Neural Quantification & Imaging Core

神经量化

• 批准号: 10346725
• 负责人: Tony W Wilson
• 金额: $ 50.84万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346725
• 关键词: Adult; Biological; Brain; Capital; Centers of Research Excellence; Child; Childhood; Collection; Communities; Community Health; Computer software; Core Facility; Data; Data Analyses; Data Analytics; Depreciation; Devices; Diffusion; Educational workshop; Engineering; Ensure; Environment; Equipment; Experimental Designs; Extramural Activities; Faculty; Fees; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Growth; Head; High Performance Computing; Home; Hospitals; Human; Image; Infant; Infrastructure; Institutes; Institution; International; Internships; Laboratories; Loudness; Magnetic Resonance Imaging; Magnetoencephalography; Magnetometries; Measurement; Measures; Mentors; Methods; Mission; Modality; Modernization; Neurosciences; Neurosciences Research; Optics; Participant; Performance; Perfusion; Pilot Projects; Play; Population; Positioning Attribute; Postdoctoral Fellow; Protocols documentation; Publications; Publishing; Pump; Research; Research Infrastructure; Research Project Grants; Research Support; Resolution; Resources; Role; Scientist; Site; Spectrum Analysis; Stretching; Structure; System; Technical Expertise; Techniques; Training; Training Programs; Work; advanced system; analytical method; base; boys; brain health; brain research; computerized data processing; connectome; data acquisition; experience; experimental study; improved; instrument; instrumentation; laboratory experience; mid-career faculty; multimodal neuroimaging; multimodality; neuroimaging; neurophysiology; neuroregulation; new technology; novel; post-doctoral training; prisma; programs; relating to nervous system; research and development; spectroscopic imaging; square foot; success; tool

Abstract/Summary: Neural Quantification & Imaging Core The Neural Quantification & Imaging Core will manage, support, and provide access to the major equipment and resources of the Center for Pediatric Brain Health. It will be the only research core of the Center and will be housed in the new 15,000+ square feet Institute for Human Neuroscience at Boys Town National Research Hospital (BTNRH). The Core will provide critical support and infrastructure to all four of the COBRE research project leaders (RPLs), as well as a collection of established research programs associated with the Institute and across BTNRH more broadly. The key equipment and resources of the Core will include two state-of-the- art Triux Neo magnetoencephalography (MEG) systems for recording and imaging neural oscillations, a 3-Tesla Siemens Prisma MRI scanner equipped with high-performance gradients and a 64-channel head coil for high- resolution structural, functional, diffusion, and spectroscopic imaging, and a realistic mock scanner for helping children and other participants prepare for the claustrophobic and loud MRI environment. In addition, the Core will operationalize a brain stimulation suite, extensive computing and data processing resources, comprehensive analytical support, and in the near future, an ultra-modern optically-pumped magnetometry (OPM) system for advanced neurophysiological measurements. The Neural Quantification & Imaging Core will also host at least two neuroimaging workshops per year, support targeted equipment usage through the Center’s pilot projects program, and serve as the home base for fellows supported through the Center’s postdoctoral neuroimaging training program. The Core will be directed by Dr. Tony Wilson, who is an expert in multimodal neuroimaging with over 20 years of experience with MEG imaging, structural and functional MRI, brain stimulation, and other tools and analytical approaches for advanced human neuroscience research. The Core’s staff will also include a dedicated site engineer/physicist and technicians for the MEG and MRI systems. Financially, the Core will be supported by instrument use fees, BTNRH, and the COBRE, with BTNRH covering any year-to-year deficits and all capital depreciation. As the only Core at BTNRH capable of measuring biological parameters of the living human brain, the facility will fill a major void in the institution’s overall research infrastructure and be a critical component to the success of the Center for Pediatric Brain Health.

摘要/总结：神经量化和成像核心 神经量化和成像核心将管理，支持和提供对主要设备的访问 和儿科脑健康中心的资源。它将是该中心唯一的研究核心， 位于Boys Town National Research的15，000多平方英尺的人类神经科学研究所 医院（BTNRH）。核心将为所有四个COBRE研究提供关键支持和基础设施 项目负责人（RPL），以及与研究所相关的一系列既定研究计划 以及更广泛的BTNRH。核心的关键设备和资源将包括两个国家的- art Triux Neo脑磁图（MEG）系统，用于记录和成像神经振荡，3特斯拉 西门子Prisma MRI扫描仪配备高性能梯度和64通道头部线圈， 分辨率结构，功能，扩散和光谱成像，以及一个现实的模拟扫描仪，以帮助 儿童和其他参与者为幽闭恐怖症和嘈杂的MRI环境做准备。另外核心 将运作一个大脑刺激套件，广泛的计算和数据处理资源，全面的 分析支持，并在不久的将来，一个超现代的光泵磁力测量（OPM）系统， 先进的神经生理学测量神经量化和成像核心还将至少 每年举办两次神经成像研讨会，通过中心的试点项目支持有针对性的设备使用 计划，并作为通过该中心的博士后神经影像支持研究员的大本营 培训计划。核心将由托尼·威尔逊博士指导，他是多模式神经成像专家 拥有超过20年的MEG成像、结构和功能MRI、脑刺激等经验 先进的人类神经科学研究的工具和分析方法。核心的工作人员还将包括一名 MEG和MRI系统的专用现场工程师/物理学家和技术人员。在财务上，核心将是 由仪器使用费、BTNRH和COBRE支持，BTNRH覆盖任何年度赤字 以及所有的资本折旧。作为BTNRH唯一能够测量生物参数的核心， 人类大脑，该设施将填补该机构整体研究基础设施的主要空白， 儿童脑健康中心的成功的组成部分。