Shared Resource 03: Biostatistics (BSR)

共享资源 03：生物统计学 (BSR)

• 批准号: 10553335
• 负责人: Soledad A Fernandez
• 金额: $ 32.86万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553335
• 关键词: Abbreviations; Adverse event; Area; Artificial Intelligence; Bioconductor; Biological; Biometry; Biostatistics Shared Resource; Budgets; Cancer Biology; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Cancer Survivorship; Center for Translational Science Activities; Chemoprevention; Clinical; Clinical Cancer Center; Clinical Data; Clinical Sciences; Clinical Treatment; Clinical Trials; Collaborations; Communities; Comparative Pathology; Comprehensive Cancer Center; Data; Data Analyses; Databases; Development; Disease; Education; Educational workshop; Electronic Health Record; Engineering; Ensure; FAIR principles; Faculty; Flow Cytometry; Funding; Future; Genomics; Grant; Guidelines; Health Insurance Portability and Accountability Act; Health Services Research; Hour; Immunologic Monitoring; Immunooncology; Individual; Informatics; Infrastructure; Institution; Institutional Review Boards; Intervention; Intramural Research Program; Logistics; Machine Learning; Malignant Childhood Neoplasm; Malignant Neoplasms; Manuscripts; Methodology; Methods; Microscopy; Mission; Modeling; Molecular Carcinogenesis; Monitor; Multi-Institutional Clinical Trial; NCI Center for Cancer Research; Nutrient; Ohio; Oncology; Outcomes Research; Pediatric Hospitals; Persons; Pharmaceutical Chemistry; Phytochemical; Population Research; Population Study; Preparation; Procedures; Process; Proteomics; Protocols documentation; Publications; Publishing; Registries; Reporting; Reproducibility; Research; Research Activity; Research Design; Research Institute; Research Methodology; Research Personnel; Resource Sharing; Resources; Review Committee; Role; Safety; Science; Scientist; Services; Statistical Data Interpretation; Surveys; System; Technology; Training; Training and Education; Translational Research; United States National Institutes of Health; Universities; Work; animal imaging; anticancer research; biomedical informatics; cancer care; cancer prevention; clinical translation; data quality; data visualization; design; digital imaging; epidemiology study; experimental study; genomic data; health disparity; innovation; leukemia; leukemia tissue bank; material transfer agreement; member; multidimensional data; next generation sequencing; pathology imaging; patient oriented; population based; professor; programs; query tools; recruit; research study; single-cell RNA sequencing; sound; tool; translational genomics; translational therapeutics; working group

PROJECT SUMMARY – BIOSTATISTICS SHARED RESOURCE (BSR) The BSR provides a centralized resource of expertise in the biostatistical and design aspects of clinical/translational, basic, and population-based cancer research. The specific aims of the BSR are to: 1) collaborate with OSUCCC investigators in all aspects of quantitative translational research including study design, training and education, reproducibility and scientific rigor, statistical analysis, data visualization, and manuscript and report preparation; 2) enable strong and consistent collaborations by providing a biostatistical “navigator” to all OSUCCC research programs and Disease Specific Research Groups (DSRGs), and by providing education and biostatistical training to OSUCCC members; and 3) provide biostatistical and methodological review of all cancer protocols submitted to the OSUCCC Clinical Scientific Review Committee (CSRC) and Data Safety Monitoring Committee (DSMC), and as needed for the Total Cancer Care (TCC) research committee for the BSSR. To bolster team science in cancer research, BSR established a navigator- system in 2013, now expanded over the current cycle to 20 different groups at OSU and Nationwide Children's Hospital (NCH), whereby biostatisticians are embedded within each DSRG and are involved with all research studies from their inception. Navigators are intimately familiar with the clinical, biological, and statistical issues they support and serve as point persons for establishing collaborations between these groups and the broader OSU community. Office hours were established within all five OSUCCC programs, where the navigator biostatistician spends half a day every other week at a provided space. BSR also actively developed workshops, seminars, and courses devoted to training biomedical investigators in the fundamentals of design, analysis, and scientific rigor. Over the current cycle, BSR supported individual investigators using genomic data from the TCC protocol, the Oncology Research Information Exchange Network (ORIEN) Avatar program at OSU, and the National Patient-Centered Research Clinical Network (PaTH) by providing computational and programming support, data visualization, graphical and query tools, and data interpretation. BSR works together with other shared resources and the DSMC and CSRC in the development and implementation of protocols to ensure HIPAA compliant processes, and high data quality by enforcing the application of Findable, Accessible, Interoperable, and Reusable (FAIR) guidelines. During the current cycle, the BSR supported 405 publications (59 > 10 impact factor) and 98 NIH (53 NCI) grants including 26 R01s, 35 R21s, 1 R03, 14 U01s, 5 U24s, 3 U19s, 3 U54s, 8 P01s, 2 P30s, 1 P50. Over the next grant cycle, the BSR's role in the new strategic priorities for the OSUCCC, including immuno-oncology, translational genomics, cancer engineering and cancer prevention and survivorship will substantially increase the BSR's contributions, and will specifically include new recruits and technologies. The annual budget of the BSR is $4,063,515, yet the CCSG request is $231,260. As such, the BSR leverages extensive institutional support and seeks only 5.7% support from CCSG funds.

项目总结-生物统计学共享资源（BSR） BSR提供了生物统计和设计方面的集中专业知识资源， 临床/转化、基础和基于人群的癌症研究。BSR的具体目标是：1） 与OSUCCC研究人员在定量转化研究的各个方面进行合作，包括研究 设计、培训和教育、可重复性和科学严谨性、统计分析、数据可视化，以及 手稿和报告准备; 2）通过提供生物统计学 “导航”所有OSUCCC研究计划和疾病特异性研究小组（DSRG），并通过 为OSUCCC成员提供教育和生物统计培训;以及3）提供生物统计和 对提交给OSUCCC临床科学审查委员会的所有癌症方案进行方法学审查 （CSRC）和数据安全性监测委员会（DSMC），以及根据癌症全面护理（TCC）的需要 BSSR的研究委员会。为了支持癌症研究中的团队科学，BSR建立了一个导航器- 系统在2013年，现在扩大到20个不同的群体在俄勒冈州立大学和全国儿童的 医院（NCH），其中生物统计学家嵌入每个DSRG，并参与所有研究 从他们的研究开始。导航员非常熟悉临床、生物学和统计学问题 他们支持并充当在这些团体和更广泛的 OSU社区所有五个OSUCCC项目都规定了办公时间， 生物统计学家每隔一周花半天时间在一个提供的空间。BSR还积极开展研讨会， 专门培训生物医学研究人员设计、分析和技术基础的研讨会和课程 科学严谨在当前的周期中，BSR支持个体研究者使用TCC的基因组数据 协议，OSU的肿瘤学研究信息交换网络（ORIEN）头像计划，以及 国家以患者为中心的研究临床网络（PaTH），通过提供计算和编程 支持、数据可视化、图形和查询工具以及数据解释。BSR与其他 共享资源和DSMC和CSRC在开发和实施协议，以确保 通过实施Findable、Discriminable、 互操作和可重用（FAIR）准则。在本周期内，基础结构审查支持了405份出版物 (59> 10个影响因子）和98个NIH（53个NCI）赠款包括26个R 01，35个R21，1个R 03，14个U 01，5个U24，3个 U19，3 U54，8 P01，2 P30，1 P50。在下一个赠款周期，BSR在新的战略优先事项中的作用， OSUCCC，包括免疫肿瘤学，翻译基因组学，癌症工程和癌症预防 和幸存者将大大增加BSR的贡献，并将特别包括新招募， 技术. BSR的年度预算为4，063，515美元，而CCSG的要求为231，260美元。因此， BSR利用广泛的机构支持，仅寻求CCSG基金的5.7%支持。