Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 10381506
• 负责人: JERRY A STITZEL
• 金额: $ 34.7万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381506
• 关键词: Genetic; Research Training; Substance abuse problem

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on substance abuse. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 50 years. Major substance abuse-related research projects are in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the NIDA Genetics Consortium, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of SNPs robustly associated with drug phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 3 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.

项目摘要 该提案寻求通过机构培训赠款继续支持一项学前和学前教育培训方案， 博士后研究员，他们将从事专注于药物滥用遗传影响的研究事业。 来自行为遗传学研究所（IBG）和合作单位的教师是杰出和活跃的 在研究中，IBG的科学家们积极研究遗传对药物滥用的影响， 超过50年在人类和动物中进行的与药物滥用有关的主要研究项目正在进行中 行为遗传学生物统计、统计和定量遗传技术的应用， 生物信息学、全基因组分析和下一代测序，以及表观遗传学，正在提供真实的 知识的进步。神经化学、药理学、生理学和分子遗传学研究， 提供了对与行为相关的基因功能的理解。自上次申请以来，我们增加了一个 主要致力于功能和结构脑成像作为研究工具，并扩大了我们的教师队伍 相应的培训计划。我们的研究和培训包括使用大规模的合作研究 他们正在积累DNA储存库和丰富的表型数据集，可用于药物滥用的研究。 其中包括青少年大脑认知发展（ABCD）研究，我们的培训教师是 双胞胎研究组成部分的PI，NIDA遗传学联盟，精神病遗传学联盟，英国 生物银行和GSCAN，一项超过100万病例的全基因组研究。IBG设施可用于基因 功能和表达研究，以及行为，生物化学和神经生理学研究，我们正在 积极开展与药物密切相关的SNP的功能意义的动物模型研究， 在人类群体中的表型。反映培训需求的扩大，特别是遗传学方面的培训需求 在ABCD背景下应用的专业知识，脑成像，转化研究和“大数据”研究，基金 要求支持6名博士前和3名博士后学员。学员通常会得到支持， 到3年。博士预科学员从合作学术单位获得博士学位和证书 在行为遗传学上。培训计划的学术要求包括行为遗传学培训， 定量和生物统计遗传学，理论和计算机统计学，分子遗传学， 神经科学，生物信息学和基因组学，负责任地进行研究的强制性培训，以及 行为、脑成像和临床表型课程。附加要求根据 学位授予学术单位研究是培训的一个组成部分。博士后学员也追求一个 一个正式的计划，强调个人的研究以及在分子和定量能力 行为遗传学为药物滥用研究职业做准备的其他活动包括： 学生和/或技术人员，主持研讨会发言人和会议组织，客座演讲， 每周的期刊俱乐部，赠款写作，以及个人专业计划的发展。