Johns Hopkins Alzheimer's Disease Research Center

总体--项目摘要/摘要 约翰霍普金斯阿尔茨海默病研究中心(JHADRC)是一个由研究人员组成的综合项目 其首要目标是提高对阿尔茨海默病早期阶段的了解并扩大治疗 接近了。JHADRC的总体科学重点是阿尔茨海默病和相关疾病的早期阶段 在人类和模型系统中，通过描述最早的临床和病理生理过程， 并通过识别导致模型系统中异常的细胞和分子事件 捕捉人类疾病的各个方面。我们还致力于改善医院病人的护理。 疾病的症状阶段。我们在这些研究目标方面取得了实质性进展。 目前的供资周期，由P50中心赠款支持，并提议继续并扩大这项工作在 下一个供资周期，通过P30赠款机制。拟议的中心由6个核心和1个核心组成 组成：(1)行政核心(核心A)，(2)临床核心(核心B)，(3)数据管理和 生物统计学核心(核心C)，(4)神经病理学核心(核心D)，(5)外联、招募和 参与核心(核心E)、(6)生物标记核心(核心F)和(7)研究教育部分 (记录)。在这份申请中，我们还包括了3个开发项目的资金；我们预计将资助一个项目 开发项目2年，开发项目2个，各3年。

OVERALL – PROJECT SUMMARY/ ABSTRACT The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle, supported by a P50 center grant, and propose to continue and expand this work in the next funding cycle, through a P30 grant mechanism. The proposed Center consists of 6 Cores and one component : (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Biostatistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Biomarker Core (Core F) and (7) the Research Education Component (REC). In this application we are also including funds for 3 Developmental Projects; we anticipate funding one developmental project for 2 years and two developmental projects for 3 years each.