Reassessing FASD: Novel Approaches for Evaluating Exposure, Diagnosis and Outcomes in Children Prenatally Exposed to Alcohol
重新评估 FASD:评估产前接触酒精儿童的暴露、诊断和结果的新方法
基本信息
- 批准号:10376367
- 负责人:
- 金额:$ 48.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAffectAlcohol consumptionAlcoholsBehaviorBehavioralBody SizeCaregiversCategoriesCharacteristicsChildChildhoodClassificationClinicalCluster AnalysisCodeCognitionCognitiveCollaborationsCommunitiesCross-Sectional StudiesDataData AnalysesData SetDiagnosisDiagnosticDigit structureDysmorphologyEarly DiagnosisEarly identificationEducationEtiologyFaceFetal Alcohol ExposureFetal Alcohol Spectrum DisorderFoundationsFunctional disorderFundingFutureGeneral PopulationGrowthHealthHouseholdImageIncomeIndividualInterventionInterviewKnowledgeLeadLifeManuscriptsMeasurementMeasuresMediatingMediator of activation proteinMental HealthMethodologyMethodsMinorMissionModelingMothersNational Institute of Mental HealthNational Institute on Alcohol Abuse and AlcoholismNeurodevelopmental DeficitOutcomePatternPerformancePersonsPharmaceutical PreparationsPopulationPovertyPredictive ValuePregnancyPregnancy ComplicationsPregnancy HistoriesPreparationPrevalencePreventionProtocols documentationPublishingResearchResearch DesignResearch PersonnelResearch PriorityResearch ProposalsRiskRuralSamplingSchool-Age PopulationSiteTestingTimeUnited States National Institutes of HealthWorkalcohol consumption during pregnancyalcohol exposurearchive dataarchived databasecohesioncontextual factorscostdemographicsdevelopmental diseasediagnostic criteriadisabilitydisease classificationexperiencefetalfetal diagnosisfirst gradeimpaired brain developmentimprovedinnovationinsightmalformationmultidisciplinaryneurodevelopmentnovelnovel strategiesoffspringpopulation basedpostnatalprenatal exposureresiliencescreeningsecondary analysissexteacherurban residenceurban setting
项目摘要
Project Summary
Fetal alcohol spectrum disorders (FASD) are caused by prenatal alcohol exposure (PAE), and occur in 1-5% of
the population at a cost that exceeds $4 billion dollars per year. FASD is a continuum of developmental disorders,
and can result in life long disabilities. Although beneficial treatments exist, identification of affected individuals
has proven difficult, and the majority of individuals with FASD are undiagnosed or misdiagnosed. There are a
large number of gaps in knowledge that are critical to improvement in prevention, diagnosis and treatment for
FASD. First, although PAE is the cause of FASD, it is not deterministic. A better understanding of the specific
alcohol use patterns associated with specific FASD outcomes would inform prevention and intervention efforts,
and support earlier diagnoses. Second, classification schema that most effectively utilizes the many physical
signs associated with PAE and their contribution as markers of impaired brain development could lead to earlier
and better diagnosis. Third, although several co-factors have been established as modifiers of risk for FASD,
many more co-factors, mediators and modifiers remain unexplored that could substantially inform the
pathophysiology and intervention efforts. Each of these knowledge gaps represent high research priorities for
the prevention and treatment of FASD.
The purpose of this study is to improve diagnosis of FASD through research that specifically addresses these
aforementioned gaps. In a study previously funded by NIH-NIAAA, investigators formed The Collaboration on
Fetal Alcohol Spectrum Disorders Prevalence consortium (CoFASP) to determine, for first time, a regionally-
based prevalence estimate of FASD in four communities in the U.S. Together, these researchers developed a
common protocol for the cross-sectional study design and established agreed upon classification criteria for
FASD. Over 6,000 children were screened for FASD, and comprehensive data were collected on over 2,900
children for each of the relevant domains including dysmorphology; growth; cognitive, behavioral and adaptive
functioning; maternal characteristics; PAE and for a subset 3D facial images. Using the CoFASP data set, we
will 1) employ novel methods to elucidate exposure patterns associated with risk for PAE-related outcomes, 2)
test new methodologies and diagnostic criteria as they pertain to FASD diagnosis and neurodevelopmental
outcomes, and 3) investigate contextual and health-related covariates that function as mediators and/or modifiers
of FASD.
The advances proposed in this research allow for insights into the etiology and classification of FASD, and
ultimately, factors that affect the prevalence of FASD. The investigators on this proposal are multidisciplinary,
and together offer an innovative and cohesive approach to the research proposal. Through these novel
approaches, we anticipate providing a foundation for future classification schema, exposure assessment and
intervention strategies that are grounded in empirical evidence.
项目摘要
胎儿酒精谱系障碍(FASD)是由产前酒精暴露(PAE)引起的,
每年花费超过40亿美元。FASD是一系列发育障碍,
并可能导致终身残疾。虽然存在有益的治疗方法,但受影响个体的识别
已被证明是困难的,大多数患有FASD的个体未被诊断或误诊。有
在知识方面存在大量空白,而这些空白对改善预防、诊断和治疗
FASD。首先,虽然PAE是FASD的原因,但它不是确定性的。更好地了解具体的
与特定FASD结果相关的酒精使用模式将为预防和干预工作提供信息,
并支持早期诊断。第二,分类模式,最有效地利用了许多物理
与PAE相关的体征及其作为大脑发育受损标志物的作用可能导致早期
更好的诊断。第三,尽管已经确定了几个辅助因素作为FASD风险的修饰因子,
还有更多的辅助因子、介导因子和修饰因子尚未被探索,这些因素可能会在很大程度上影响
病理生理学和干预措施。这些知识差距中的每一个都代表着高度的研究优先事项,
FASD的预防和治疗。
本研究的目的是通过专门针对这些问题的研究来改善FASD的诊断。
上述差距。在先前由NIH-NIAAA资助的一项研究中,研究人员组成了
胎儿酒精谱系障碍患病率联盟(CoFASP)首次确定了一个区域性的
基于美国四个社区的FASD患病率估计,这些研究人员共同开发了一个
横断面研究设计的通用方案,并建立了一致同意的分类标准,
FASD。对6,000多名儿童进行了FASD筛查,并收集了2,900多名儿童的综合数据。
每个相关领域的儿童,包括畸形;生长;认知,行为和适应
功能;母体特征; PAE和用于子集3D面部图像。使用CoFASP数据集,我们
将1)采用新方法阐明与PAE相关结局风险相关的暴露模式,2)
测试与FASD诊断和神经发育相关的新方法和诊断标准
结果,以及3)调查作为中介和/或修饰符的背景和健康相关协变量
的FASD。
本研究提出的进展允许深入了解FASD的病因和分类,
最终,影响FASD患病率的因素。这项提案的调查人员是多学科的,
并共同为研究提案提供创新和有凝聚力的方法。通过这些小说
方法,我们预计提供了一个基础,为未来的分类模式,暴露评估,
基于经验证据的干预策略。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.
- DOI:10.1016/j.drugalcdep.2022.109351
- 发表时间:2022-04-01
- 期刊:
- 影响因子:4.2
- 作者:Bandoli, G.;Kable, J. A.;Coles, C. D.;Del Campo, M.;Suttie, M.;Chambers, C. D.
- 通讯作者:Chambers, C. D.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gretchen E. Bandoli其他文献
Gretchen E. Bandoli的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gretchen E. Bandoli', 18)}}的其他基金
14/24 The Healthy Brain & Child Development National Consortium
14/24 健康的大脑
- 批准号:
10378364 - 财政年份:2021
- 资助金额:
$ 48.81万 - 项目类别:
14/24 The Healthy Brain & Child Development National Consortium
14/24 健康的大脑
- 批准号:
10661766 - 财政年份:2021
- 资助金额:
$ 48.81万 - 项目类别:
14/24 The Healthy Brain & Child Development National Consortium
14/24 健康的大脑
- 批准号:
10757271 - 财政年份:2021
- 资助金额:
$ 48.81万 - 项目类别:
14/24 The Healthy Brain & Child Development National Consortium
14/24 健康的大脑
- 批准号:
10494150 - 财政年份:2021
- 资助金额:
$ 48.81万 - 项目类别:
Reassessing FASD: Novel Approaches for Evaluating Exposure, Diagnosis and Outcomes in Children Prenatally Exposed to Alcohol
重新评估 FASD:评估产前接触酒精儿童的暴露、诊断和结果的新方法
- 批准号:
10204862 - 财政年份:2020
- 资助金额:
$ 48.81万 - 项目类别:
Applying Machine Learning in the Prediction and Identification of Children Affected by Prenatal Alcohol Exposure
应用机器学习来预测和识别受产前酒精暴露影响的儿童
- 批准号:
10475144 - 财政年份:2019
- 资助金额:
$ 48.81万 - 项目类别:
Applying Machine Learning in the Prediction and Identification of Children Affected by Prenatal Alcohol Exposure
应用机器学习来预测和识别受产前酒精暴露影响的儿童
- 批准号:
10245104 - 财政年份:2019
- 资助金额:
$ 48.81万 - 项目类别:
Applying Machine Learning in the Prediction and Identification of Children Affected by Prenatal Alcohol Exposure
应用机器学习来预测和识别受产前酒精暴露影响的儿童
- 批准号:
10018803 - 财政年份:2019
- 资助金额:
$ 48.81万 - 项目类别:
Applying Machine Learning in the Prediction and Identification of Children Affected by Prenatal Alcohol Exposure
应用机器学习来预测和识别受产前酒精暴露影响的儿童
- 批准号:
9805491 - 财政年份:2019
- 资助金额:
$ 48.81万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 48.81万 - 项目类别:
Research Grant