Louisiana Clinical and Translational Science Center - N3C supplement

路易斯安那临床和转化科学中心 - N3C 补充品

• 批准号: 10884657
• 负责人: JOHN P. KIRWAN
• 金额: $ 34.67万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10884657
• 关键词: 2019-nCoV; Academic Medical Centers; Accreditation; Acute; Address; Administrative Supplement; Alabama; Applications Grants; Award; Big Data; Biomedical Research; Black race; COVID testing; COVID-19; COVID-19 pandemic; Case Study; Center for Translational Science Activities; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communities; Country; Data; Disease; Disparity; Dose; Eligibility Determination; Evolution; Future; Genomics; Grant; Growth; Health; Health Personnel; Health Sciences; Healthcare Systems; Hospitalization; Hurricane; Individual; Infection; Inosine Dialdehyde; Institution; Institutional Review Boards; Investments; Knowledge; Laboratories; Link; Long COVID; Louisiana; Mississippi; Modeling; Monitor; Outcome; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Population; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Productivity; Public Health; Publications; RADx Underserved Populations; Records; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; School Dentistry; Services; Source; System; T-Lymphocyte Epitopes; Time; Translational Research; Trust; United States Department of Veterans Affairs; Universities; Vaccinated; Vaccination; Vaccinee; Variant; Veterans; Viral; Vulnerable Populations; West Virginia; Work; Writing; Wyoming; biomedical informatics; breakthrough infection; clinical epidemiology; clinical risk; clinical translation; cohort; collaboratory; computable phenotypes; coronavirus disease; data enclave; experience; genetic epidemiology; genomic data; health data; health disparity; home test; improved; individual patient; pandemic disease; programs; self testing; transmission process; unvaccinated; viral genomics; viral transmission

Project Summary/Abstract The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center is the lead institution and will continue to partner with Louisiana State University Health (LSUH)-New Orleans and Tulane University Health Sciences Center in this initiative. LSUH-Shreveport, LSU-A&M (Baton Rouge), Xavier University and Children's Hospital New Orleans, were early Research Partners in cycle 1. Southeast Louisiana Veterans Healthcare System, a newly opened University Medical Center in New Orleans ($1 billion State investment), Ochsner Health and the LSUH-NO School of Dentistry joined during cycle 2. The LA CaTS Center is growing a unified clinical translational science program for Louisiana based on the creation of synergistic programs and unparalleled collaboration from all the major academic and biomedical research institutions in the state. Since inception 9 years ago, the LA CaTS Center has: 1) successfully leveraged resources and expertise of multiple participating institutions to build a vibrant statewide research infrastructure; 2) developed highly synergistic and integrative collaborative programs; 3) implemented a systematic approach to clinical research across all institutions, that includes a new SMART IRB Reliance Model review; and 4) implemented a highly effective governance system based on an unprecedented level of trust between partners. LA CaTS is experiencing exponential growth in research productivity as assessed by key metrics including a three-fold increase in external grant awards, a more than two-fold increase in publications with authors acknowledging LA CaTS Center resources and services and over 600 researchers benefiting from and using our services. Notably, during a period that has been marked by unique and unprecedented challenges from COVID and then Hurricane Ida, LA CaTS has achieved, and in many cases exceeded, its stated objectives and projected milestones. Indeed, since the COVID pandemic hit Louisiana in March of 2020, LA CaTS has led multiple successful grant applications for Administrative Supplements and NOSI awards, notably to facilitate COVID testing and vaccinations in underserved Black communities through the RADx-UP program and most recently our partnership with the IDeA state ISCORE consortium on the national Long-COVID initiative - Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)/RECOVER trial. However, we fully recognize that our work has only just begun, as we collectively address disparities and improve the lives of our citizens. It is also apparent, that slowly, but surely, we are impacting public health one project at a time! With new services proposed and the additional resources that will be added, our Center is uniquely positioned to devote our activities and resources to our major theme for the next 5- year cycle that will “address health disparities and improve the health outcomes of the citizens we serve”

项目总结/文摘

项目成果

Mobile Health (mHealth) Technology: Assessment of Availability, Acceptability, and Use in CKD.

• DOI: 10.1053/j.ajkd.2020.10.013
• 发表时间: 2021-06
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Schrauben SJ;Appel L;Rivera E;Lora CM;Lash JP;Chen J;Hamm LL;Fink JC;Go AS;Townsend RR;Deo R;Dember LM;Feldman HI;Diamantidis CJ;CRIC Study Investigators
• 通讯作者: CRIC Study Investigators

Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission?

• DOI: 10.1016/j.ecl.2022.06.003
• 发表时间: 2023-02-06
• 期刊: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
• 影响因子: 4.5
• 作者: Albaugh，Vance L.;Axelrod，Christopher;Kirwan，John P.
• 通讯作者: Kirwan，John P.

The mediating effects of barriers to vaccination on the relationship between race/ethnicity and influenza vaccination status in a rural Southeastern Louisiana medical center.

• DOI: 10.15167/2421-4248/jpmh2022.63.3.2687
• 发表时间: 2022
• 期刊: Journal of preventive medicine and hygiene

Alcohol use disorder: A pre-existing condition for COVID-19?

• DOI: 10.1016/j.alcohol.2020.10.003
• 发表时间: 2021-03
• 期刊: Alcohol (Fayetteville, N.Y.)
• 作者: Bailey KL;Samuelson DR;Wyatt TA
• 通讯作者: Wyatt TA

A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study.

• DOI: 10.3389/fmolb.2021.696537
• 发表时间: 2021
• 期刊: Frontiers in molecular biosciences
• 影响因子: 5
• 作者: Liu S;Zhang B;Rowan BG;Jazwinski SM;Abdel-Mageed AB;Steele C;Wang AR;Sartor O;Niu T;Zhang Q
• 通讯作者: Zhang Q