Neural Quantification & Imaging Core

神经量化

• 批准号: 10346725
• 负责人: Tony W Wilson
• 金额: $ 50.84万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346725
• 关键词: Adult; Biological; Brain; Capital; Centers of Research Excellence; Child; Childhood; Collection; Communities; Community Health; Computer software; Core Facility; Data; Data Analyses; Data Analytics; Depreciation; Devices; Diffusion; Educational workshop; Engineering; Ensure; Environment; Equipment; Experimental Designs; Extramural Activities; Faculty; Fees; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Growth; Head; High Performance Computing; Home; Hospitals; Human; Image; Infant; Infrastructure; Institutes; Institution; International; Internships; Laboratories; Loudness; Magnetic Resonance Imaging; Magnetoencephalography; Magnetometries; Measurement; Measures; Mentors; Methods; Mission; Modality; Modernization; Neurosciences; Neurosciences Research; Optics; Participant; Performance; Perfusion; Pilot Projects; Play; Population; Positioning Attribute; Postdoctoral Fellow; Protocols documentation; Publications; Publishing; Pump; Research; Research Infrastructure; Research Project Grants; Research Support; Resolution; Resources; Role; Scientist; Site; Spectrum Analysis; Stretching; Structure; System; Technical Expertise; Techniques; Training; Training Programs; Work; advanced system; analytical method; base; boys; brain health; brain research; computerized data processing; connectome; data acquisition; experience; experimental study; improved; instrument; instrumentation; laboratory experience; mid-career faculty; multimodal neuroimaging; multimodality; neuroimaging; neurophysiology; neuroregulation; new technology; novel; post-doctoral training; prisma; programs; relating to nervous system; research and development; spectroscopic imaging; square foot; success; tool

Abstract/Summary: Neural Quantification & Imaging Core The Neural Quantification & Imaging Core will manage, support, and provide access to the major equipment and resources of the Center for Pediatric Brain Health. It will be the only research core of the Center and will be housed in the new 15,000+ square feet Institute for Human Neuroscience at Boys Town National Research Hospital (BTNRH). The Core will provide critical support and infrastructure to all four of the COBRE research project leaders (RPLs), as well as a collection of established research programs associated with the Institute and across BTNRH more broadly. The key equipment and resources of the Core will include two state-of-the- art Triux Neo magnetoencephalography (MEG) systems for recording and imaging neural oscillations, a 3-Tesla Siemens Prisma MRI scanner equipped with high-performance gradients and a 64-channel head coil for high- resolution structural, functional, diffusion, and spectroscopic imaging, and a realistic mock scanner for helping children and other participants prepare for the claustrophobic and loud MRI environment. In addition, the Core will operationalize a brain stimulation suite, extensive computing and data processing resources, comprehensive analytical support, and in the near future, an ultra-modern optically-pumped magnetometry (OPM) system for advanced neurophysiological measurements. The Neural Quantification & Imaging Core will also host at least two neuroimaging workshops per year, support targeted equipment usage through the Center’s pilot projects program, and serve as the home base for fellows supported through the Center’s postdoctoral neuroimaging training program. The Core will be directed by Dr. Tony Wilson, who is an expert in multimodal neuroimaging with over 20 years of experience with MEG imaging, structural and functional MRI, brain stimulation, and other tools and analytical approaches for advanced human neuroscience research. The Core’s staff will also include a dedicated site engineer/physicist and technicians for the MEG and MRI systems. Financially, the Core will be supported by instrument use fees, BTNRH, and the COBRE, with BTNRH covering any year-to-year deficits and all capital depreciation. As the only Core at BTNRH capable of measuring biological parameters of the living human brain, the facility will fill a major void in the institution’s overall research infrastructure and be a critical component to the success of the Center for Pediatric Brain Health.

摘要/总结：神经量化和成像核心 神经量化和成像核心将管理、支持和提供对主要设备的访问 以及儿科脑健康中心的资源。它将成为该中心唯一的研究核心，并将 位于男孩镇国家研究院新建的 15,000 多平方英尺人类神经科学研究所 医院（BTNRH）。该核心将为所有四个 COBRE 研究提供关键支持和基础设施 项目负责人（RPL），以及与研究所相关的一系列既定研究项目 以及更广泛的 BTNRH。核心的关键设备和资源将包括两个最先进的- art Triux Neo 脑磁图 (MEG) 系统，用于记录和成像神经振荡，3-特斯拉 西门子 Prisma MRI 扫描仪配备高性能梯度和 64 通道头部线圈，可实现高 分辨率结构、功能、扩散和光谱成像，以及一个逼真的模拟扫描仪来帮助 儿童和其他参与者为幽闭恐惧症和嘈杂的 MRI 环境做好准备。此外，核心 将运行大脑刺激套件、广泛的计算和数据处理资源、全面的 分析支持，并且在不久的将来，超现代光泵磁力测量 (OPM) 系统可用于 先进的神经生理学测量。神经量化和成像核心还将至少主持 每年两次神经影像研讨会，通过中心的试点项目支持有针对性的设备使用 计划，并作为该中心博士后神经影像支持的研究员的大本营 培训计划。核心将由托尼·威尔逊博士指导，他是多模式神经影像学专家 在 MEG 成像、结构和功能 MRI、脑刺激等方面拥有 20 多年的经验 先进人类神经科学研究的工具和分析方法。核心人员还将包括 MEG 和 MRI 系统的专门现场工程师/物理学家和技术人员。在财务上，核心将是 由工具使用费、BTNRH 和 COBRE 支持，其中 BTNRH 涵盖任何年度赤字 以及所有资本折旧。作为 BTNRH 唯一能够测量生物体生物参数的核心 人脑，该设施将填补该机构整体研究基础设施的重大空白，并成为关键的 儿科脑健康中心成功的重要组成部分。