Subcortical auditory processing in sports-related concussions and contact/collision sports

运动相关脑震荡和接触/碰撞运动中的皮层下听觉处理

• 批准号: 10352314
• 负责人: NINA KRAUS
• 金额: $ 53.89万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10352314
• 关键词: Acute; Affect; Age; Athletic; Attention; Auditory; Auditory system; Behavioral; Berlin; Biological Markers; Brain Concussion; Child; Clinical; Cognitive; Collaborations; Consensus; Craniocerebral Trauma; Data; Diagnosis; Elderly; Electrophysiology (science); Emotional; Evoked Potentials; Exhibits; Eye; Field Hockey; Fingerprint; Frequencies; Future; Goals; Grain; Guidelines; HIV; Health; Health system; Individual; Injury; Learning; Longitudinal Studies; Manufactured Baseball; Manufactured football; Measures; Monitor; Nature; Nervous System Physiology; Neuraxis; Neurologic; Outcome Measure; Participant; Patient Self-Report; Patients; Phase; Physicians; Physiological; Play; Population; Prevention; Proxy; Recovery; Rehabilitation therapy; Risk; Seasons; Sensory; Sleep; Speech; Sports; Sports Medicine; Tennis; Testing; Time; Universities; Woman; Work; auditory processing; base; career; cognitive skill; cognitive testing; cohort; college; contact sports; deviant; diagnostic criteria; head impact; imprint; insight; longitudinal design; member; men; neuromechanism; neurophysiology; novel strategies; peer; potential biomarker; prospective; racial diversity; relating to nervous system; research clinical testing; response; sex; socioeconomics; speech in noise; student athlete; university student; visual-vestibular; young adult

Abstract Because diagnostic criteria of concussion rely upon self-reporting—which may be unreliable in a recently concussed individual—the goal of this project is to identify a neural marker of concussion that does not require effort from the patient. Concussion adversely affects many domains and there is strong reason to believe, and preliminary data to support, that neural processing in the auditory system is negatively influenced by sports- related concussion. By using an objective electrophysiological measure of auditory processing, this work has strong potential to broaden the understanding of concussion's effect on sensory processing and to eliminate a major pitfall in diagnosis and management of concussion. This proposal uses a novel approach to understand the impact of head injury on sensory processing: the frequency-following response (FFR) to speech. The central hypothesis is this objective neurophysiological measure of auditory processing serves as a marker of disruptions to central nervous system function following concussion. In collaboration with Northwestern University Athletics, this is a prospective, longitudinal study of concussion and prolonged participation in contact/collision sports that follows ~500 student-athletes annually (~875 total) within and across sports seasons. In a typical year up to 15% of student-athletes are diagnosed with a concussion by a sports medicine physician. This provides a potent opportunity to investigate the impact of concussion on auditory processing in both the short-term (immediately after injury) and long-term (after a one- to four-year college athletic career). In the large group of non-concussed athletes, this project will establish whether, as hypothesized, auditory processing is more compromised over time in individuals participating in contact/collision sports. This project can elucidate the physiological mechanisms by which concussions and long-term participation in contact sports disrupt the central nervous system. The FFR will provide fine-grained insight into the nature of the physiological imprint of concussion. The longitudinal design in a large cohort provides powerful within- and between-subject controls for tracking head injuries and risk of injury based on sport in the short- and long-term stages, and opportunities for within-study replications. If successful, the FFR could one day serve as a fast, objective, and scalable clinical adjunct to assist in concussion diagnosis and management by indicating an individual's auditory processing profile following one or more concussions.

摘要 因为脑震荡的诊断标准依赖于自我报告-这在最近的一个研究中可能是不可靠的。 脑震荡的个人-这个项目的目标是确定一个脑震荡的神经标记，不需要 患者的努力。脑震荡对许多领域产生不利影响，有充分的理由相信， 初步数据支持，听觉系统的神经处理受到体育运动的负面影响- 与脑震荡有关通过使用听觉处理的客观电生理测量，这项工作 强大的潜力，以扩大理解脑震荡的影响感官处理，并消除一个 脑震荡的诊断和治疗中的主要陷阱。 这项提案使用了一种新的方法来了解头部受伤对感觉处理的影响： 对语音的频率跟随响应（FFR）。核心假设是， 听觉处理的测量作为中枢神经系统功能中断的标志， 脑震荡与西北大学体育学院合作，这是一项前瞻性的纵向研究， 脑震荡和长期参与接触/碰撞运动，每年约有500名学生运动员 （共875人）在运动季节内和运动季节之间。在一个典型的一年中，高达15%的学生运动员被诊断为 被运动医学医生诊断为脑震荡这提供了一个强有力的机会， 在短期（受伤后立即）和长期（受伤后 一至四年的大学体育生涯）。在非脑震荡运动员的大群体中，该项目将 确定是否如假设的那样，随着时间的推移，个体的听觉处理更容易受到损害 参加接触/碰撞运动。 这个项目可以阐明脑震荡和长期参与脑震荡的生理机制。 接触性运动会破坏中枢神经系统。FFR将提供对以下性质的细粒度洞察： 脑震荡的生理印记大型队列中的纵向设计提供了强大的内部和 受试者间控制，用于跟踪头部受伤情况以及基于短期和长期运动的受伤风险 阶段和研究内重复的机会。如果成功，FFR有一天可以作为一种快速， 客观的，可扩展的临床辅助工具，通过指示 一次或多次脑震荡后个体的听觉处理概况。

项目成果

Subconcussion revealed by sound processing in the brain.

• DOI: 10.1249/esm.0000000000000011
• 发表时间: 2023
• 期刊: Exercise, sport & movement

Non-stimulus-evoked activity as a measure of neural noise in the frequency-following response.

• DOI: 10.1016/j.jneumeth.2021.109290
• 发表时间: 2021-10-01
• 期刊: Journal of neuroscience methods
• 影响因子: 3
• 作者: Krizman J;Bonacina S;Otto-Meyer R;Kraus N
• 通讯作者: Kraus N

Athleticism and sex impact neural processing of sound.

• DOI: 10.1038/s41598-022-19216-2
• 发表时间: 2022-09-07
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Krizman, Jennifer;Bonacina, Silvia;Colegrove, Danielle;Otto-Meyer, Rembrandt;Nicol, Trent;Kraus, Nina
• 通讯作者: Kraus, Nina

Sex differences in auditory processing vary across estrous cycle.

• DOI: 10.1038/s41598-021-02272-5
• 发表时间: 2021-11-24
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Krizman J;Rotondo EK;Nicol T;Kraus N;Bieszczad KM
• 通讯作者: Bieszczad KM