burn patients, compromise the epidermal homeostasis, which leads to
dehydration, possible severe infections, and death. New therapeutic strategies designed to improve healing and
burn injuries are critically needed. Our translation-focused innovative strategy aims to develop mechanism-based
and material engineering-driven therapies to augment epidermal healing. Here, we are developing novel and
exciting biodegradable scaffolds for the controlled delivery of key recombinant proteins and cells to positively
reestablish an epidermal barrier and wound closure. We propose to study how this novel therapeutic strategy
affects the skin stem cells and wound healing process. Furthermore, we will determine the therapeutic
effectiveness of 3D tissue engineering on burn wounds using bioprinting technology. Our positive results will
improve the mechanistic understanding of how patient-originated stem cells and epidermal cells along with 3D
bioprinting contribute to the healing of burn wounds. By accomplishing these specific aims, we will aid in the
management of burn patients, using limited donor tissues and help to reduce burn patients’ recovery time.
项目摘要
皮肤(表皮)负责保护身体,并作为一个专门的,重要的防御屏障。
损伤后,表皮及其干细胞的立即反应旨在重建局部稳态。
在烧伤患者中经常观察到的大面积损伤损害了表皮的稳态,这导致
脱水可能严重感染甚至死亡新的治疗策略旨在改善愈合和
严重烧伤的病人是急需的。我们以预防为重点的创新战略旨在开发基于机制的
和材料工程驱动的疗法来增强表皮愈合。在这里,我们正在开发新的,
令人兴奋的生物可降解支架,用于控制关键重组蛋白和细胞的递送,
重建表皮屏障和伤口闭合。我们建议研究这种新的治疗策略如何
影响皮肤干细胞和伤口愈合过程。此外,我们将确定治疗
使用生物打印技术的3D组织工程对烧伤创面的有效性。我们的积极成果将
提高了对患者来源的干细胞和表皮细胞如何沿着与3D
生物打印有助于烧伤伤口的愈合。通过实现这些具体目标,我们将帮助
管理烧伤病人,使用有限的供体组织,并有助于减少烧伤病人的康复时间。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marco C Bottino其他文献
Marco C Bottino的其他文献
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{{ truncateString('Marco C Bottino', 18)}}的其他基金
Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach
牙周组织再生的个性化策略——融合生物制造方法
- 批准号:
10390983 - 财政年份:2022
- 资助金额:
$ 49.92万 - 项目类别:
Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach
牙周组织再生的个性化策略——融合生物制造方法
- 批准号:
10668946 - 财政年份:2022
- 资助金额:
$ 49.92万 - 项目类别:
Combined bioprinting with stem cell technology to regenerate skin burn wounds
生物打印与干细胞技术相结合,使皮肤烧伤创面再生
- 批准号:
10645037 - 财政年份:2021
- 资助金额:
$ 49.92万 - 项目类别:
Combined bioprinting with stem cell technology to regenerate skin burn wounds
生物打印与干细胞技术相结合,使皮肤烧伤创面再生
- 批准号:
10447161 - 财政年份:2021
- 资助金额:
$ 49.92万 - 项目类别:
A Novel Multilayered Membrane for Periodontal Regeneration
用于牙周再生的新型多层膜
- 批准号:
9527438 - 财政年份:2017
- 资助金额:
$ 49.92万 - 项目类别:
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHES
治疗坏死牙齿的新型疗法:3D 药物输送系统和空间设计的干细胞生态位的组合效应
- 批准号:
10231139 - 财政年份:2017
- 资助金额:
$ 49.92万 - 项目类别:
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHES
治疗坏死牙齿的新型疗法:3D 药物输送系统和空间设计的干细胞生态位的组合效应
- 批准号:
9755401 - 财政年份:2017
- 资助金额:
$ 49.92万 - 项目类别:
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHES
治疗坏死牙齿的新型疗法:3D 药物输送系统和空间设计的干细胞生态位的组合效应
- 批准号:
9982298 - 财政年份:2017
- 资助金额:
$ 49.92万 - 项目类别:
A Novel Multilayered Membrane for Periodontal Regeneration
用于牙周再生的新型多层膜
- 批准号:
8879976 - 财政年份:2013
- 资助金额:
$ 49.92万 - 项目类别:
A Novel Multilayered Membrane for Periodontal Regeneration
用于牙周再生的新型多层膜
- 批准号:
8692736 - 财政年份:2013
- 资助金额:
$ 49.92万 - 项目类别:
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