Biostatistics Shared Resource

核心-007：生物统计共享资源(BSR) 项目摘要/摘要 生物统计共享资源(BSR)为俄亥俄州立大学综合癌症中心提供 (OSUCCC)拥有生物统计专门知识的集中资源的调查人员。BSR由Dr。 Soledad Fernandez和副主任是Kevin Coombes博士(TT)。有关统计问题，请访问 所有级别的调查，从实验设计到数据质量的维护，以及从 结论基于对通过数据探索发现的重要线索的形式假设检验。在支持中 对于这一目标，本资源的具体目的是：1)与OSUCCC调查人员在所有方面进行合作 生物医学研究的各个方面：设计、实施和发现；2)使强大和一致 合作，为所有OSUCCC项目和疾病组提供生物统计学“导航器”；以及3) 提供提交给临床科学委员会的所有癌症方案的生物统计和方法学审查 中国证监会(CSRC)和数据安全监测委员会(DSMC)，并为 Biosecimen服务共享资源及其全面癌症护理协议。在过去的五年里，BSR 加强了与OSUCCC所有计划的整合和合作。BSR的主要亮点 上一个供资期间的活动包括：1)BSR生物统计学家资助了254篇与癌症有关的论文 其中14个指标具有期刊影响因子&>10。这些指标代表着 自从我们上次拨款以来的出版物。2)BSR成员得到11个续订方案和3个新方案的支持 赠款，包括NCI资助的第一个甲状腺癌孢子和36个R01。3)BSR额外雇用了9名员工 支持OSUCCC调查人员的生物统计学家，包括前OSUCCC主任Kevin Coombes(TT)博士 医学安德森癌症中心生物信息学共享资源。其他新兵提高了我们的临床水平 具有贝叶斯方法的试验专业知识。4)BSR实施了新的生物统计导航器模型，以 扩大、改进和统一对OSUCCC调查人员的支持，同时保持对广泛的 拥有俄亥俄州立大学不同学院的其他生物统计学家的专业知识。5)BSR增加了与 疾病特异性研究通过为每一组指派一名专门的生物统计师来对DSRGs进行分组。6)BSR 将支持与其他共享资源集成，如生物医学信息学共享资源、基因组学 共享资源、药物分析共享资源、分析细胞学共享资源和 行为测量共享资源。7)BSR成员提供教育并宣传其益处 向OSUCCC研究人员提供早期临床试验的创新设计。BSR利用广泛的 机构支持，仅从CCSG基金寻求7.7%的支持。生物统计共享资源是 数量分组的一部分。

CORE-007: BIOSTATISTICS SHARED RESOURCE (BSR) PROJECT SUMMARY / ABSTRACT The Biostatistics Shared Resource (BSR) provides The Ohio State University Comprehensive Cancer Center (OSUCCC) investigators with a centralized resource for biostatistical expertise. The BSR is directed by Dr. Soledad Fernandez and the Associate Director is Dr. Kevin Coombes (TT). Statistical issues are addressed at all levels of investigation, from the design of experiments to the maintenance of data quality, and from conclusions based on formal hypothesis testing to important leads discovered by data exploration. In support of this objective, the Specific Aims of this resource are to: 1) collaborate with OSUCCC investigators in all aspects of biomedical research: design, implementation and discovery; 2) enable strong and consistent collaborations by providing a biostatistical “navigator” to all OSUCCC programs and disease groups; and 3) provide biostatistical and methodological review of all cancer protocols submitted to the Clinical Scientific Review Committee (CSRC) and the Data Safety Monitoring Committee (DSMC), and to provide support to the Biospecimen Services Shared Resource and its Total Cancer Care protocol. Over the past five years, the BSR has increased its integration and collaborations with all OSUCCC programs. The main highlights of BSR activities during the last funding period include: 1) BSR biostatisticians supported 254 cancer-related papers and 14 of these had a journal impact factor >10. These metrics represent a 33% increase in number of publications since our last grant. 2) BSR members received support from 11 renewed and 3 new programmatic grants, including the first NCI-funded Thyroid Cancer SPORE and also 36 R01s. 3) BSR hired nine additional biostatisticians to support OSUCCC investigators, including Dr. Kevin Coombes (TT), former Director of the Bioinformatics Shared Resource at MD Anderson Cancer Center. Other recruits have enhanced our clinical trials expertise with Bayesian methodologies. 4) BSR implemented a new biostatistical navigator model to expand, improve and unify support to OSUCCC investigators while maintaining access to the wide breadth of expertise with other biostatisticians across different OSU colleges. 5) The BSR increased its interactions with the Disease Specific Research Groups DSRGs by assigning a dedicated biostatistician to each group. 6) BSR integrates support with other shared resources, such as Biomedical Informatics Shared Resource, Genomics Shared Resource, Pharmacoanalytical Shared Resource, Analytical Cytometry Shared Resource and Behavioral Measurement Shared Resource. 7) BSR members provided education and promoted the benefits of innovative designs for early phase clinical trials to OSUCCC investigators. The BSR leverages extensive institutional support, and seeks only 7.7% support from CCSG funds. The Biostatistics Shared Resource is part of the Quantitative Grouping.