Biostatistic Core

生物统计核心

• 批准号: 8561794
• 负责人: Soledad A Fernandez
• 金额: $ 13.09万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8561794
• 关键词: Address; Adopted; Biological; Biometry; Biostatistics Core; Clinical; Collaborations; Complex; Data; Data Analyses; Data Display; Data Quality; Decision Making; Drug Formulations; Ensure; Experimental Designs; Inferior; Investigation; Lead; Literature; Maintenance; Mammary Neoplasms; Measurement; Methodology; Methods; Modeling; Outcome Measure; Play; Population Study; Procedures; Reporting; Research; Research Personnel; Resources; Role; Sample Size; Sampling; Security; Services; Staging; Statistical Methods; Statistical Models; Statistical Study; Statistical sensitivity; Testing; Thinking; Validation; Visual; Work; Writing; base; data integration; data integrity; data management; design; expectation; experience; genetic analysis; meetings; primary outcome; repository; research study; success; tumor microenvironment

The principal objective of the Biostatistics Core will be to provide project investigators a centralized resource for biostatistics expertise. Statistical issues will be addressed at all levels of investigation: from the design of experiments, to the maintenance of data quality; and from conclusions based on formal hypothesis testing, to important leads discovered by thorough data exploration. In support of this objective, the specific aims of the Core include: 1. Collaborate with project investigators in the formulation of unambiguous hypotheses and hypothesis testing strategies, and in the design of experiments and population studies. 2. Provide support for all projects with: formal hypothesis tests in experimental data that ensure strong conclusions; exploratory analyses that lead to further experiments, refined hypotheses, or discoveries; frequent collaborative meetings about refining design, sample size, and resource use as evidence is accumulated; statistical modeling and sensitivity analyses of complex data; and visual displays of data that clarify conclusions and uncover leads. 3. Provide data transfer, management, and integration services that ensure high integrity, security and investigator accessibility. 4. Investigate new methodologies to directly address difficult data or design problems.

生物统计核心的主要目标将是为项目调查员提供集中的资源 生物统计学方面的专业知识。统计问题将在所有级别的调查中得到解决：从设计 实验，到数据质量的维护；以及从基于形式假设检验的结论，到 通过彻底的数据探索发现的重要线索。为支持这一目标，委员会的具体目标 核心包括： 1.与项目调查人员合作，制定明确的假设和假设 测试策略，以及实验和人口研究的设计。 2.为所有项目提供支持：在实验数据中进行正式假设检验，以确保 结论；导致进一步实验、改进假设或发现的探索性分析； 作为证据，经常召开关于改进设计、样本大小和资源使用的协作会议 累积；复杂数据的统计建模和敏感性分析；以及数据的可视化显示 澄清结论并发现线索。 3.提供数据传输、管理和集成服务，确保高度完整性、安全性和 调查员可访问性。 4.研究直接解决疑难数据或设计问题的新方法。