14/24 The Healthy Brain & Child Development National Consortium

14/24 健康的大脑

• 批准号: 10494150
• 负责人: Gretchen E. Bandoli
• 金额: $ 72.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494150
• 关键词: 10 year old; Address; Adverse event; Affect; Alcohols; Behavioral; Biological; Birth; Brain; COVID-19; Caregivers; Child; Child Development; Communities; Complement; Conceptions; DNA; Data; Data Collection; Data Coordinating Center; Data Set; Development; Enrollment; Environment; Environmental Exposure; Environmental Hazards; Epigenetic Process; Ethics; Event; Exposure to; Feedback; General Population; Genes; Goals; Health; Helping to End Addiction Long-term; Human; Infant; Infection; Life; Link; Location; Malnutrition; Marijuana; Maternal Health; Measures; Methods; Modality; Monitor; Mothers; Newborn Infant; Opiate Addiction; Opioid; Outcome; Participant; Persons; Physiological; Population; Pregnancy; Pregnant Women; Process; Protocols documentation; Psychopathology; Public Health; Public Policy; Research; Research Design; Research Personnel; Sampling; Second Pregnancy Trimester; Severities; Shapes; Site; Speed; Stress; Structural Racism; Time; Time Study; Tobacco; Toxicant exposure; Training; United States; United States National Institutes of Health; Woman; Work; base; caregiving; child bearing; cohort; critical period; data harmonization; data integrity; data standards; design; early experience; early life exposure; experience; hazard; high dimensionality; improved; innovation; insight; magnetic resonance imaging/electroencephalography; maltreatment; maternal stress; multimodality; neurodevelopment; neuroimaging; novel; opioid misuse; postnatal; pregnant; prenatal; protective factors; psychologic; racial and ethnic; recruit; remote assessment; socioeconomics; sound; stem; substance use; tool

Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant women with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state- of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.

神经发育过程是由基因和环境之间的动态相互作用形成的。 生命早期的适应不良经历可以改变发展轨迹，导致有害和持久的 发育后遗症产前和产后危害包括母体物质暴露、有毒物质暴露 在怀孕和生命早期，母亲的健康状况，父母的精神病理学，虐待，结构 种族歧视和过度压力为了阐明各种环境危害如何影响儿童发展， 必须建立生命头10年发展轨迹的规范模板 基于足够大且人口统计学上多样化的美国人口样本。为了实现这一点， 健康大脑和儿童发展国家联盟（HBCD-NC）已经成立， 一套协调、优化和创新的神经成像（MRI、EEG）措施， 广泛的行为，生理和心理工具电池，和生物标本，以了解 在美国24个地点登记的7,500名母亲和婴儿的样本中， 美国。六溴环十二烷国家中心将在六溴环十二烷国家中心的指导下执行一项共同研究方案 行政核心（HCAC），并将收集和分发一个全面和精心策划的研究 在六溴环十二烷NC数据协调中心的指导下， （HDCC）。六溴环十二烷国家信息通报的总体目标是建立一个全面、协调和高水平的 三维数据集，将表征美国儿童的典型神经发育轨迹， 评估生物和环境暴露如何影响这些轨迹。将特别强调 了解产前和产后接触阿片类药物、大麻、酒精、烟草和/或其他 物质.为了实现这些广泛的目标，登记的妇女样本将包括：1）种族， 代表美国人口的种族和社会经济多样化队列; 2）孕妇 使用目标物质（阿片类药物，大麻，酒精，烟草）; 3）人口统计学和行为学 类似的妇女在怀孕期间没有使用药物，使有效的因果关系推断。此外，六溴环十二烷NC 将确定关键的发展窗口，在此期间，有害和保护性环境的影响最大， 对以后神经发育结果的影响。大型、多模态、纵向和可推广的数据集 这将是首次由这项研究将提供新的见解儿童发展使用状态- 最先进的方法。六溴环十二烷-NC研究将为公共政策提供信息， 全国各地的孩子。