Neural Quantification & Imaging Core

摘要/综述：神经量化与成像核心 神经量化和成像核心将管理、支持和提供对主要设备的访问 和儿科脑健康中心的资源。它将是该中心唯一的研究核心，并将 位于Boys town National Research的新的15,000平方英尺的人类神经科学研究所 医院(BTNRH)。核心将为Cobre的所有四项研究提供关键支持和基础设施 项目负责人(RPL)，以及与研究所相关的一系列既定研究方案 以及更广泛的BTNRH。核心的关键设备和资源将包括两个最新的- 用于记录和成像神经振荡的ART Triux新脑磁图(MEG)系统，3-特斯拉 西门子Prisma磁共振扫描仪配备高性能梯度和通道磁头线圈 分辨率结构、功能、扩散和光谱成像，以及一个逼真的模拟扫描仪 儿童和其他参与者为幽闭恐惧症和嘈杂的核磁共振环境做准备。此外，核心 将运作一套脑刺激套件，丰富的计算和数据处理资源，全面 分析支持，并在不久的将来推出超现代光泵磁测(OPM)系统，用于 先进的神经生理学测量。神经量化和成像核心也将至少承载 每年两次神经成像研讨会，通过中心的试点项目支持有针对性的设备使用 计划，并作为中心通过博士后神经成像支持的研究员的大本营 培训计划。核心将由托尼·威尔逊博士执导，他是多模式神经成像方面的专家 在脑磁图成像、结构和功能磁共振成像、脑刺激和其他方面有20多年的经验 高级人类神经科学研究的工具和分析方法。核心的工作人员还将包括一名 专门负责脑磁图和核磁共振系统的现场工程师/物理学家和技术人员。在财务方面，核心将是 由仪器使用费、BTNRH和COBRE支持，BTNRH弥补任何年度赤字 以及所有资本折旧。作为BTNRH唯一能够测量生物生物参数的核心 人脑，该设施将填补该机构整体研究基础设施中的一个主要空白，并成为关键 这是儿科脑健康中心成功的一个重要因素。

Abstract/Summary: Neural Quantification & Imaging Core The Neural Quantification & Imaging Core will manage, support, and provide access to the major equipment and resources of the Center for Pediatric Brain Health. It will be the only research core of the Center and will be housed in the new 15,000+ square feet Institute for Human Neuroscience at Boys Town National Research Hospital (BTNRH). The Core will provide critical support and infrastructure to all four of the COBRE research project leaders (RPLs), as well as a collection of established research programs associated with the Institute and across BTNRH more broadly. The key equipment and resources of the Core will include two state-of-the- art Triux Neo magnetoencephalography (MEG) systems for recording and imaging neural oscillations, a 3-Tesla Siemens Prisma MRI scanner equipped with high-performance gradients and a 64-channel head coil for high- resolution structural, functional, diffusion, and spectroscopic imaging, and a realistic mock scanner for helping children and other participants prepare for the claustrophobic and loud MRI environment. In addition, the Core will operationalize a brain stimulation suite, extensive computing and data processing resources, comprehensive analytical support, and in the near future, an ultra-modern optically-pumped magnetometry (OPM) system for advanced neurophysiological measurements. The Neural Quantification & Imaging Core will also host at least two neuroimaging workshops per year, support targeted equipment usage through the Center’s pilot projects program, and serve as the home base for fellows supported through the Center’s postdoctoral neuroimaging training program. The Core will be directed by Dr. Tony Wilson, who is an expert in multimodal neuroimaging with over 20 years of experience with MEG imaging, structural and functional MRI, brain stimulation, and other tools and analytical approaches for advanced human neuroscience research. The Core’s staff will also include a dedicated site engineer/physicist and technicians for the MEG and MRI systems. Financially, the Core will be supported by instrument use fees, BTNRH, and the COBRE, with BTNRH covering any year-to-year deficits and all capital depreciation. As the only Core at BTNRH capable of measuring biological parameters of the living human brain, the facility will fill a major void in the institution’s overall research infrastructure and be a critical component to the success of the Center for Pediatric Brain Health.