Delaware Center for Musculoskeletal Research – Multiscale Assessments Research Core

特拉华州肌肉骨骼研究中心 — 多尺度评估研究核心

• 批准号: 10352303
• 负责人: LIYUN WANG
• 金额: $ 73.35万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352303
• 关键词: Animals; Basic Science; Biological; Biological Models; Biological Sciences; Biomechanics; Biomedical Research; Biophysics; Biostatistics Core; Biotechnology; Communities; Competence; Computers and Advanced Instrumentation; Cues; Delaware; Disease; Educational workshop; Engineering; Ensure; Equipment; Functional disorder; Funding; Goals; Health; Image; Individual; Institutes; Lead; Leadership; Measurement; Methodology; Molecular; Musculoskeletal; Organism; Pre-Clinical Model; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Services; Signal Transduction; Structure; Technical Expertise; Techniques; Therapeutic Intervention; Tissues; Training; Universities; Work; bioimaging; biomechanical model; biophysical model; design; in vivo imaging; instrument; instrumentation; mechanical load; pre-clinical; pre-clinical research; programs; response; square foot; success

Project Summary / Abstract The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. Unraveling the interconnected responses at multiple levels will require an integrated application of advanced biomechanical and bioimaging techniques with preclinical (animal) and biophysical (explant) model systems. This requirement is not easily met using standard instrumentation typically available in research centers, and state-of-the-art equipment, technical expertise to use this equipment, and scientific expertise across multiple platforms to guide the design and application of these techniques is needed. The goal of the Multiscale Assessments Research Core is to maximize the success and impact of DCMR Research Project, Project Leaders, and other researchers by providing a Research Core that includes state-of- the-art equipment to apply and assess physical cues and biological signals. The Core will use a gateway organizational framework that is built around interlinked scientific leadership, technical expertise, user training, and partnerships with existing collaborative Centers. The Research Core will provide, develop, and support multiscale mechanical loading and measurement capability, expertise, and training (Aim 1); provide, develop, and support preclinical and biophysical models, including assessment capability, expertise, and training (Aim 2); and enhance the existing Bioimaging Center (Aim 3). The Research Core will obtain new state-of-the-art equipment, including the construction of new instruments to apply physical cues and molecular signals to living systems and the purchase of advanced instrumentation for in vivo imaging. The Research Core will be housed in a newly renovated 1400 sq. ft. lab space adjacent to the vivarium. The coordination of musculoskeletal resources and expertise in the DCMR Multiscale Assessments Research Core will accelerate the research pace for Project Leaders and Center users. The use of Core’s resources for research questions at the interface of engineering and life sciences will have a synergistic effect that will strengthen UD’s biomedical research infrastructure and impact.

项目总结/摘要 特拉华州肌肉骨骼研究中心（DCMR）将支持以下基础和临床前研究： 肌肉骨骼健康和疾病的中心主题，从整个身体的水平到分子， 强调物理和生物线索影响组织结构和正常组织的机制， 功能、功能障碍和潜在的治疗干预。解开相互关联的反应， 多个层面将需要先进的生物力学和生物成像技术的综合应用， 临床前（动物）和生物物理（外植体）模型系统。这一要求不容易满足使用标准 仪器通常可在研究中心，和国家的最先进的设备，技术专长，以使用 这种设备，以及跨多个平台的科学专业知识，以指导这些设备的设计和应用。 技术是需要的。 多尺度评估研究核心的目标是使DCMR的成功和影响最大化 研究项目，项目负责人和其他研究人员通过提供一个研究核心，其中包括国家的， 最先进的设备来应用和评估物理线索和生物信号。核心会使用一个网关 围绕相互关联的科学领导、技术专长、用户培训、 与现有合作中心的合作。研究中心将提供、开发和支持 多尺度机械加载和测量能力，专业知识和培训（目标1）;提供，开发， 并支持临床前和生物物理模型，包括评估能力、专业知识和培训（Aim 2）;并加强现有的生物成像中心（目标3）。 研究核心将获得新的最先进的设备，包括建造新的仪器 将物理线索和分子信号应用于生命系统，并购买先进的仪器 用于体内成像。研究核心将设在一个新装修的1400平方米。英尺实验室空间毗邻 动物园DCMR多尺度评估中肌肉骨骼资源和专业知识的协调 Research Core将加快项目负责人和中心用户的研究步伐。使用Core 工程学和生命科学之间的研究问题资源将产生协同效应 这将加强UD的生物医学研究基础设施和影响力。