Johns Hopkins Alzheimer's Disease Research Center

总体而言——项目概要/摘要 约翰·霍普金斯大学阿尔茨海默病研究中心 (JHADRC) 是一个由研究人员组成的综合项目 其总体目标是提高对 AD 早期阶段的了解并扩大治疗范围 接近。 JHADRC 的总体科学重点是 AD 和相关疾病的最早阶段 人类和模型系统中，通过表征最早的临床和病理生理过程， 并通过识别导致模型系统异常的细胞和分子事件 捕捉人类疾病的各个方面。我们还致力于改善患者的护理 疾病的症状阶段。在此期间，我们在这些研究目标方面取得了实质性进展 目前的资助周期，由 P50 中心拨款支持，并建议在 下一个资助周期，通过 P30 赠款机制。拟议的中心由 6 个核心和 1 个组成 组成部分：(1) 管理核心（核心 A）、(2) 临床核心（核心 B）、(3) 数据管理和 生物统计学核心（核心 C）、(4) 神经病理学核心（核心 D）、(5) 外展、招募和 参与核心（核心 E）、(6) 生物标记核心（核心 F）和 (7) 研究教育部分 （记录）。在此申请中，我们还包括 3 个开发项目的资金；我们预计资助其中一项 为期 2 年的发展项目和两个为期 3 年的发展项目。

OVERALL – PROJECT SUMMARY/ ABSTRACT The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle, supported by a P50 center grant, and propose to continue and expand this work in the next funding cycle, through a P30 grant mechanism. The proposed Center consists of 6 Cores and one component : (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Biostatistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Biomarker Core (Core F) and (7) the Research Education Component (REC). In this application we are also including funds for 3 Developmental Projects; we anticipate funding one developmental project for 2 years and two developmental projects for 3 years each.