Johns Hopkins Alzheimer's Disease Research Center

总体-项目总结/摘要 约翰霍普金斯阿尔茨海默病研究中心（JHADRC）是一个综合性的研究项目， 其总体目标是提高对AD早期阶段的理解， 接近。JHADRC的总体科学重点是AD和相关疾病的最早阶段 人类和模型系统，通过表征最早的临床和病理生理过程， 并通过识别导致模型系统异常的细胞和分子事件， 捕捉人类疾病的方方面面。我们还致力于改善患者的护理 疾病的症状阶段。我们在这些研究目标方面取得了实质性进展， 目前的资金周期，由P50中心赠款支持，并建议继续和扩大这项工作， 下一个融资周期，通过P30赠款机制。拟建中心由6个核心和1个 组成部分：（1）管理核心（核心A），（2）临床核心（核心B），（3）数据管理和 生物统计学核心（核心C），（4）神经病理学核心（核心D），（5）外展，招募和 参与核心（核心E），（6）生物标志物核心（核心F）和（7）研究教育组成部分 （REC）。在这个应用程序中，我们还包括3个发展项目的资金;我们预计资助一个 发展项目2年，两个发展项目各3年。

OVERALL – PROJECT SUMMARY/ ABSTRACT The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle, supported by a P50 center grant, and propose to continue and expand this work in the next funding cycle, through a P30 grant mechanism. The proposed Center consists of 6 Cores and one component : (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Biostatistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Biomarker Core (Core F) and (7) the Research Education Component (REC). In this application we are also including funds for 3 Developmental Projects; we anticipate funding one developmental project for 2 years and two developmental projects for 3 years each.