Health Disparities and SARS-COV-2 Evolution: A Focused Viral Genomics Study

健康差异和 SARS-COV-2 进化:一项重点病毒基因组学研究

基本信息

  • 批准号:
    10381371
  • 负责人:
  • 金额:
    $ 73.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-08-15 至 2022-08-04
  • 项目状态:
    已结题

项目摘要

Health Disparities and SARS-CoV-2 Evolution: A Focused Viral Genomics Study Project Summary/Abstract We hypothesize that prolonged COVID19 illness, re-infection, and/or post-vaccine infection in patients with chronic conditions are associated with specific SARS-CoV-2 lineages or mutations, and that increasing the awareness of the potential danger posed by variants of concern will improve testing adherence and variant tracking. We propose to use our established FDA- authorized COVID19 sequencing platform in combination with innovative data analytics and clinical bioinformatics as well as our BMI and community engagement KCAs. Our proposal addresses four of the priority areas indicated by NOT-GM-21-031, specifically: • Are there different variants present in the study population, and how has the number of cases caused by different variants changed over time in the study population? • How are different variants distributed among different racial, ethnical, gender, and/or age groups? • Are specific variants associated with different levels of manifestation of COVID19 symptoms? • Do vaccinated study participants still acquire the SARS-CoV-2 virus, and if so, what variants do they carry? We propose these Specific Aims: Specific Aim 1. To improve surveillance of COVID19 by integrating SARS-CoV-2 sequencing and clinical data with a focus on under-represented, vulnerable and remote populations. Using highly automated processes, we will identify variants/mutations associated with clinical phenotypes, including prolonged asymptomatic/antibody-positive individuals, re-infected, and vaccinated populations. All trend data will be integrated in the AWS cloud where it can be accessed by relevant stakeholders including testing and vaccine program partners. Specific Aim 2. To develop and validate simulation models that incorporate SARS-CoV-2 genetic data with clinical outcomes to predict COVID19 case severity in Louisiana by region as vaccination levels increase. Specific Aim 3. To design and deploy culturally and linguistically appropriate outreach material on SARS-CoV-2 and determine whether increased knowledge of the potential danger of adaptive mutations improves acceptance of testing and vaccination.
健康差异与SARS-CoV-2进化:一项集中的病毒基因组学研究

项目成果

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JOHN P. KIRWAN其他文献

JOHN P. KIRWAN的其他文献

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{{ truncateString('JOHN P. KIRWAN', 18)}}的其他基金

Louisiana Clinical and Translational Science Center
路易斯安那州临床和转化科学中心
  • 批准号:
    10415589
  • 财政年份:
    2021
  • 资助金额:
    $ 73.76万
  • 项目类别:
Louisiana Clinical and Translational Science Center
路易斯安那州临床和转化科学中心
  • 批准号:
    10258534
  • 财政年份:
    2020
  • 资助金额:
    $ 73.76万
  • 项目类别:
Role and Regulation of Skeletal Muscle Mitochondrial Dynamics in Type 2 Diabetes
骨骼肌线粒体动力学在 2 型糖尿病中的作用和调节
  • 批准号:
    9767119
  • 财政年份:
    2015
  • 资助金额:
    $ 73.76万
  • 项目类别:
Role of the skeletal muscle/pancreatic axis in type 2 diabetes
骨骼肌/胰轴在 2 型糖尿病中的作用
  • 批准号:
    9014518
  • 财政年份:
    2015
  • 资助金额:
    $ 73.76万
  • 项目类别:
Role and Regulation of Skeletal Muscle Mitochondrial Dynamics in Type 2 Diabetes
骨骼肌线粒体动力学在 2 型糖尿病中的作用和调节
  • 批准号:
    9336293
  • 财政年份:
    2015
  • 资助金额:
    $ 73.76万
  • 项目类别:
Role of the skeletal muscle/pancreatic axis in type 2 diabetes
骨骼肌/胰轴在 2 型糖尿病中的作用
  • 批准号:
    8815628
  • 财政年份:
    2015
  • 资助金额:
    $ 73.76万
  • 项目类别:
Louisiana Clinical and Translational Science Center - N3C supplement
路易斯安那临床和转化科学中心 - N3C 补充品
  • 批准号:
    10884657
  • 财政年份:
    2012
  • 资助金额:
    $ 73.76万
  • 项目类别:
Louisiana Clinical and Translational Science Center
路易斯安那州临床和转化科学中心
  • 批准号:
    10513330
  • 财政年份:
    2012
  • 资助金额:
    $ 73.76万
  • 项目类别:
Louisiana Clinical and Translational Science Center
路易斯安那州临床和转化科学中心
  • 批准号:
    10677678
  • 财政年份:
    2012
  • 资助金额:
    $ 73.76万
  • 项目类别:
LA CaTS Supplement NOT-OD-21-101
LA CatS 补充剂 NOT-OD-21-101
  • 批准号:
    10403313
  • 财政年份:
    2012
  • 资助金额:
    $ 73.76万
  • 项目类别:

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利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
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利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
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