Shared Resource 03: Biostatistics (BSR)

共享资源 03：生物统计学 (BSR)

• 批准号: 10333291
• 负责人: Soledad A Fernandez
• 金额: $ 32.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333291
• 关键词: Abbreviations; Adverse event; Area; Artificial Intelligence; Basic Science; Bioconductor; Biological; Biometry; Biostatistics Shared Resource; Budgets; Cancer Biology; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Cancer Survivorship; Center for Translational Science Activities; Chemoprevention; Clinical; Clinical Cancer Center; Clinical Data; Clinical Sciences; Clinical Treatment; Clinical Trials; Collaborations; Communities; Comparative Pathology; Comprehensive Cancer Center; Data; Data Analyses; Databases; Development; Disease; Education; Educational workshop; Electronic Health Record; Engineering; Ensure; FAIR principles; Faculty; Flow Cytometry; Funding; Future; Genomics; Grant; Guidelines; Health Insurance Portability and Accountability Act; Health Services Research; Hour; Immunologic Monitoring; Immunooncology; Individual; Informatics; Infrastructure; Institutes; Institutional Review Boards; Intervention; Intramural Research Program; Logistics; Machine Learning; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuscripts; Methodology; Methods; Microscopy; Mission; Modeling; Molecular Carcinogenesis; Monitor; Multi-Institutional Clinical Trial; NCI Center for Cancer Research; Nutrient; Ohio; Oncology; Outcomes Research; Pediatric Hospitals; Persons; Pharmaceutical Chemistry; Phytochemical; Population Research; Population Study; Preparation; Procedures; Process; Proteomics; Protocols documentation; Publications; Publishing; Registries; Reporting; Reproducibility; Research; Research Activity; Research Design; Research Institute; Research Methodology; Research Personnel; Resource Sharing; Resources; Review Committee; Role; Safety; Science; Scientist; Services; Statistical Data Interpretation; Surveys; System; Technology; Training; Training and Education; Translational Research; United States National Institutes of Health; Universities; Work; animal imaging; anticancer research; base; biomedical informatics; cancer care; cancer prevention; data quality; data visualization; design; digital imaging; epidemiology study; experimental study; genomic data; health disparity; innovation; leukemia; leukemia tissue bank; material transfer agreement; member; multidimensional data; next generation sequencing; pathology imaging; patient oriented; population based; professor; programs; query tools; ranpirnase; recruit; research study; single-cell RNA sequencing; sound; tool; translational genomics; translational therapeutics; working group

PROJECT SUMMARY – BIOSTATISTICS SHARED RESOURCE (BSR) The BSR provides a centralized resource of expertise in the biostatistical and design aspects of clinical/translational, basic, and population-based cancer research. The specific aims of the BSR are to: 1) collaborate with OSUCCC investigators in all aspects of quantitative translational research including study design, training and education, reproducibility and scientific rigor, statistical analysis, data visualization, and manuscript and report preparation; 2) enable strong and consistent collaborations by providing a biostatistical “navigator” to all OSUCCC research programs and Disease Specific Research Groups (DSRGs), and by providing education and biostatistical training to OSUCCC members; and 3) provide biostatistical and methodological review of all cancer protocols submitted to the OSUCCC Clinical Scientific Review Committee (CSRC) and Data Safety Monitoring Committee (DSMC), and as needed for the Total Cancer Care (TCC) research committee for the BSSR. To bolster team science in cancer research, BSR established a navigator- system in 2013, now expanded over the current cycle to 20 different groups at OSU and Nationwide Children's Hospital (NCH), whereby biostatisticians are embedded within each DSRG and are involved with all research studies from their inception. Navigators are intimately familiar with the clinical, biological, and statistical issues they support and serve as point persons for establishing collaborations between these groups and the broader OSU community. Office hours were established within all five OSUCCC programs, where the navigator biostatistician spends half a day every other week at a provided space. BSR also actively developed workshops, seminars, and courses devoted to training biomedical investigators in the fundamentals of design, analysis, and scientific rigor. Over the current cycle, BSR supported individual investigators using genomic data from the TCC protocol, the Oncology Research Information Exchange Network (ORIEN) Avatar program at OSU, and the National Patient-Centered Research Clinical Network (PaTH) by providing computational and programming support, data visualization, graphical and query tools, and data interpretation. BSR works together with other shared resources and the DSMC and CSRC in the development and implementation of protocols to ensure HIPAA compliant processes, and high data quality by enforcing the application of Findable, Accessible, Interoperable, and Reusable (FAIR) guidelines. During the current cycle, the BSR supported 405 publications (59 > 10 impact factor) and 98 NIH (53 NCI) grants including 26 R01s, 35 R21s, 1 R03, 14 U01s, 5 U24s, 3 U19s, 3 U54s, 8 P01s, 2 P30s, 1 P50. Over the next grant cycle, the BSR's role in the new strategic priorities for the OSUCCC, including immuno-oncology, translational genomics, cancer engineering and cancer prevention and survivorship will substantially increase the BSR's contributions, and will specifically include new recruits and technologies. The annual budget of the BSR is $4,063,515, yet the CCSG request is $231,260. As such, the BSR leverages extensive institutional support and seeks only 5.7% support from CCSG funds.

项目摘要 – 生物统计共享资源 (BSR) BSR 提供​​生物统计和设计方面的集中专业知识资源 临床/转化、基础和基于人群的癌症研究。 BSR 的具体目标是： 1) 与 OSUCCC 研究人员在定量转化研究的各个方面进行合作，包括研究 设计、培训和教育、可重复性和科学严谨性、统计分析、数据可视化和 手稿和报告的准备； 2）通过提供生物统计数据来实现强有力和一致的合作 所有 OSUCCC 研究项目和疾病特定研究小组 (DSRG) 的“导航员”，以及 为 OSUCCC 成员提供教育和生物统计培训； 3）提供生物统计和 对提交给 OSUCCC 临床科学审查委员会的所有癌症方案进行方法学审查 (CSRC) 和数据安全监测委员会 (DSMC)，以及根据全面癌症护理 (TCC) 的需要 BSSR研究委员会。为了支持癌症研究中的团队科学，BSR 建立了一个导航器 - 系统于 2013 年推出，现已在本周期扩展到 OSU 和全国儿童医院的 20 个不同小组 医院 (NCH)，生物统计学家隶属于每个 DSRG 并参与所有研究 从一开始就进行研究。导航员非常熟悉临床、生物学和统计问题 他们支持并充当在这些团体和更广泛的群体之间建立合作的关键人物 俄勒冈州立大学社区。所有五个 OSUCCC 项目均规定了办公时间，其中导航员 生物统计学家每隔一周在提供的空间呆上半天。 BSR还积极开展研讨会， 致力于培训生物医学研究人员设计、分析和分析基础知识的研讨会和课程 科学严谨。在当前周期中，BSR 使用 TCC 的基因组数据为个别研究人员提供支持 协议、俄勒冈州立大学肿瘤学研究信息交换网络 (ORIEN) Avatar 计划以及 国家以患者为中心的研究临床网络 (PaTH) 通过提供计算和编程 支持、数据可视化、图形和查询工具以及数据解释。 BSR 与其他合作伙伴一起工作 在协议的制定和实施过程中与 DSMC 和 CSRC 共享资源，以确保 通过强制应用可查找、可访问、符合 HIPAA 的流程和高数据质量， 可互操作和可重用 (FAIR) 准则。在本周期内，BSR 支持了 405 篇出版物 （59 > 10 影响因子）和 98 项 NIH (53 NCI) 资助，包括 26 R01、35 R21、1 R03、14 U01、5 U24、3 U19、3 架 U54、8 架 P01、2 架 P30、1 架 P50。在下一个拨款周期中，BSR 在新的战略优先事项中的作用 OSUCCC，包括免疫肿瘤学、转化基因组学、癌症工程和癌症预防 幸存者将大幅增加 BSR 的贡献，特别包括新招募的人员和 技术。 BSR 的年度预算为 4,063,515 美元，而 CCSG 的请求为 231,260 美元。因此， BSR 利用广泛的机构支持，仅寻求 CCSG 基金 5.7% 的支持。