SPEECH EVOKED CORTICAL ERPS IN COCHLEAR IMPLANTS USERS

描述：(改编自申请人的摘要。)的程度 人工耳蜗植入者的成功和满意度各不相同 很大程度上受个人能力的影响 能听懂语言。据推测，人们讲话的范围很广 人工耳蜗植入患者表现出的感知技能可能是， 在一定程度上，是由于中枢听觉处理能力的差异或 中枢听觉系统对电刺激的适应能力。 提出了一种对语音诱发皮层电位进行有序表征的方法 建立种植体中枢听觉功能的客观测量方法 用户。这项研究的长期目标是开发一种临床上的 可行的语音电池--可诱发的电生理措施 用于评估聋人人工耳蜗术后的功能。 最好，非侵入性测试电池将用于评估 不能接受常规行为的患者的植入性能 测试(例如幼儿)并为以下各项提供神经生理学基础 康复方案的设计和未来植入物的信号处理 战略。 具体地说，失配负波(MMN)-被动诱发的诱发 反映细微声刺激的大脑皮层处理的电位 差异-以及P300的认知潜力将被调查。 具有明确定义的声学参数的合成语音刺激对 将被用来在听力正常的听者中诱发MMN和P300 人工耳蜗术患者中枢神经生理学特征的研究 正常语言和人工耳蜗语的潜在加工过程 感知力。这些反应将与行为言语相关联 言语知觉与临床测量的辨别力和相关性 植入成功。一组新植入的成人和儿童将 立即在12个月内定期进行相同的测试 以评估植入后的短期纵向变化。 电生理反应、听觉辨别和言语 感知力。

DESCRIPTION: (Adapted From The Applicant's Abstract.) The degree of success and satisfaction experienced by cochlear-implant recipients varies greatly and is influenced significantly by the individual's ability to understand speech. It is hypothesized that the wide range of speech perception skills exhibited by cochlear-implant patients may be attributed, in part, to differences in central auditory processing abilities or in the capacity of the central auditory system to adapt to electrical stimulation. It is proposed to characterize speech-evoked cortical potentials in order to develop an objective measure of central auditory function in implant users. The long-term aim of this research is to develop a clinically feasible battery of speech--evoked electrophysiologic measures that can be used to evaluate the function of cochlear implants in deaf individuals. Optimally, that non-invasive test battery will be useful in assessing implant performance in patients who cannot undergo conventional behavioral testing (e.g. young children) and in providing a neurophysiologic basis for the design of rehabilitation programs and future implant signal-processing strategies. Specifically, the mismatch negativity (MMN)- a passively elicited evoked potential that reflects the cortical processing of fine acoustic stimulus differences - and the P300 cognitive potential will be investigated. Synthesized pairs of speech stimuli with well-defined acoustic parameters will be used to elicit the MMN and P300 in normal-hearing listeners and cochlear-implant patients to characterize the central neurophysiologic processes underlying normal and cochlear-implant-mediated speech perception. Those responses will be correlated with behavioral speech discrimination and related to clinical measures of speech perception and implant success. A subset of newly implanted adults and children will undergo the same battery of tests periodically for 12 months immediately after implantation to assess short-term longitudinal changes in electrophysiologic responses, auditory discrimination, and speech perception.