MULTIMODAL IMAGING OF NEUROHIV DYNAMICS (MIND): AN OMAHA-PITTSBURGH CONSORTIUM
神经艾滋病毒动力学(心智)的多模态成像:奥马哈-匹兹堡联盟
基本信息
- 批准号:10379337
- 负责人:
- 金额:$ 75.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AIDS dementiaAIDS/HIV problemAcquired Immunodeficiency SyndromeAdultAffectArchitectureAreaAttentionBehavioralBrainBrain MappingBrain regionChronicCodeCognition DisordersCognitiveCognitive ScienceCollectionComplicationCustomDataData AnalysesDatabasesDevelopmentDiseaseEconomicsElectrophysiology (science)EtiologyExhibitsFunctional Magnetic Resonance ImagingFunctional disorderGeneral PopulationGoalsHIVHIV InfectionsHIV-associated cognitive impairmentHIV-associated neurocognitive disorderHumanImageImpaired cognitionImpairmentIndividualKnowledgeLife ExpectancyLiteratureMagnetic Resonance ImagingMagnetoencephalographyMapsMeasuresMediator of activation proteinMedical HistoryMedical centerMemory impairmentMethodsModalityMonitorMotorMotor CortexMultimodal ImagingNational NeuroAids Tissue ConsortiumNatureNebraskaNeurobiologyNeurologicNeuronsNeuropsychological TestsParietal LobeParticipantPatientsPenetrationPerformancePersonsPhysiologicalPhysiologyPlayPrevalencePublishingQuality of lifeRequest for ApplicationsRequest for ProposalsResearchResearch Domain CriteriaResourcesRestRiskRoleSamplingShort-Term MemorySourceStructureTargeted ResearchTechniquesTerminal DiseaseThe Multicenter AIDS Cohort StudyThickTime Series AnalysisUnemploymentUniversitiesViralVisual PerceptionVisual attentionWestern WorldWorkantiretroviral therapycognitive controlcognitive functioncognitive systemcognitive taskcomorbiditygamma-Aminobutyric Acidhemodynamicsimaging approachimaging modalityimaging studyinnovationinstrumentationinterestlifestyle factorsmagnetic resonance spectroscopic imagingmedication compliancemotor disordermultimodal neuroimagingmultimodalityneural circuitneuroAIDSneuroimagingneuromechanismneuronal circuitrynovelreceptorrelating to nervous systemresponse
项目摘要
Project Summary/Abstract
HIV-infected adults in the western world have a life expectancy near that of the general population, but are at a
significantly elevated risk of developing cognitive impairments. Such impairments are the most common
neurological complication of HIV disease, with prevalence estimates ranging from 35-70% of all HIV-infected
individuals. Research targeting such comorbidities has been identified as a top priority by the Office of AIDS
Research (NOT-OD-15-137). While the mechanisms underlying these deficits are not well understood,
numerous human neuroimaging studies have examined the brain areas that may be involved, and overall these
studies have been largely successful in identifying the critical hubs and networks. However, many questions
remain regarding basic circuit dysfunction within these brain regions, and consequently there is a clear and
common need to further investigate the neural dynamics and connectivity, as well as other key physiological
parameters that may underlie the development and progression of HIV-related cognitive dysfunction.
This proposal responds to RFA-MH-18-610, which requests proposals that “advance knowledge of the etiology
of mild to moderate forms of HIV-related cognitive dysfunction by clarifying the role played by altered neuronal
circuits, receptors, and networks,” using “novel neuro-electrophysiological and neuroimaging techniques.” The
Multimodal Imaging of NeuroHIV Dynamics (MIND) Consortium responds to this call with an innovative, large-
scale multimodal neuroimaging study that uses the latest breakthroughs in instrumentation and data analyses
to identify the pathophysiology of neuroHIV in virally-suppressed adults. Specifically, the consortium will use
advanced magnetoencephalographic (MEG) imaging to quantify the region- and circuit-level neural dynamics
serving cognitive processing, 3-Tesla MRI and multimodal parcellation methods to map areal brain architecture,
functional MRI (fMRI) for hemodynamics and intrinsic networks, and 7-Tesla magnetic resonance spectroscopic
imaging (MRSI) to quantify GABA levels in multi-voxel slabs of interest identified by the functional modalities.
The investigative team includes a unique combination of experts in MEG, MRI/fMRI, MRSI, and cognitive
psychology from the University of Nebraska and University of Pittsburgh Medical Centers (UNMC/UPMC). In
addition, this consortium will harness existing resources such as the Multicenter AIDS Cohort Study (MACS)
database and the National NeuroAIDS Tissue Consortium (NNTC) and, consistent with the RFA, will follow the
Research Domain Criteria (RDoC) framework to define cognitive constructs. The consortium’s overarching
hypothesis is that HIV-infected adults will exhibit aberrations in local inhibitory circuits, and that these deficits
will alter gamma oscillations and thereby impair neuronal coding and interregional functional connectivity in the
theta range. Such gamma deficits would provide robust explanatory power for the breadth of pathophysiological
findings in the existent literature, and the MIND study is uniquely powered to investigate the underlying sources
of these deficits, which are likely multifactorial (e.g., medical history, lifestyle factors, CNS viral penetration).
项目总结/摘要
在西方世界,感染艾滋病毒的成年人的预期寿命接近一般人口,
认知障碍的风险显著增加。这种损伤是最常见的
艾滋病毒疾病的神经系统并发症,患病率估计占所有艾滋病毒感染者的35-70%
个体艾滋病办公室已将针对此类合并症的研究确定为最优先事项
研究(NOT-OD-15-137)。虽然这些缺陷背后的机制还不清楚,
许多人类神经成像研究已经检查了可能涉及的大脑区域,总体而言,
这些研究在确定关键枢纽和网络方面基本上取得了成功。然而,许多问题
仍然关于这些大脑区域内的基本电路功能障碍,因此有一个明确的,
共同需要进一步研究神经动力学和连接,以及其他关键的生理
这些参数可能是HIV相关认知功能障碍发展和进展的基础。
本提案响应了RFA-MH-18-610,该提案要求提出“促进病因学知识
轻度至中度形式的艾滋病毒相关的认知功能障碍,通过阐明改变的神经元所起的作用,
电路,受体和网络,“使用”新的神经电生理和神经成像技术。的
神经HIV动力学多模态成像(MIND)联盟响应这一呼吁,推出了一个创新的大型-
大规模多模式神经成像研究,使用仪器和数据分析的最新突破
以确定病毒抑制成人中神经HIV的病理生理学。具体而言,该财团将利用
先进的脑磁图(MEG)成像,以量化区域和回路水平的神经动力学
提供认知处理、3特斯拉MRI和多模式分割方法,以绘制区域大脑结构,
用于血流动力学和内在网络的功能性MRI(fMRI),以及7特斯拉磁共振光谱
磁共振成像(MRSI)来量化由功能模态识别的感兴趣的多体素板中的GABA水平。
调查团队包括MEG,MRI/fMRI,MRSI和认知方面的专家
内布拉斯加大学和匹兹堡大学医学中心(UNMC/UPMC)的心理学。在
此外,该联盟将利用现有资源,如多中心艾滋病队列研究(MACS)
数据库和国家神经艾滋病组织联盟(NNTC),并与RFA一致,将遵循
研究领域标准(RDoC)框架来定义认知结构。该联盟的首要任务是
一种假设是,HIV感染的成年人将在局部抑制回路中表现出畸变,这些缺陷
将改变伽马振荡,从而损害神经元编码和区域间功能连接,
θ范围这种伽马缺陷将为病理生理学的广度提供强有力的解释力。
现有文献中的发现,MIND研究是唯一能够调查潜在来源的研究。
这些缺陷,这可能是多因素的(例如,病史、生活方式因素、CNS病毒渗透)。
项目成果
期刊论文数量(78)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.
亚临床焦虑和创伤后应激会影响青春期皮质稀疏。
- DOI:10.1016/j.jaac.2020.11.020
- 发表时间:2021-10
- 期刊:
- 影响因子:13.3
- 作者:Taylor BK;Eastman JA;Frenzel MR;Embury CM;Wang YP;Stephen JM;Calhoun VD;Badura-Brack AS;Wilson TW
- 通讯作者:Wilson TW
Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.
- DOI:10.1016/j.neuroimage.2020.117048
- 发表时间:2020-10-15
- 期刊:
- 影响因子:5.7
- 作者:Spooner RK;Eastman JA;Wiesman AI;Wilson TW
- 通讯作者:Wilson TW
Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV.
- DOI:10.1002/hbm.25634
- 发表时间:2021-11
- 期刊:
- 影响因子:4.8
- 作者:Christopher-Hayes NJ;Lew BJ;Wiesman AI;Schantell M;O'Neill J;May PE;Swindells S;Wilson TW
- 通讯作者:Wilson TW
Multivariate patterns of brain-behavior associations across the adult lifespan.
- DOI:10.18632/aging.203815
- 发表时间:2022-01-10
- 期刊:
- 影响因子:0
- 作者:Doucet GE;Hamlin N;West A;Kruse JA;Moser DA;Wilson TW
- 通讯作者:Wilson TW
Resting-state functional connectivity of the human hippocampus in periadolescent children: Associations with age and memory performance.
- DOI:10.1002/hbm.25458
- 发表时间:2021-08-01
- 期刊:
- 影响因子:4.8
- 作者:Warren DE;Rangel AJ;Christopher-Hayes NJ;Eastman JA;Frenzel MR;Stephen JM;Calhoun VD;Wang YP;Wilson TW
- 通讯作者:Wilson TW
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Tony W Wilson其他文献
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{{ truncateString('Tony W Wilson', 18)}}的其他基金
Suppression of Pathological Spontaneous Cortical Dynamics and Inflammation in NeuroHIV
NeuroHIV 病理性自发皮质动力学和炎症的抑制
- 批准号:
10590619 - 财政年份:2022
- 资助金额:
$ 75.08万 - 项目类别:
Suppression of Pathological Spontaneous Cortical Dynamics and Inflammation in NeuroHIV
NeuroHIV 病理性自发皮质动力学和炎症的抑制
- 批准号:
10472343 - 财政年份:2022
- 资助金额:
$ 75.08万 - 项目类别: