Alteration and Renovation

摘要/摘要：改建与改造 拟议的改建和翻新项目将创建一个光泵磁测(OPM)套件 对于儿科脑健康中心的研究人员。OPM是一种新兴的记录人类的技术 神经生理信号以高空间和时间精度的非侵入性。技术完全是沉默的， 重量轻，特别独特的是，记录阵列具有高度延展性，可以作为帽子佩戴。 这种灵活性使这项技术成为幼儿甚至婴儿的理想选择，因为盖子可以紧紧地安装在 头部较小。此外，由于设备是安装在人身上的，因此相对于其他设备，移动问题较小 脑成像方法(例如，功能磁共振成像、脑磁图等)，这再次使其成为研究儿童的理想选择。vt.给出 这些特性以及该中心在神经生理学和脑动力学方面的主要优势，我们预计 OPM系统将被中心调查人员广泛使用，包括四个Cobre中的至少两个 研究项目负责人(RPL)。因此，我们建议完成一套OPM套房，并建造一个磁性- 屏蔽室，以容纳OPM传感器阵列通过这个翻新项目。一旦翻修完成， 男童镇国立研究医院(BTNRH)将支持购买最先进的OPM系统。 正如申请书中其他地方所述，新的儿科脑健康中心将设在该研究所 位于BTNRH的人类神经科学大楼，这是他们主校园内的一个新的15,000平方英尺的设施。 这座建筑于2020年基本完工，仅剩的未完工面积约为245平方英尺 与研究所的一些其他成像设备相邻的双脚房间，以及地下室的一部分。 这个约245平方英尺的空间位于地面，最初被指定为可能的地点 未来的OPM系统，考虑到它距离MRI的距离、整体噪声水平低等参数。然而， 这个空间在主要施工期间没有完工，因为精确的尺寸和重量 被屏蔽的房间的部分是未知的，这些是完成水泥工作所需的。因此，我们建议 将这个空间改造成一个全面运营的OPM套件。该项目将涉及广泛的水泥工作，以 创建一个18英寸深，10英寸见方的坑来容纳屏蔽房间，以及对机械的修改， 电气和为房间提供服务的其他建筑系统。新的天花板、隔音材料、地板和橱柜将 也可以安装。最后，将在坑内建造一个双层、高性能的磁屏蔽室。 整个扩建计划由Leo A.Daly建筑公司设计，霍金斯建筑公司 完成这项工作。屏蔽室将由Cerca Magnetics建造。我们预计所有的施工都将是 在科布雷供资的第一年期间完成，OPM系统将在 第二年年中。一旦投入使用，OPM套件将由中心的神经网络进行管理和支持 量化与成像核心。

Abstract/Summary: Alteration & Renovation The proposed alteration and renovation project would create an optically-pumped magnetometry (OPM) suite for investigators in the Center for Pediatric Brain Health. OPM is an emerging technology for recording human neurophysiological signals noninvasively at high spatial and temporal precision. The technology is totally silent, lightweight, and especially unique in that the recording array is highly malleable and can be worn as a cap. This flexibility makes the technology ideal for young children and even infants, as the cap can be tightly fitted to smaller heads. Further, since the device is fitted to the person, movement is less problematic relative to other brain imaging methods (e.g., functional MRI, MEG, etc.), which again makes it ideal for studying children. Given these properties and the Center’s major strengths in neurophysiology and brain dynamics, we anticipate that an OPM system would be widely utilized by Center investigators, including at least two of the four COBRE research project leaders (RPLs). Thus, we propose to finish-out an OPM suite and construct a magnetically- shielded room to house the OPM sensor array through this renovation project. Once the renovation is complete, Boys Town National Research Hospital (BTNRH) will support the purchase of a state-of-the-art OPM system. As stated elsewhere in the application, the new Center for Pediatric Brain Health would reside in the Institute for Human Neuroscience building at BTNRH, which is a new 15,000+ square feet facility on their main campus. This building was largely completed in 2020, with the only remaining unfinished areas being a ~245 square feet room that is adjacent to some of the Institute’s other imaging equipment, and a portion of the basement. The ~245 square feet space sits on the ground level and was originally designated as a possible site for a future OPM system, given its distance from the MRI, low overall noise level, and other parameters. However, the space was left unfinished during the major construction period because the precise dimensions and weight of the shielded room were unknown, and these were needed to complete the cement work. Thus, we propose to transform this space into a fully-operational OPM suite. The project will involve extensive cement work to create an 18” deep, 10’2” square pit to hold the shielded room, as well as modifications to the mechanical, electrical, and other building systems serving the room. New ceiling, sound-proofing, flooring, and cabinetry will also be installed. Finally, a two-layer, high-performance magnetically-shielded room will be built within the pit. The overall build-out plans were designed by the Leo A. Daly architectural firm, with Hawkins construction performing the work. The shielded room would be built by Cerca Magnetics. We expect all construction to be completed during year one of the COBRE funding and that the OPM system would be fully operational by the middle of year two. Once operational, the OPM suite would be managed and supported by the Center’s Neural Quantification & Imaging Core.