Johns Hopkins Alzheimer's Disease Research Center

约翰霍普金斯大学阿尔茨海默病研究中心

• 批准号: 9921614
• 负责人: MARILYN S. ALBERT
• 金额: $ 315.41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9921614
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Baltimore; Basic Science; Behavioral; Biological Markers; Biological Models; Biostatistics Core; Cancer Education Grant Program; Cancer Grant Supplements (P30); Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Data; Data Analyses; Development; Disease; Enrollment; Environment; Event; Fostering; Funding; Funding Agency; Future; Goals; Grant; Growth; Human; Individual; Institution; Intramural Research Program; Joints; K-Series Research Career Programs; Laboratories; Leadership; Link; Longitudinal Studies; Mentorship; Methodology; Methods; Mind; Molecular; National Institute on Aging; Neurosciences; Participant; Patient Care; Patients; Phase; Pilot Projects; Play; Process; Research; Research Personnel; Research Training; Resources; Role; Source; Strategic Planning; Talents; Therapeutic; Tissue Banks; Tissues; Training; Training Support; Translating; Universities; Work; brain tissue; data management; design; education research; educational atmosphere; human model; improved; innovation; insight; interest; meetings; neuropathology; next generation; outreach; pre-clinical; programs; recruit; research study; senior faculty

OVERALL – PROJECT SUMMARY/ ABSTRACT The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle, supported by a P50 center grant, and propose to continue and expand this work in the next funding cycle, through a P30 grant mechanism. The proposed Center consists of 6 Cores and one component : (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Biostatistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Biomarker Core (Core F) and (7) the Research Education Component (REC). In this application we are also including funds for 3 Developmental Projects; we anticipate funding one developmental project for 2 years and two developmental projects for 3 years each.

总体-项目摘要/摘要