Increasing the size of the specific pathogen free Indian rhesus macaques colony at the Southwest National Primate Research Center for AIDS, COVID-19 and other infectious diseases research

扩大西南国家灵长类动物研究中心的无特定病原体印度恒河猴群体规模，以进行艾滋病、COVID-19 和其他传染病研究

• 批准号: 10313857
• 负责人: Larry S. Schlesinger
• 金额: $ 89.43万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-06 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10313857
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Address; Animals; Antibodies; Area; Asia; Breeding; COVID-19; COVID-19 pandemic; Callithrix; Communicable Diseases; Disease; Emergency Situation; Funding; Future; Goals; Health; Human; Infectious Diseases Research; Influenza; Intervention; Lyme Disease; Macaca; Macaca mulatta; Metabolic Diseases; Modeling; Neurosciences; Papio; Pertussis; Population; Prevention; Primates; Production; Readiness; Research; Research Personnel; Rhesus; SARS-CoV-2 infection; Time; Tuberculosis; United States National Institutes of Health; Zika Virus; building renovation; germ free condition; infectious disease model; infectious disease treatment; model development; nonhuman primate; pandemic disease; pathogen; response; vaccine development; virtual

Abstract. Specific pathogen free (SPF) Indian origin Macaca mulatta (rhesus macaques) are the premier model for infectious disease research including HIV/AIDS, TB, influenza, Lyme disease, and now COVID-19. There has been an acute nationwide shortage of these animals over the past couple of decades, which has been well- documented. Multiple reasons related to the COVID-19 pandemic have made this situation more difficult. Imports of these animals from Asia have stopped, and biomedical corporates have used large number of these animals in the past year. A number of animals have also been used in COVID-19 research by investigators at virtually each of the seven National Primate Research Centers (NPRCs). Hence, there is an acute, urgent need to increase the availability of SPF Indian origin rhesus macaques. This application proposes to increase the production of these animals at the Southwest National Primate Research Center (SNPRC).

抽象的。 无特定病原体（SPF）的印度起源猕猴（恒河猴）是 传染病研究，包括艾滋病毒/艾滋病、结核病、流感、莱姆病和现在的COVID-19。一直 在过去的几十年里，这些动物在全国范围内严重短缺，这是很好的- 记录在案。与COVID-19疫情相关的多个原因令情况更加困难。进口 来自亚洲的这些动物已经停止，生物医学公司已经使用大量这些动物 过去一年许多动物也被研究人员用于COVID-19研究， 七个国家灵长类动物研究中心（NPRCs）。因此，迫切需要 增加SPF印度恒河猴的可用性。本申请建议增加 这些动物的生产在西南国家灵长类动物研究中心（SNPRC）。