Research Training Fellowship in Substance Abuse

项目总结/摘要 这是T32培训计划的竞争性更新，即物质研究培训奖学金 虐待方案（RTFSA-P），自1988年以来一直存在。尽管最近的进展， 了解成瘾的神经生物学，在应用所获得的知识方面存在持续的差距 从基础科学研究到成瘾领域的临床实践。新一代的行为， 精神药理学、神经影像学、分子遗传学和分子神经科学研究具有广泛的应用前景。 临床意义和这些研究带来了潜在的桥梁之间的差距差距基础和临床研究。 尽管现有科学的质量，弥合这一差距的实际进展也取决于 提供经过适当培训的年轻科学家。RTFSA-P的目的是满足这一需求， 为总共4名对翻译或翻译职业感兴趣的医生或博士提供博士后培训。 成瘾领域的干预研究。拟议的RTFSA-P是该司的一个两年期方案 成瘾（DA），精神病学系，耶鲁大学医学院，并将提供博士后学员 在职业生涯的初始阶段，有机会投入几乎全部时间的努力， 成为临床或翻译领域的独立研究人员所需的技能和经验 物质使用障碍的研究DA是一个正在进行的，稳定的成瘾研究计划， 包括超过123个主要资助项目，包括4个涵盖广泛主题的中心， 研究方法。这有助于研究从临床前到临床研究的快速和双向发展 项目（“实验室”）到临床研究（“床边”和“社区”）。申请人将是MD或PhD博士后 接受过精神病学、内科学、临床心理学等专业培训的候选人， 神经科学候选人将由录取委员会根据他们的优秀潜力进行选择 在成瘾的转化或干预研究领域。RTFSA-P计划包括（1） 个性化的研究指导，（2）成功完成一个学术研究项目，（3）核心 课程，其中包括成瘾临床研究和治疗，生物统计学和研究研讨会 设计，科学研究的负责任的行为和赠款写作技能和（4）个性化的参与 在部门感兴趣的研讨会，医学院和大学。培训设施包括 耶鲁大学医学院附属主要机构精神病学系。结束时 培训，申请人将非常适合在翻译或干预研究的独立职业生涯， 成瘾领域。

Project Summary/Abstract This is the competitive renewal of a T32 training program, the Research Training Fellowship in Substance Abuse Program (RTFSA-P), which has been in existence since 1988. Despite recent advances in understanding the neurobiology of addiction, there is a persistent gap in the application of knowledge gained from basic science studies to clinical practice in the field of addiction. A new generation of behavioral, psychopharmacology, neuroimaging, molecular genetics and molecular neuroscience studies has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, actual progress in bridging this gap depends also upon the availability of appropriately trained young scientists. The purpose of the RTFSA-P is to meet this need by providing post-doctoral training for a total of 4 physicians or PhDs interested in careers in translational or intervention research in the field of addiction. The proposed RTFSA-P is a two-year program in the Division of Addictions (DA), Department of Psychiatry, Yale School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort, during the initial phase of their careers, to developing the skills and experience needed to become independent researchers in the field of clinical or translational research in substance use disorders. The DA is an ongoing, stable addiction research program that now encompasses over 123 major funded projects including 4 Centers covering a broad scope of topics and research methodologies. This facilitates research that moves rapidly and in both directions from preclinical projects (“bench”) to clinical studies (“bedside” and “community”). Applicants will be MDs or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology, or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational or intervention research in addictions. The RTFSA-P program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which includes seminars on addiction clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in the Department, Medical School and University. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational or intervention research in the field of addiction.