Core A: Administrative Core

行政核心-核心A：摘要 BIOCARD研究是一项纵向的观察性研究，对349名认知正常和 注册时主要为中年(平均年龄为57.1岁)。我们的总体目标是进一步推进 临床前AD的研究：(1)明确AD生物标志物(包括脑脊液、 核磁共振、淀粉样蛋白成像和血液)和认知，(2)最大限度地提高我们的 通过与具有可比较数据的几个研究小组协作，以及(3)提供 可公开访问的数据库，包括生物标本，供该领域的研究人员使用。要实现这些目标 目标我们建立了7个核心。行政核心(核心A)对总体运作和 协调项目。具体目标包括：(1)监督和整合项目中的核心， (2)促进与约翰·霍普金斯大学(JHU)以外的研究人员进行合作研究，(3) 保证健全的财政管理，(4)保证项目的所有方面都符合当地和 联邦条例，(5)通过科学咨询会议协调项目的外部审查 董事会和资源分配委员会，以及(6)与国家研究所的工作人员就 老化(NIA)符合FOA的指导方针。

ADMINISTRATIVE CORE - CORE A: ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. Our overall objectives are to further advance the study of preclinical AD by: (1) clarifying the pattern and rate of changes in AD biomarkers (including CSF, MRI, amyloid imaging and blood) and cognition that occur during the earliest phases of AD, (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible database, to include biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores. The Administrative Core (Core A) is essential for the overall functioning and coordination of the project. The specific aims include: (1) oversight and integration of the Cores in the project, (2) facilitation of collaborative research with investigators outside of Johns Hopkins University (JHU), (3) assurance of sound fiscal management, (4) assurance that all aspects of the project comply with local and federal regulations, (5) coordinating external review of the project through meetings of the Scientific Advisory Board and the Resource Allocation Committee, and (6) communicating with the staff of the National Institute on Aging (NIA) consistent with the guidelines of the FOA.