Center for Pediatric Brain Health

儿科脑健康中心

• 批准号: 10798920
• 负责人: Tony W Wilson
• 金额: $ 25万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798920
• 关键词: 3D Print; Acceleration; Administrative Supplement; Adolescent; Adult; Area; BRAIN initiative; Brain; Brain imaging; Centers of Research Excellence; Child; Childhood; Clip; Code; Cognitive; Communication; Coupling; Custom; Dedications; Development; Elements; Environment; Evolution; Extramural Activities; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Head; Helium; Hospitals; Human; Image; Immune; Infant; Infrastructure; Institution; International; Life; Liquid substance; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Magnetometries; Maps; Measurement; Measures; Mentors; Methods; Modality; Motion; Movement; National Institute of General Medical Sciences; Nebraska; Neurologic; Neurons; Neurosciences; Noise; North America; Optics; Parents; Participant; Physics; Population; Predisposition; Productivity; Publishing; Pump; Research; Research Personnel; Research Project Grants; Scalp structure; Science; Scientist; Sensory; Shapes; Signal Transduction; Site; Social Interaction; Source; System; Techniques; Temperature; Time; Translating; Work; boys; brain health; cohort; data acquisition; density; design; high resolution imaging; imaging facilities; imaging modality; improved; innovation; insight; instrumentation; magnetic field; millimeter; millisecond; neonate; neural; neuroimaging; neurophysiology; programs; quantum; sensor; square foot; temporal measurement

Abstract/Summary: Administrative Supplement for the Center for Pediatric Brain Health The Center for Pediatric Brain Health is a NIGMS COBRE at Boys Town National Research Hospital (BTNRH) that recently entered its second year. The Center is housed in the new, state-of-the-art, 15,000+ square foot Institute for Human Neuroscience building on the main Boys Town campus. The key components of the Center include the Administrative Core, one research core (i.e., the Neural Quantification and Imaging Core), four research project leaders (RPLs), a Supervisory and Mentoring Committee, and a cohort of established pediatric neuroscientists. The Center has unique strengths in the area of dynamic neuroimaging, with one of the largest and most productive magnetoencephalography (MEG) groups in the world. MEG is a noninvasive neuroimaging method with millimeter spatial precision and millisecond temporal resolution that is ideal for studying children due to its open, non-claustrophobic design and completely silent data acquisition environment. However, like MRI and other human neuroimaging modalities, the method is susceptible to participant movement, which has typically limited its application to children who are typically about six years or older. In 2022, the Center for Pediatric Brain Health installed the first high-density optically-pumped magnetometry (OPM) unit in North America. OPM is a new method that measures the same magnetic fields detected in MEG but does so by harnessing recent breakthroughs in quantum physics that were rapidly accelerated by President Obama’s BRAIN Initiative. These key breakthroughs allow the sensors to operate at room temperature and be placed directly on the scalp, which means the measured magnetic fields are much stronger than in MEG (i.e., improved signal-to-noise ratio) and the sensors move with the head. The latter quality means that OPM is much more tolerant of head motion than MEG, MRI, and other comparable imaging modalities and thus enables high resolution imaging in very young children. Our current OPM array contains 128-channels and is optimized for older adolescents and adults and has been used extensively despite the short time since installation. During this time, we have also made custom arrays for babies as young as three-months-old by attaching the OPM sensors to baby hats (e.g., beanie caps) using custom 3D-printed clips. While such innovation has helped move us forward, a dedicated array for neonates, infants, and other very young children would revolutionize this work and lead to high precision dynamic functional maps of neural activity from babies at the earliest stages of life. Further, such a second array would allow “hyper-scanning” of parent-child dyads and illuminate how some of the most important social interactions in life shape the trajectory of brain development thereafter. Thus, through this administrative supplement and significant institutional funding, we are requesting support to acquire, install, and integrate a 64-channel OPM array for advancing pediatric neuroscience. When complete, this OPM system will be the first of its kind in the world and advance multiple research programs associated with our Center, while also establishing the Center as an international hub for developmental neuroscience.

摘要/总结：儿科脑健康中心的行政补充 儿科脑健康中心是男孩镇国家研究医院 (BTNRH) 的 NIGMS COBRE 最近进入了第二年。该中心坐落在全新的、最先进的、超过 15,000 平方英尺的场地内 人类神经科学研究所大楼位于男孩城主校区。中心的主要组成部分 包括行政核心、一个研究核心（即神经量化和成像核心）、四个 研究项目负责人 (RPL)、监督和指导委员会以及一群已建立的儿科专家 神经科学家。该中心在动态神经影像领域具有独特的优势，是最大的中心之一 以及世界上最具生产力的脑磁图 (MEG) 小组。 MEG是一种无创神经影像学 具有毫米级空间精度和毫秒级时间分辨率的方法，非常适合儿童研究 由于其开放式、非幽闭设计和完全安静的数据采集环境。然而，就像 MRI 和其他人类神经成像方式，该方法容易受到参与者运动的影响，这 通常将其应用限制为通常大约六岁或以上的儿童。 2022 年，儿科脑健康中心安装了第一个高密度光泵磁力测量仪 (OPM) 北美单位。 OPM 是一种测量 MEG 中检测到的相同磁场的新方法 但这是通过利用总统迅速加速的量子物理学的最新突破来实现的 奥巴马的大脑计划。这些关键突破使得传感器能够在室温下运行并可 直接放置在头皮上，这意味着测量到的磁场比 MEG 强得多（即 提高了信噪比）并且传感器随头部移动。后者的质量意味着 OPM 多 比 MEG、MRI 和其他类似的成像方式更能容忍头部运动，从而实现高 幼儿的分辨率成像。我们当前的 OPM 阵列包含 128 个通道，并针对 尽管安装时间很短，但已被广泛使用。期间 这次，我们还为三个月大的婴儿制作了定制阵列，附加了 OPM 使用定制 3D 打印夹子将传感器安装到婴儿帽（例如无檐小便帽）。虽然此类创新有所帮助 推动我们前进，专门针对新生儿、婴儿和其他幼儿的阵列将带来革命性的变化 这项工作最早可以得出婴儿神经活动的高精度动态功能图 人生的各个阶段。此外，这样的第二个阵列将允许对父子二元组进行“超级扫描”并照亮 生活中一些最重要的社交互动如何塑造此后大脑发育的轨迹。 因此，通过这一行政补充和大量机构资助，我们请求支持 获取、安装和集成 64 通道 OPM 阵列，以推进儿科神经科学。完成后， 该 OPM 系统将是世界上同类系统中的第一个，并推进多个相关研究项目 与我们的中心合作，同时还将该中心建成发育神经科学的国际中心。

项目成果

Auditory experience modulates fronto-parietal theta activity serving fluid intelligence.

• DOI: 10.1093/braincomms/fcac093
• 发表时间: 2022
• 期刊: Brain communications
• 影响因子: 4.8

The development of sensorimotor cortical oscillations is mediated by pubertal testosterone.

• DOI: 10.1016/j.neuroimage.2022.119745
• 发表时间: 2022-12-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Fung, Madison H.;Heinrichs-Graham, Elizabeth;Taylor, Brittany K.;Frenzel, Michaela R.;Eastman, Jacob A.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.

Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth.

• DOI: 10.1016/j.dcn.2023.101257
• 发表时间: 2023-06
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Killanin, Abraham D.;Taylor, Brittany K.;Embury, Christine M.;Picci, Giorgia;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Heinrichs-Graham, Elizabeth;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.

Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.

• DOI: 10.1192/j.eurpsy.2022.2325
• 发表时间: 2022-10-13
• 期刊: EUROPEAN PSYCHIATRY
• 影响因子: 7.8
• 作者: Kerr-German, Anastasia;White, Stuart F.;Santosa, Hendrik;Buss, Aaron T.;Doucet, Gaelle E.
• 通讯作者: Doucet, Gaelle E.

Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.

• DOI: 10.1016/j.ynstr.2023.100599
• 发表时间: 2024-03
• 期刊: NEUROBIOLOGY OF STRESS
• 影响因子: 5
• 作者: Schantell, Mikki;Mansouri, Amirsalar;Arif, Yasra;Rice, Danielle L.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.