Alteration and Renovation

改建和翻新

• 批准号: 10346723
• 负责人: Tony W Wilson
• 金额: $ 30万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346723
• 关键词: Adult; Aluminum; Architecture; Area; Brain; Brain imaging; Centers of Research Excellence; Child; Childhood; Copper; Custom; Development; Devices; Dimensions; Electronics; Emerging Technologies; Equipment; Faculty; Floor; Functional Magnetic Resonance Imaging; Funding; Future; Head; Home; Hospitals; Human; Image; Imaging Device; Infant; Institutes; Left; Letters; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Magnetometries; Measurement; Mechanics; Modification; Morphologic artifacts; Movement; Nebraska; Neurosciences; Noise; Optics; Participant; Performance; Peripheral; Persons; Property; Pump; Research; Research Personnel; Research Project Grants; Scientist; Signal Transduction; Site; Stimulus; Support System; System; Talents; Technology; Weight; Work; advanced system; boys; brain health; brain research; design; flexibility; imaging modality; innovation; light weight; neuroimaging; neurophysiology; new technology; novel; recruit; relating to nervous system; sensor; sound; square foot

Abstract/Summary: Alteration & Renovation The proposed alteration and renovation project would create an optically-pumped magnetometry (OPM) suite for investigators in the Center for Pediatric Brain Health. OPM is an emerging technology for recording human neurophysiological signals noninvasively at high spatial and temporal precision. The technology is totally silent, lightweight, and especially unique in that the recording array is highly malleable and can be worn as a cap. This flexibility makes the technology ideal for young children and even infants, as the cap can be tightly fitted to smaller heads. Further, since the device is fitted to the person, movement is less problematic relative to other brain imaging methods (e.g., functional MRI, MEG, etc.), which again makes it ideal for studying children. Given these properties and the Center’s major strengths in neurophysiology and brain dynamics, we anticipate that an OPM system would be widely utilized by Center investigators, including at least two of the four COBRE research project leaders (RPLs). Thus, we propose to finish-out an OPM suite and construct a magnetically- shielded room to house the OPM sensor array through this renovation project. Once the renovation is complete, Boys Town National Research Hospital (BTNRH) will support the purchase of a state-of-the-art OPM system. As stated elsewhere in the application, the new Center for Pediatric Brain Health would reside in the Institute for Human Neuroscience building at BTNRH, which is a new 15,000+ square feet facility on their main campus. This building was largely completed in 2020, with the only remaining unfinished areas being a ~245 square feet room that is adjacent to some of the Institute’s other imaging equipment, and a portion of the basement. The ~245 square feet space sits on the ground level and was originally designated as a possible site for a future OPM system, given its distance from the MRI, low overall noise level, and other parameters. However, the space was left unfinished during the major construction period because the precise dimensions and weight of the shielded room were unknown, and these were needed to complete the cement work. Thus, we propose to transform this space into a fully-operational OPM suite. The project will involve extensive cement work to create an 18” deep, 10’2” square pit to hold the shielded room, as well as modifications to the mechanical, electrical, and other building systems serving the room. New ceiling, sound-proofing, flooring, and cabinetry will also be installed. Finally, a two-layer, high-performance magnetically-shielded room will be built within the pit. The overall build-out plans were designed by the Leo A. Daly architectural firm, with Hawkins construction performing the work. The shielded room would be built by Cerca Magnetics. We expect all construction to be completed during year one of the COBRE funding and that the OPM system would be fully operational by the middle of year two. Once operational, the OPM suite would be managed and supported by the Center’s Neural Quantification & Imaging Core.

摘要/总结：改造与翻新 拟议的改建和翻新项目将创建光泵磁力测量 (OPM) 套件 供儿科脑健康中心的研究人员使用。 OPM是一项新兴的人类录音技术 以高空间和时间精度无创地发出神经生理信号。该技术完全静音， 重量轻，特别独特的是记录阵列具有高度可塑性，可以作为帽子佩戴。 这种灵活性使得该技术非常适合幼儿甚至婴儿，因为盖子可以紧密地安装在 较小的头。此外，由于该设备是贴合在人身上的，因此相对于其他设备而言，移动问题较少。 脑成像方法（例如功能性 MRI、MEG 等），这再次使其成为研究儿童的理想选择。给定 这些特性以及该中心在神经生理学和大脑动力学方面的主要优势，我们预计 OPM 系统将被中心调查员广泛使用，包括四个 COBRE 中的至少两个 研究项目负责人（RPL）。因此，我们建议完成一个 OPM 套件并构建一个磁性- 通过本次改造项目，屏蔽室可容纳 OPM 传感器阵列。装修完成后， Boys Town 国家研究医院 (BTNRH) 将支持购买最先进的 OPM 系统。 正如申请中其他地方所述，新的儿科脑健康中心将设在该研究所 BTNRH 的人类神经科学大楼是其主校区内一座占地 15,000 多平方英尺的新设施。 该建筑于 2020 年基本完工，仅剩下约 245 平方米的未完工面积 脚室毗邻研究所的一些其他成像设备，以及地下室的一部分。 约 245 平方英尺的空间位于地面，最初被指定为可能的场地 考虑到其与 MRI 的距离、较低的总体噪声水平和其他参数，未来的 OPM 系统。然而， 由于精确的尺寸和重量，该空间在主要施工期间未完工 屏蔽室的具体情况未知，而这些是完成水泥工作所必需的。因此，我们建议 将这个空间转变为一个完全可操作的 OPM 套件。该项目将涉及大量水泥工程 创建一个 18 英寸深、10 英尺 2 英寸的方形坑来容纳屏蔽室，并对机械、 电气和其他为房间服务的建筑系统。新的天花板、隔音、地板和橱柜将 也可以安装。最后，坑内将建造一个两层高性能磁屏蔽室。 总体规划由 Leo A. Daly 建筑公司设计，霍金斯施工 执行工作。屏蔽室将由 Cerca Magnetics 建造。我们期望所有的建设 在 COBRE 资助的第一年完成，OPM 系统将由 第二年中期。一旦投入运行，OPM 套件将由该中心的神经网络进行管理和支持 量化和成像核心。