A preschool biomarker for literacy

学前识字生物标志物

• 批准号: 8433336
• 负责人: NINA KRAUS
• 金额: $ 37.91万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433336
• 关键词: 4 year old; 8 year old; Acoustics; Affect; Age; Attention; Auditory; Auditory Brainstem Responses; Biological; Biological Markers; Brain Stem; Cerebral Dominance; Child; Code; Cognitive; Communication; Data; Development; Developmental reading disorder; Disease; Dyslexia; Early Intervention; Early identification; Electrodes; Electrophysiology (science); Elements; Employee Strikes; Exhibits; Failure; Financial cost; Future; Genetic Transcription; Goals; Head; Human; Impairment; Individual; Instruction; Intention; Intervention; Language; Lead; Learning; Life; Linguistics; Link; Literature; Longitudinal Studies; Machine Learning; Measures; Memory; Modeling; Nature; Nervous system structure; Neurologic; Nursery Schools; Outcome; Pattern; Physiological; Physiological Processes; Physiology; Plant Roots; Primary Schools; Probability; Process; Publishing; Reader; Reading; Reading Disorder; Recording of previous events; Relative (related person); Research; Research Personnel; Resources; Risk; Role; Scalp structure; School-Age Population; Schools; Sensory; Sensory Process; Shapes; Signal Transduction; Speech; Speech Sound; Staging; Stimulus; Synapses; Technology; Testing; Time; Transcription Process; Work; abstracting; age group; auditory pathway; base; cognitive function; cohort; contextual factors; corticofugal fiber; experience; falls; intervention program; literacy; literate; neurophysiology; peer; phonology; relating to nervous system; remediation; response; skills; social; sound; spelling; stimulus processing

DESCRIPTION (provided by applicant): As many as one in ten children have the poor reading and spelling skills that comprise developmental dyslexia. It is widely accepted that there is a neurological basis; however, the nature of that basis is hotly debated. Nevertheless, one consistent view is that poor phonological processing-the ability to access and manipulate the sound units of language-is involved in dyslexia. Indeed, a majority of children with reading deficits exhibit difficulties on an array of phonological processing tasks. A growing body of research has discovered that speech-sound transcription, as measured by electrophysiology, shows striking relationships with phonological processing skills and reading ability in school-age children. As such, we have developed a suite of subcortical and cortical physiological tests that probe some of the core deficits that researchers have postulated as the root elements of poor phonological processing. We will target the subcortical processing of time-varying signals and stimulus regularities, and cortical hemispheric specialization to both fast and slow signals. In a longitudinal cohort of four- to eight-year-olds, we will model the normal neurological speech transcription process, quantify its development, and examine its relationship with the development of literacy-related skills. Our intention is that by leveraging these electrophysiological probes to a pre-reading age group, a biomarker, in preschoolers, may be found that predicts a child's eventual reading skill as he/she progresses through the primary grades. If such a biomarker is found, it would pave the way for earlier and more effectively targeted intervention.

描述（由申请人提供）：多达十分之一的儿童阅读和拼写能力较差，构成发展性阅读障碍。人们普遍认为这是有神经学基础的；然而，这一基础的性质引起了激烈的争论。然而，一种一致的观点是，语音处理能力差——获取和操纵语言声音单位的能力——与阅读障碍有关。事实上，大多数有阅读缺陷的儿童在一系列语音处理任务上都表现出困难。越来越多的研究发现，通过电生理学测量的语音转录与学龄儿童的语音处理技能和阅读能力有着显着的关系。因此，我们开发了一套皮层下和皮层生理测试，以探究研究人员假设的一些核心缺陷，这些缺陷是语音处理不良的根源。我们的目标是皮层下对时变信号和刺激规律的处理，以及皮层半球对快速和慢速信号的专门化。在一个由四到八岁儿童组成的纵向队列中，我们将模拟正常的神经语音转录过程，量化其发展，并检查其与读写相关技能发展的关系。我们的目的是，通过将这些电生理学探针应用于阅读前年龄组，可以在学龄前儿童中发现一种生物标记，可以预测孩子在小学阶段的最终阅读技能。如果找到这样的生物标志物，将为更早、更有效的有针对性的干预铺平道路。