Biostatistic Core

生物统计学核心的主要目标是为项目研究者提供集中的资源 生物统计学专业知识。统计问题将在调查的各个层面得到解决：从设计 实验，以维护数据质量;并从基于正式假设检验的结论，以 通过彻底的数据探索发现重要线索。为支持这一目标， 核心包括： 1.与项目调查人员合作，制定明确的假设和假说 测试策略，并在实验和人口研究的设计。 2.为所有项目提供支持：在实验数据中进行正式假设检验， 结论;探索性分析，导致进一步的实验，完善的假设，或发现; 经常召开关于改进设计、样本大小和资源使用的协作会议， 复杂数据的统计建模和敏感性分析;以及数据的直观显示 来澄清结论和发现线索。 3.提供数据传输、管理和集成服务，确保高度完整性、安全性和 调查员可访问性。 4.研究新的方法来直接解决困难的数据或设计问题。

The principal objective of the Biostatistics Core will be to provide project investigators a centralized resource for biostatistics expertise. Statistical issues will be addressed at all levels of investigation: from the design of experiments, to the maintenance of data quality; and from conclusions based on formal hypothesis testing, to important leads discovered by thorough data exploration. In support of this objective, the specific aims of the Core include: 1. Collaborate with project investigators in the formulation of unambiguous hypotheses and hypothesis testing strategies, and in the design of experiments and population studies. 2. Provide support for all projects with: formal hypothesis tests in experimental data that ensure strong conclusions; exploratory analyses that lead to further experiments, refined hypotheses, or discoveries; frequent collaborative meetings about refining design, sample size, and resource use as evidence is accumulated; statistical modeling and sensitivity analyses of complex data; and visual displays of data that clarify conclusions and uncover leads. 3. Provide data transfer, management, and integration services that ensure high integrity, security and investigator accessibility. 4. Investigate new methodologies to directly address difficult data or design problems.