Alteration and Renovation

摘要/摘要：改建和翻新 拟议的改建和翻新项目将创建一个光泵磁力测量（OPM）套件 儿童脑健康中心的研究人员。OPM是一种新兴的记录人类活动的技术 神经生理信号的非侵入性的高空间和时间精度。这项技术是完全无声的， 重量轻，并且特别独特的是，记录阵列具有高度延展性，并且可以作为帽子佩戴。 这种灵活性使该技术成为幼儿甚至婴儿的理想选择，因为帽子可以紧紧地安装在 更小的头此外，由于该装置被装配到人，因此相对于其他装置，移动问题较少。 脑成像方法（例如，功能性MRI、MEG等），这也使得它成为研究儿童的理想工具。给定 这些特性和中心在神经生理学和大脑动力学方面的主要优势，我们预计， 中心的调查人员将广泛使用OPM系统，包括4个COBRE中的至少2个 研究项目负责人（RPLs）。因此，我们建议完成一个OPM套件，并构建一个磁- 通过这一改造项目，我们将建造一个屏蔽室来容纳OPM传感器阵列。一旦装修完成， 男孩镇国家研究医院（BTNRH）将支持购买最先进的OPM系统。 如申请书中其他地方所述，新的儿科脑健康中心将设在研究所内。 BTNRH的人类神经科学大楼，这是他们主校区的一个新的15，000多平方英尺的设施。 该建筑于2020年基本完工，仅剩下245平方米的未完工区域 这是毗邻研究所的一些其他成像设备，和地下室的一部分。 这个约245平方英尺的空间位于一楼，最初被指定为一个可能的地点， 考虑到其与MRI的距离、低的总体噪声水平和其他参数，未来的OPM系统。但是，在这方面， 在主要施工期间，该空间未完成，因为精确的尺寸和重量 这些都是完成水泥工程所需要的。因此，我们建议 把这个空间变成一个完全运作的OPM套件。该项目将涉及大量的水泥工程， 创建一个18英寸深，10英尺2英寸的正方形坑来容纳屏蔽室，以及对机械， 电力和其他服务于房间的建筑系统。新的天花板，隔音，地板和橱柜将 也可以安装。最后，将在坑内建造一个两层高性能磁屏蔽室。 整体扩建计划由Leo A.戴利建筑公司，和霍金斯建筑公司 执行工作。屏蔽室将由Cerca Magnetics建造。我们希望所有的建设都是 在COBRE供资的第一年完成，OPM系统将在2010年前全面运作。 第二年的中间。一旦投入使用，OPM套件将由中心的神经网络管理和支持。 量化和成像核心。

Abstract/Summary: Alteration & Renovation The proposed alteration and renovation project would create an optically-pumped magnetometry (OPM) suite for investigators in the Center for Pediatric Brain Health. OPM is an emerging technology for recording human neurophysiological signals noninvasively at high spatial and temporal precision. The technology is totally silent, lightweight, and especially unique in that the recording array is highly malleable and can be worn as a cap. This flexibility makes the technology ideal for young children and even infants, as the cap can be tightly fitted to smaller heads. Further, since the device is fitted to the person, movement is less problematic relative to other brain imaging methods (e.g., functional MRI, MEG, etc.), which again makes it ideal for studying children. Given these properties and the Center’s major strengths in neurophysiology and brain dynamics, we anticipate that an OPM system would be widely utilized by Center investigators, including at least two of the four COBRE research project leaders (RPLs). Thus, we propose to finish-out an OPM suite and construct a magnetically- shielded room to house the OPM sensor array through this renovation project. Once the renovation is complete, Boys Town National Research Hospital (BTNRH) will support the purchase of a state-of-the-art OPM system. As stated elsewhere in the application, the new Center for Pediatric Brain Health would reside in the Institute for Human Neuroscience building at BTNRH, which is a new 15,000+ square feet facility on their main campus. This building was largely completed in 2020, with the only remaining unfinished areas being a ~245 square feet room that is adjacent to some of the Institute’s other imaging equipment, and a portion of the basement. The ~245 square feet space sits on the ground level and was originally designated as a possible site for a future OPM system, given its distance from the MRI, low overall noise level, and other parameters. However, the space was left unfinished during the major construction period because the precise dimensions and weight of the shielded room were unknown, and these were needed to complete the cement work. Thus, we propose to transform this space into a fully-operational OPM suite. The project will involve extensive cement work to create an 18” deep, 10’2” square pit to hold the shielded room, as well as modifications to the mechanical, electrical, and other building systems serving the room. New ceiling, sound-proofing, flooring, and cabinetry will also be installed. Finally, a two-layer, high-performance magnetically-shielded room will be built within the pit. The overall build-out plans were designed by the Leo A. Daly architectural firm, with Hawkins construction performing the work. The shielded room would be built by Cerca Magnetics. We expect all construction to be completed during year one of the COBRE funding and that the OPM system would be fully operational by the middle of year two. Once operational, the OPM suite would be managed and supported by the Center’s Neural Quantification & Imaging Core.