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A preschool biomarker for literacy

学前识字生物标志物

基本信息

批准号：
9032506
负责人：
NINA KRAUS
金额：
$ 37.37万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2018-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9032506
关键词：
4 year old 8 year old Acoustics Affect Age Attention Auditory Auditory Brainstem Responses Biological Biological Markers Brain Stem Cerebral Dominance Child Code Cognitive Communication Data Development Developmental reading disorder Disease Dyslexia Early Intervention Early identification Electrodes Electrophysiology (science)Elements Employee Strikes Exhibits Failure Financial cost Future Genetic Transcription Goals Head Human Impairment Individual Instruction Intention Intervention Language Lead Learning Life Linguistics Link Literature Longitudinal Studies Machine Learning Measures Memory Modeling Nature Nervous system structure Neurologic Nursery Schools Outcome Pattern Physiological Physiological Processes Physiology Plant Roots Primary Schools Probability Process Publishing Reader Reading Reading Disorder Recording of previous events Research Research Personnel Resources Risk Role Scalp structure School-Age Population Schools Sensory Sensory Process Shapes Signal Transduction Speech Speech Sound Staging Stimulus Synapses Technology Testing Time Transcription Process Work abstracting age group auditory pathway base cognitive function cognitive skill cohort contextual factors corticofugal fiber experience falls intervention program literacy literate neurophysiology peer phonology reading ability reading difficulties relating to nervous system remediation response skills social sound spelling stimulus processing

项目摘要

DESCRIPTION (provided by applicant): As many as one in ten children have the poor reading and spelling skills that comprise developmental dyslexia. It is widely accepted that there is a neurological basis; however, the nature of that basis is hotly debated. Nevertheless, one consistent view is that poor phonological processing-the ability to access and manipulate the sound units of language-is involved in dyslexia. Indeed, a majority of children with reading deficits exhibit difficulties on an array of phonological processing tasks. A growing body of research has discovered that speech-sound transcription, as measured by electrophysiology, shows striking relationships with phonological processing skills and reading ability in school-age children. As such, we have developed a suite of subcortical and cortical physiological tests that probe some of the core deficits that researchers have postulated as the root elements of poor phonological processing. We will target the subcortical processing of time-varying signals and stimulus regularities, and cortical hemispheric specialization to both fast and slow signals. In a longitudinal cohort of four- to eight-year-olds, we will model the normal neurological speech transcription process, quantify its development, and examine its relationship with the development of literacy-related skills. Our intention is that by leveraging these electrophysiological probes to a pre-reading age group, a biomarker, in preschoolers, may be found that predicts a child's eventual reading skill as he/she progresses through the primary grades. If such a biomarker is found, it would pave the way for earlier and more effectively targeted intervention.

描述（由申请人提供）：多达十分之一的儿童阅读和拼写技能差，构成发展性阅读障碍。人们普遍认为存在神经学基础;然而，该基础的性质存在激烈争论。然而，一个一致的观点是，不良的语音处理能力，访问和操纵语言的声音单位，涉及阅读障碍。事实上，大多数有阅读缺陷的儿童在一系列语音处理任务上表现出困难。越来越多的研究发现，电生理学测量的语音转录与学龄儿童的语音处理技能和阅读能力有着显著的关系。因此，我们开发了一套皮层下和皮层生理测试，以探索研究人员假设为语音处理不良的根本因素的一些核心缺陷。我们将针对时变信号和刺激信号的皮层下处理，以及皮层半球对快信号和慢信号的专门化。在一个4 - 8奥尔兹的纵向队列中，我们将模拟正常的神经语音转录过程，量化其发展，并检查其与识字相关技能发展的关系。我们的目的是，通过利用这些电生理探针的前阅读年龄组，生物标志物，在学龄前儿童，可能会发现，预测一个孩子的最终阅读技能，他/她的进展，通过小学年级。如果发现这样的生物标志物，它将为更早和更有效的靶向干预铺平道路。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Auditory-neurophysiological responses to speech during early childhood: Effects of background noise.

DOI：
10.1016/j.heares.2015.06.009
发表时间：
2015-10
期刊：
Hearing research
影响因子：
2.8
作者：
White-Schwoch T;Davies EC;Thompson EC;Woodruff Carr K;Nicol T;Bradlow AR;Kraus N
通讯作者：
Kraus N

Sex differences in subcortical auditory processing only partially explain higher prevalence of language disorders in males.

DOI：
10.1016/j.heares.2020.108075
发表时间：
2020-12
期刊：
Hearing research
影响因子：
2.8
作者：
Krizman J;Bonacina S;Kraus N
通讯作者：
Kraus N

Hemispheric Asymmetry of Endogenous Neural Oscillations in Young Children: Implications for Hearing Speech In Noise.

幼儿内源性神经振荡的半球不对称：对噪声中听力言语的影响。

DOI：
10.1038/srep19737
发表时间：
2016
期刊：
Scientific reports
影响因子：
4.6
作者：
Thompson,ElaineC;WoodruffCarr,Kali;White-Schwoch,Travis;Tierney,Adam;Nicol,Trent;Kraus,Nina
通讯作者：
Kraus,Nina

Rhythm, reading, and sound processing in the brain in preschool children.