Louisiana Clinical and Translational Science Center

路易斯安那州临床和转化科学中心

• 批准号: 10258534
• 负责人: JOHN P. KIRWAN
• 金额: $ 96.2万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-17 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258534
• 关键词: 2019-nCoV; Achievement; Address; Adult; Affect; African American; Age; Attitude; Award; Bioinformatics; Biomedical Research; Body Weight decreased; Body mass index; COVID-19; COVID-19 mortality; COVID-19 pandemic; COVID-19 testing; COVID-19 vaccine; Center for Translational Science Activities; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Church; Cities; Clinic; Clinical Sciences; Code; Collaborations; Communication; Communities; Community Participation; Coordination and Collaboration; Data; Data Reporting; Development; Diabetes Mellitus; Effectiveness; Emergency Situation; Employment; Employment Status; FDA Emergency Use Authorization; Flu virus; Focus Groups; Foundations; Future; Grant; Health; Health Status; Hospitals; Human; Hypertension; Immunization Programs; Infrastructure; Journals; Lead; Louisiana; Low income; Medical; Medicine; Mission; Multimedia; Neighborhoods; New England; Obesity; Outcome; Patients; Perception; Policies; Polymerase Chain Reaction; Population; Positioning Attribute; Premature Mortality; Prevalence Study; Public Health; Publications; RADx Underserved Populations; Race; Reporting; Research Project Grants; Resources; Reverse Transcription; Schools; Site; Societies; Socioeconomic Status; South American; System; Testing; Therapeutic; Translational Research; Underserved Population; Virus; Vulnerable Populations; Work; base; community based participatory research; community based research; community center; community clinic; community engaged research; community engagement; comorbidity; data sharing; disparity reduction; distrust; experience; falls; health disparity; health economics; improved; low socioeconomic status; novel; primary outcome; response; saliva sample; service organization; sex; social health determinants; success; testing access; testing uptake; uptake; urban underserved

Project Summary/Abstract In the US, COVID-19 has unveiled a disproportionate health burden in low income and underserved segments of society. In Louisiana, some of the greatest health and economic consequences are evident in our Black communities. There is an urgent need to establish effective testing strategies in these communities as the Fall/Winter virus surges unfold. The Louisiana Clinical and Translational Science (LA CaTS) Center provides the essential infrastructure and key foundational support for biomedical research in our region and is uniquely positioned to lead a community-engaged testing research project to determine differences in COVID-19 testing rates between community-based (churches, community centers, and schools) and medical clinic-based testing sites, and determine approaches that will increase uptake of testing in underserved Black communities in the South. We plan to address these issues using a two-pronged approach. First, we will use a community based participatory research approach to determine differences in SARS-CoV-2 testing rates across distinct types of test sites within five urban underserved Black communities in the American South. We will use a multimedia campaign to promote and conduct RT-PCR testing on salivary samples obtained from 2,000 adults at 1) medical clinics, 2) schools, 3) community centers, and 4) churches (in random order) within five ZIP codes with known low socioeconomic status (SES) and a high representation of Black residents. The primary outcome will be the number of tests performed at each type of test site. We will collect information on age, sex, race, BMI, employment, social determinants of health using an aggregate SES score to identify important correlates of testing rates. Second, we will further leverage our strong and well-integrated partnership with the Baton Rouge Mayor's Healthy City Initiative together with our LA CaTS Community Advisory Boards (CABs) to conduct community-based focus groups to obtain qualitative data about the perceptions and attitudes related to testing access and potential barriers affecting such. We will use this information to determine community-driven approaches that are effective in reducing barriers and create strategies to increase SARS-CoV-2 testing uptake in urban underserved Black communities. Results of this project will greatly increase our understanding of the factors that have led to a disproportionate COVID-19 health burden in these underserved populations and lay the groundwork for developing strategies to reduce these disparities in all underserved Black communities. Resulting data will inform the equitable deployment of future virus/flu testing and a SARS-CoV-2 vaccine.

项目摘要/摘要 在美国，新冠肺炎披露了低收入和服务不足人群不成比例的健康负担 社会的一部分。在路易斯安那州，一些最严重的健康和经济后果在我们的黑人中显而易见 社区。迫切需要在这些社区建立有效的测试战略，因为 秋季/冬季病毒激增。路易斯安那州临床和翻译科学(LA CATS)中心提供 本地区生物医学研究的基本基础设施和关键基础支持，具有独特的 能够领导一个社区参与的测试研究项目，以确定新冠肺炎测试中的差异 基于社区(教堂、社区中心和学校)的检测和基于诊所的检测之间的比率 站点，并确定将增加在服务不足的黑人社区中采用检测的方法 南。我们计划通过双管齐下的方法来解决这些问题。首先，我们将使用基于社区的 参与式研究方法确定不同地区SARS-CoV-2检测率的差异 美国南部五个服务不足的黑人社区内的考点类型。我们将使用 一项多媒体宣传活动，以推广从2,000个唾液样本中提取的唾液样本并对其进行RT-PCR检测 成人在1)医疗诊所，2)学校，3)社区中心，4)教堂(按随机顺序)在五个以内 邮政编码具有已知的低社会经济地位(SES)和高代表性的黑人居民。这个 主要结果将是在每种类型的测试地点执行的测试数量。我们将收集有关信息 年龄、性别、种族、BMI、就业、社会健康决定因素使用综合SES得分来确定 检测率的重要相关因素。第二，我们将进一步发挥我们强大和融合的 与巴吞鲁日市长的健康城市倡议以及我们的洛杉矶猫咪社区建立伙伴关系 谘询委员会(政制事务局)进行以社区为基础的焦点小组，以取得有关 与测试准入有关的看法和态度以及影响准入的潜在障碍。我们将使用这个 用于确定社区驱动的方法的信息，这些方法有效地减少障碍并创造 在服务不足的城市黑人社区提高SARS-CoV-2检测接受率的策略。结果： 这个项目将极大地提高我们对导致不成比例的新冠肺炎的因素的理解 在这些服务不足的人群中增加健康负担，并为制定战略以减少 这些差距在所有服务不足的黑人社区中都存在。由此产生的数据将为公平部署 未来的病毒/流感测试和SARS-CoV-2疫苗。