Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 10618400
• 负责人: JERRY A STITZEL
• 金额: $ 36.05万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618400
• 关键词: Genetic; Research Training; Substance abuse problem

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on substance abuse. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 50 years. Major substance abuse-related research projects are in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the NIDA Genetics Consortium, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of SNPs robustly associated with drug phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 3 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.

项目总结 这项提案寻求通过机构培训赠款继续支持预科和预科教育培训方案。 博士后研究员，他们将从事专注于基因对药物滥用影响的研究事业。 来自行为遗传学研究所(IBG)和合作单位的教员是杰出的和活跃的 在研究中，IBG的科学家们积极研究基因对药物滥用的影响 50多年了。与药物滥用有关的重大研究项目正在人类和动物身上进行 行为遗传学。生物测定、统计和数量遗传技术的应用，以及 生物信息学、全基因组分析和下一代测序，以及表观遗传学，正在提供真正的 知识的进步。神经化学、药理学、生理学和分子遗传学研究 提供与行为相关的基因功能的理解。自从我们的上一个应用程序以来，我们添加了一个 主要致力于将功能和结构脑成像作为研究工具，并扩大了我们的师资队伍 以及相应的培训计划。我们的研究和培训包括使用大规模合作研究 正在积累可用于药物滥用研究的DNA存储库和丰富的表型数据集。 其中包括青少年大脑认知发展(ABCD)研究，我们的培训人员正在进行这项研究 双胞胎研究组成部分NIDA遗传学联合会的PIS，精神病学遗传学联合会，英国 Biobank和GSCAN，这是一项对100多万例患者进行的全基因组研究。可为基因提供IBG设备 功能和表达研究，以及行为、生化和神经生理学研究，我们是 积极开展与药物相关的SNPs功能影响的动物模型研究 人类群体中的表型。以反映对培训，特别是对遗传学的更大需求 在ABCD、脑成像、翻译研究和大数据研究中应用的专业知识，基金 要求支持6名博士后和3名博士后实习生。受训人员通常将获得UP支持 到3年。博士前实习生从合作的学术单位获得博士学位并获得认证 在行为遗传学方面。培训计划的学术要求包括行为遗传学方面的培训， 定量和生物计量遗传学、理论和计算机统计学、分子遗传学、 神经科学、生物信息学和基因组学，负责任的研究行为方面的强制性培训，以及 关于行为、脑成像和临床表型的课程。附加要求根据 学位授予学术单位。研究是培训不可或缺的一部分。博士后实习生还将攻读 强调个人研究以及在分子和定量方面的能力的正式计划 行为遗传学。为药物滥用研究生涯做准备的其他活动包括：监督 学生和/或技术人员，主持研讨会演讲者和会议组织，客座演讲， 周刊俱乐部，拨款写作，以及个人职业计划的发展。

项目成果

Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area.

• DOI: 10.1007/s00213-014-3796-7
• 发表时间: 2015-05
• 期刊: PSYCHOPHARMACOLOGY
• 影响因子: 3.4
• 作者: Yap, Jasmine J.;Chartoff, Elena H.;Holly, Elizabeth N.;Potter, David N.;Carlezon, William A., Jr.;Miczek, Klaus A.
• 通讯作者: Miczek, Klaus A.

Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.

• DOI: 10.1007/s10519-016-9792-4
• 发表时间: 2016-09
• 期刊: Behavior genetics
• 影响因子: 2.6
• 作者: Kamens HM;Corley RP;Richmond PA;Darlington TM;Dowell R;Hopfer CJ;Stallings MC;Hewitt JK;Brown SA;Ehringer MA
• 通讯作者: Ehringer MA

Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans.

检查欧洲和非裔美国人尼古丁行为中胆碱能相关基因的参与情况。

• DOI: 10.1093/ntr/ntw200
• 发表时间: 2017
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Melroy-Greif,WhitneyE;Simonson,MatthewA;Corley,RobinP;Lutz,SharonM;Hokanson,JohnE;Ehringer,MarissaA
• 通讯作者: Ehringer,MarissaA

The genetic components of alcohol and nicotine co-addiction: from genes to behavior.

• DOI: 10.2174/1874473710801020124
• 发表时间: 2008-05
• 期刊: Current drug abuse reviews
• 作者: I. Schlaepfer;Nicole R. Hoft;M. Ehringer

Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels.

• DOI: 10.12688/f1000research.2-53.v1
• 发表时间: 2013
• 期刊: F1000Research
• 作者: Pomrenze MB;Baratta MV;Rasmus KC;Cadle BA;Nakamura S;Birnbaumer L;Cooper DC
• 通讯作者: Cooper DC