Conduct of studies to evaluate the toxic potential of thallium (I) sulfate in laboratory animals

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及在大鼠和小鼠接触饮用水后进行硫酸铊（I）的毒性研究。该化合物存在于饮用水中，因此预计人类会通过这一途径接触该化合物。此外，硫酸铊（I）可能是饮用水中其他铊化合物的代表。该项目的数据将用于对大鼠和小鼠中铊的潜在毒性得出合理的科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。 关键词：毒性，饮用水，铊

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of thallium (I) sulfate in rats and mice, following exposure in drinking water. This compound is found in drinking water and thus human exposure is anticipated via this route. In addition, thallium (I) sulfate is likely to be representative of other thallium compounds in drinking water. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of thallium in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. Keywords: toxicity, drinking water, thallium