Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 10618400
• 负责人: JERRY A STITZEL
• 金额: $ 36.05万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618400
• 关键词: Genetic; Research Training; Substance abuse problem

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on substance abuse. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 50 years. Major substance abuse-related research projects are in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the NIDA Genetics Consortium, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of SNPs robustly associated with drug phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 3 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.

项目总结

项目成果

Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area.

• DOI: 10.1007/s00213-014-3796-7
• 发表时间: 2015-05
• 期刊: PSYCHOPHARMACOLOGY
• 影响因子: 3.4
• 作者: Yap, Jasmine J.;Chartoff, Elena H.;Holly, Elizabeth N.;Potter, David N.;Carlezon, William A., Jr.;Miczek, Klaus A.
• 通讯作者: Miczek, Klaus A.

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.

• DOI: 10.1007/s10519-016-9792-4
• 发表时间: 2016-09
• 期刊: Behavior genetics
• 影响因子: 2.6
• 作者: Kamens HM;Corley RP;Richmond PA;Darlington TM;Dowell R;Hopfer CJ;Stallings MC;Hewitt JK;Brown SA;Ehringer MA
• 通讯作者: Ehringer MA

Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.

检查欧洲和非裔美国人尼古丁行为中胆碱能相关基因的参与情况。

• DOI: 10.1093/ntr/ntw200
• 发表时间: 2017
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Melroy-Greif,WhitneyE;Simonson,MatthewA;Corley,RobinP;Lutz,SharonM;Hokanson,JohnE;Ehringer,MarissaA
• 通讯作者: Ehringer,MarissaA

The genetic components of alcohol and nicotine co-addiction: from genes to behavior.

• DOI: 10.2174/1874473710801020124
• 发表时间: 2008-05
• 期刊: Current drug abuse reviews
• 作者: I. Schlaepfer;Nicole R. Hoft;M. Ehringer

Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels.

• DOI: 10.12688/f1000research.2-53.v1
• 发表时间: 2013
• 期刊: F1000Research
• 作者: Pomrenze MB;Baratta MV;Rasmus KC;Cadle BA;Nakamura S;Birnbaumer L;Cooper DC
• 通讯作者: Cooper DC