Louisiana Clinical and Translational Science Center - N3C supplement

路易斯安那临床和转化科学中心 - N3C 补充品

• 批准号: 10884657
• 负责人: JOHN P. KIRWAN
• 金额: $ 34.67万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10884657
• 关键词: 2019-nCoV; Academic Medical Centers; Accreditation; Acute; Address; Administrative Supplement; Alabama; Applications Grants; Award; Big Data; Biomedical Research; Black race; COVID testing; COVID-19; COVID-19 pandemic; Case Study; Center for Translational Science Activities; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communities; Country; Data; Disease; Disparity; Dose; Eligibility Determination; Evolution; Future; Genomics; Grant; Growth; Health; Health Personnel; Health Sciences; Healthcare Systems; Hospitalization; Hurricane; Individual; Infection; Inosine Dialdehyde; Institution; Institutional Review Boards; Investments; Knowledge; Laboratories; Link; Long COVID; Louisiana; Mississippi; Modeling; Monitor; Outcome; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Population; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Productivity; Public Health; Publications; RADx Underserved Populations; Records; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; School Dentistry; Services; Source; System; T-Lymphocyte Epitopes; Time; Translational Research; Trust; United States Department of Veterans Affairs; Universities; Vaccinated; Vaccination; Vaccinee; Variant; Veterans; Viral; Vulnerable Populations; West Virginia; Work; Writing; Wyoming; biomedical informatics; breakthrough infection; clinical epidemiology; clinical risk; clinical translation; cohort; collaboratory; computable phenotypes; coronavirus disease; data enclave; experience; genetic epidemiology; genomic data; health data; health disparity; home test; improved; individual patient; pandemic disease; programs; self testing; transmission process; unvaccinated; viral genomics; viral transmission

Project Summary/Abstract The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center is the lead institution and will continue to partner with Louisiana State University Health (LSUH)-New Orleans and Tulane University Health Sciences Center in this initiative. LSUH-Shreveport, LSU-A&M (Baton Rouge), Xavier University and Children's Hospital New Orleans, were early Research Partners in cycle 1. Southeast Louisiana Veterans Healthcare System, a newly opened University Medical Center in New Orleans ($1 billion State investment), Ochsner Health and the LSUH-NO School of Dentistry joined during cycle 2. The LA CaTS Center is growing a unified clinical translational science program for Louisiana based on the creation of synergistic programs and unparalleled collaboration from all the major academic and biomedical research institutions in the state. Since inception 9 years ago, the LA CaTS Center has: 1) successfully leveraged resources and expertise of multiple participating institutions to build a vibrant statewide research infrastructure; 2) developed highly synergistic and integrative collaborative programs; 3) implemented a systematic approach to clinical research across all institutions, that includes a new SMART IRB Reliance Model review; and 4) implemented a highly effective governance system based on an unprecedented level of trust between partners. LA CaTS is experiencing exponential growth in research productivity as assessed by key metrics including a three-fold increase in external grant awards, a more than two-fold increase in publications with authors acknowledging LA CaTS Center resources and services and over 600 researchers benefiting from and using our services. Notably, during a period that has been marked by unique and unprecedented challenges from COVID and then Hurricane Ida, LA CaTS has achieved, and in many cases exceeded, its stated objectives and projected milestones. Indeed, since the COVID pandemic hit Louisiana in March of 2020, LA CaTS has led multiple successful grant applications for Administrative Supplements and NOSI awards, notably to facilitate COVID testing and vaccinations in underserved Black communities through the RADx-UP program and most recently our partnership with the IDeA state ISCORE consortium on the national Long-COVID initiative - Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)/RECOVER trial. However, we fully recognize that our work has only just begun, as we collectively address disparities and improve the lives of our citizens. It is also apparent, that slowly, but surely, we are impacting public health one project at a time! With new services proposed and the additional resources that will be added, our Center is uniquely positioned to devote our activities and resources to our major theme for the next 5- year cycle that will “address health disparities and improve the health outcomes of the citizens we serve”

项目总结/摘要 路易斯安那州临床和转化科学中心（LA CaTS）是一个由主要学术机构组成的联盟。 以及路易斯安那州的生物医学研究中心彭宁顿生物医学研究中心是 并将继续与路易斯安那州立大学健康（LSUH）-新奥尔良合作 和杜兰大学健康科学中心在这一倡议。LSUH-Shreveport，LSU-A&M（接力棒 Rouge）、泽维尔大学和新奥尔良儿童医院是第1周期的早期研究合作伙伴。 路易斯安那州东南部退伍军人医疗保健系统，一个新开设的大学医疗中心， 新奥尔良（10亿美元的国家投资），Ochsner健康和牙科LSUH-NO学校加入期间 周期2。洛杉矶CaTS中心正在为路易斯安那州发展一个统一的临床转化科学计划 基于创建协同计划和无与伦比的合作，从所有主要 国家的学术和生物医学研究机构。自9年前成立以来，洛杉矶猫 中心已：1）成功地利用多个参与机构的资源和专业知识， 建立一个充满活力的全州研究基础设施; 2）发展高度协同和综合 合作项目; 3）在所有机构中实施系统的临床研究方法， 包括一个新的SMART IRB依赖模型审查;以及4）实施了一个高效的 建立在合作伙伴之间前所未有的信任基础上的治理体系。洛杉矶猫正在经历 研究生产力的指数增长，通过关键指标评估，包括三倍的增长， 外部赠款奖励，作者承认LA的出版物增加了两倍多 CaTS中心的资源和服务以及600多名研究人员受益于并使用我们的服务。 值得注意的是，在新冠肺炎带来独特和前所未有的挑战的时期， 然后是飓风艾达，洛杉矶CaTS已经实现了，在许多情况下超过了，其既定的目标， 预计的里程碑。事实上，自2020年3月新型冠状病毒大流行袭击路易斯安那州以来，LA CaTS一直引领着 多次成功申请行政补助金和NOSI奖，特别是 通过RADx-UP促进服务不足的黑人社区的COVID检测和疫苗接种 计划，最近我们与IDEA国家ISCORE财团在国家 长期COVID倡议-SARS-CoV-2感染后急性后遗症（PASC）/RECOVER试验。但我们 我们充分认识到，我们的工作才刚刚开始，因为我们正在集体解决不平等问题， 我们公民的生命。同样明显的是，我们正在缓慢但肯定地影响公共卫生， 一次一个项目！随着建议的新服务和将增加的额外资源， 中心是独特的定位，致力于我们的活动和资源，我们的主要主题，为未来5- 年周期，将“解决健康差距，改善公民的健康成果， 服务”

项目成果

Implementation of a Longitudinal Critical Care Fellowship Ultrasound Curriculum.

• DOI: 10.34197/ats-scholar.2021-0120oc
• 发表时间: 2022-03
• 期刊: ATS SCHOLAR
• 影响因子: 1.9
• 作者: Young, Allison C.;Butts, Christine;DeBoisblanc, Bennett P.;Tejedor, Richard S.;Kantrow, Stephen P.;Lammi, Matthew R.
• 通讯作者: Lammi, Matthew R.

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

• DOI: 10.1016/s2468-2667(21)00302-9
• 发表时间: 2022-03
• 期刊: LANCET PUBLIC HEALTH
• 影响因子: 50
• 作者: Paluch, Amanda E.;Bajpai, Shivangi;Bassett, David R.;Carnethon, Mercedes R.;Ekelund, Ulf;Evenson, Kelly R.;Galuska, Deborah A.;Jefferis, Barbara J.;Kraus, William E.;Lee, I. -Min;Matthews, Charles E.;Omura, John D.;Patel, Alpa, V;Pieper, Carl F.;Rees-Punia, Erika;Dallmeier, Dhayana;Klenk, Jochen;Whincup, Peter H.;Dooley, Erin E.;Gabriel, Kelley Pettee;Palta, Priya;Pompeii, Lisa A.;Chernofsky, Ariel;Larson, Martin G.;Vasan, Ramachandran S.;Spartano, Nicole;Ballin, Marcel;Nordstrom, Peter;Nordstrom, Anna;Anderssen, Sigmund A.;Hansen, Bjorge H.;Cochrane, Jennifer A.;Dwyer, Terence;Wang, Jing;Ferrucci, Luigi;Liu, Fangyu;Schrack, Jennifer;Urbanek, Jacek;Saint-Maurice, Pedro F.;Yamamoto, Naofumi;Yoshitake, Yutaka;Newton Jr, Robert L.;Yang, Shengping;Shiroma, Eric J.;Fulton, Janet E.
• 通讯作者: Fulton, Janet E.

Alcohol use disorder: A pre-existing condition for COVID-19?

• DOI: 10.1016/j.alcohol.2020.10.003
• 发表时间: 2021-03
• 期刊: Alcohol (Fayetteville, N.Y.)
• 作者: Bailey KL;Samuelson DR;Wyatt TA
• 通讯作者: Wyatt TA

Mobile Health (mHealth) Technology: Assessment of Availability, Acceptability, and Use in CKD.

• DOI: 10.1053/j.ajkd.2020.10.013
• 发表时间: 2021-06
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Schrauben SJ;Appel L;Rivera E;Lora CM;Lash JP;Chen J;Hamm LL;Fink JC;Go AS;Townsend RR;Deo R;Dember LM;Feldman HI;Diamantidis CJ;CRIC Study Investigators
• 通讯作者: CRIC Study Investigators

The association between food insecurity and gun violence in a major metropolitan city.

• DOI: 10.1097/ta.0000000000003578
• 发表时间: 2022-07-01
• 期刊: The journal of trauma and acute care surgery