SPEECH EVOKED CORTICAL ERPS IN COCHLEAR IMPLANTS USERS

人工耳蜗使用者的言语诱发皮质 ERPS

• 批准号: 2443613
• 负责人: NINA KRAUS
• 金额: $ 25.35万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443613
• 关键词: auditory discrimination; auditory stimulus; behavior test; behavioral /social science research tag; cochlear implants; discrimination learning; evoked potentials; human subject; human therapy evaluation; longitudinal human study; psychoacoustics; sound frequency; speech recognition; speech synthesizers

DESCRIPTION: (Adapted From The Applicant's Abstract.) The degree of success and satisfaction experienced by cochlear-implant recipients varies greatly and is influenced significantly by the individual's ability to understand speech. It is hypothesized that the wide range of speech perception skills exhibited by cochlear-implant patients may be attributed, in part, to differences in central auditory processing abilities or in the capacity of the central auditory system to adapt to electrical stimulation. It is proposed to characterize speech-evoked cortical potentials in order to develop an objective measure of central auditory function in implant users. The long-term aim of this research is to develop a clinically feasible battery of speech--evoked electrophysiologic measures that can be used to evaluate the function of cochlear implants in deaf individuals. Optimally, that non-invasive test battery will be useful in assessing implant performance in patients who cannot undergo conventional behavioral testing (e.g. young children) and in providing a neurophysiologic basis for the design of rehabilitation programs and future implant signal-processing strategies. Specifically, the mismatch negativity (MMN)- a passively elicited evoked potential that reflects the cortical processing of fine acoustic stimulus differences - and the P300 cognitive potential will be investigated. Synthesized pairs of speech stimuli with well-defined acoustic parameters will be used to elicit the MMN and P300 in normal-hearing listeners and cochlear-implant patients to characterize the central neurophysiologic processes underlying normal and cochlear-implant-mediated speech perception. Those responses will be correlated with behavioral speech discrimination and related to clinical measures of speech perception and implant success. A subset of newly implanted adults and children will undergo the same battery of tests periodically for 12 months immediately after implantation to assess short-term longitudinal changes in electrophysiologic responses, auditory discrimination, and speech perception.

描述：（改编自申请人的摘要。）程度 人工耳蜗植入者的成功率和满意度 这是一个很大的影响，并受到个人的能力， 理解演讲。 据推测，广泛的言论， 耳蜗植入患者表现出的感知技能可以归因于， 部分原因是中枢听觉处理能力的差异， 中枢听觉系统适应电刺激的能力。 它提出了表征语音诱发皮层电位， 目的：建立一种客观评价人工耳蜗植入术后中枢听觉功能的方法 用户. 这项研究的长期目标是开发一种临床上 一套可行的言语诱发电生理测量方法， 用于评估耳聋患者人工耳蜗植入的功能。 最理想的情况是，非侵入性测试电池将有助于评估 无法接受常规行为治疗患者的植入物性能 测试（如幼儿），并提供神经生理学基础， 康复计划的设计和未来的植入信号处理 战略布局 具体地说，失配负性（MMN）-一种被动诱发的 反映精细声刺激的皮层处理的电位 差异-和P300认知潜力将被调查。 具有明确声学参数的合成语音刺激对 将被用来引出正常听力的听众的MMN和P300， 人工耳蜗植入患者的中枢神经生理特征 正常和耳蜗植入介导言语的基础过程 perception. 这些反应将与行为语言相关联 与言语感知的临床测量相关， 植入成功。 一部分新植入的成人和儿童将 立即定期接受一系列测试，为期12个月 植入后评估短期纵向变化， 电生理反应、听觉辨别和言语 perception.