Center for Pediatric Brain Health

摘要/总结：整体组件 该生物医学研究卓越中心（COBRE）的申请将启动儿科中心 大脑健康管理，支持和扩展发育神经成像和儿科神经科学研究 在内布拉斯加州奥马哈的男孩镇国家研究医院（BTNRH）。这是儿科医生 神经科学在BTNRH，作为一个组织范围内的倡议，以扩大在这一领域已经导致了许多 教师招聘和一个新的国家的最先进的15,000+平方英尺的人类神经科学研究所的建设。 拟议中的儿童脑健康中心将在一个中央机构下组织和支持这些新资源。 保护伞，并提供关键计划，以帮助发展社区，并围绕一个共同的 儿科神经科学和大脑健康的主题。该中心的主要组成部分包括一个行政 核心，一个研究核心（即，神经量化和成像核心），四个研究项目负责人（RPL）， 一个监督和指导委员会，和一群成熟的儿科神经科学家。开始时 该中心的行政核心将实施一个全面的研究支持结构，包括 辅导和职业发展资源，试点项目计划，广泛的培训机会，两个 独特的研讨会系列，社区推广，以及对关键研究基础设施的广泛支持（例如，参与者 注册，共享研究空间）。培训机会将包括技术讲习班以及实习 以及培养下一代研究生的博士后神经成像培训计划， 中心教员。与此同时，行政核心将推动启动四个RPL， 发展和评估系统，其中将包括一个监督和指导委员会，由10个 高级科学家，他们将监控进度，并确保每个RPL及其两名共同导师达到关键 里程碑最后，新的神经量化和成像核心将支持并提供对状态的直接访问， 最先进的儿科神经成像仪器，包括一个新的3特斯拉西门子Prisma磁铁，两个Neo 脑磁图（MEG）成像单元，模拟MRI扫描仪和其他主要设备，并将 为目前最先进的神经影像分析提供全面的分析支持。 值得注意的是，核心将是世界上唯一一个拥有两个MEG Neo系统的网站，用于量化人类大脑 动力学新中心还将支持一批资深科学家，他们的专业知识涵盖多个儿科领域。 不同的成像技术。最后，该中心将获得特殊的机构支持， 包括用于试点项目、核心人员配备、实习、主要设备费用和其他举措的资金， 将由托尼·威尔逊博士指导，他是一位具有丰富经验的发展认知神经科学家 在多模式神经成像和校外支持，出版物和指导的卓越记录。 总的来说，新的儿科脑健康中心拥有丰富的资源、支持和专业知识， 将确保它对BTNRH及其他地区的儿科神经科学研究产生重大的长期影响。

Abstract/Summary: Overall Component This application for a Center of Biomedical Research Excellence (COBRE) would initiate a Center for Pediatric Brain Health to manage, support, and expand developmental neuroimaging and pediatric neuroscience research at Boys Town National Research Hospital (BTNRH) in Omaha, Nebraska. It is an opportune moment for pediatric neuroscience at BTNRH, as an organization-wide initiative to expand in this area has resulted in numerous faculty hires and the construction of a new state-of-the-art 15,000+ square feet Institute for Human Neuroscience. The proposed Center for Pediatric Brain Health will organize and support these new resources under a central umbrella, and provide critical programs to help grow the community and build cohesiveness around a common theme of pediatric neuroscience and brain health. The key components of the Center include an Administrative Core, one research core (i.e., the Neural Quantification & Imaging Core), four research project leaders (RPLs), a Supervisory & Mentoring Committee, and a cohort of established pediatric neuroscientists. Upon initiation of the Center, the Administrative Core will implement a comprehensive research support structure that includes mentoring and career developing resources, a pilot projects program, extensive training opportunities, two distinct seminar series, community outreach, and broad support of key research infrastructure (e.g., participant registry, shared research spaces). Training opportunities will include technical workshops, as well as internships and a postdoctoral neuroimaging training program for fostering the next generation of graduate students and Center faculty. In parallel, the Administrative Core will promote the launch of four RPLs and implement a career development and evaluation system, which will include a Supervisory & Mentoring Committee comprised of 10 senior scientists who will monitor progress and ensure each RPL and their two co-mentors reach critical milestones. Finally, the new Neural Quantification & Imaging Core will support and provide direct access to state- of-the-art instrumentation for pediatric neuroimaging, including a new 3-Tesla Siemens Prisma magnet, two Neo magnetoencephalographic (MEG) imaging units, a mock MRI scanner, and other major equipment, and will provide comprehensive analytical support for the most advanced neuroimaging analyses currently available. Notably, the Core will be the only site in the world to host two MEG Neo systems for quantifying human brain dynamics. The new Center will also support a cohort of senior scientists with expertise spanning multiple pediatric populations and different imaging technologies. Finally, the Center will receive exceptional institutional support, including funds for pilot projects, Core staffing, internships, major equipment expenses, and other initiatives, and will be directed by Dr. Tony Wilson who is a developmental cognitive neuroscientist with extensive experience in multimodal neuroimaging and an exceptional track record of extramural support, publications, and mentoring. Taken together, the expansive resources, support, and expertise within the new Center for Pediatric Brain Health will ensure that it has a major long-term impact on pediatric neuroscience research at BTNRH and beyond.