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The Relation of Genetic Factors, Food Cues, and Self-Regulation with Excess Consumption and Adiposity in Children

The Relation of Genetic Factors, Food Cues, and Self-Regulation with Excess Consumption and Adiposity in Children
遗传因素、食物线索和自我调节与儿童过度消费和肥胖的关系
批准号:
10394896
负责人:
Diane Ihn Ae Gilbert-Diamond
金额:
$47.53万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2023-04-30

项目摘要

项目成果

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中文摘要
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英文摘要
Project Summary Childhood obesity is a critical public health problem that affects approximately 12.5 million children and teens in the United States. In our current obesogenic environment, children frequently have access to highly palatable foods such as packaged foods containing high levels of sugar, salt and fat. Importantly, most children will continue to consume highly palatable foods, even after they have eaten to satiety. This excess consumption, termed eating in the absence of hunger (EAH), is associated with child weight gain. The overarching hypothesis of the present study is that some children are genetically predisposed to EAH in response to environmental food cues, and further that self-regulatory capacity can protect children from this reward-driven overeating. The proposed aims are a major expansion of our preliminary study (1R21HD076097) in 9-10 year olds (n=172) that provides initial evidence that obesity risk alleles in the fat mass and obesity-associated (FTO) gene relate to greater EAH and brain reward-region activity in response to food cues. Our initial exploratory award led to intriguing findings that raise a number of new exciting questions and research directions. In our current expanded study, we will directly assess whether food-cue-related neural activity relates to cued EAH and adiposity gain—an outcome with critical public health significance. We will also incorporate a robust measure of self-regulatory capacity to study how this modifiable trait influences the association between neural reward activity with EAH and subsequent adiposity gain. Our expanded research will also advance our understanding of the biological mechanisms by which adiposity is affected by other known genetic obesity risk factors like melanocortin 4 receptor (MC4R) gene. This expanded study uses a comprehensive, multidisciplinary approach to increase our understanding of how genetic factors interact with environmental food cues to affect obesogenic eating behaviors in children. Most children have a very high daily exposure to external food cues. In addition to smelling and seeing actual food throughout the day, many children also experience numerous food cues in the form of TV and Internet food advertisements (ads) that can prompt cravings and EAH. Indeed, food manufacturers spend approximately 1.8 billion dollars a year marketing highly palatable foods to children under 12 years old through methods such as TV ads, Internet banner and pop-up ads, and Internet advergames. Thus, cued EAH could be an important driver of the child obesity epidemic. The study findings will have important implications for individualized child obesity intervention and prevention programs, and will also impact the public policy discourse on TV and Internet advertising of unhealthy foods to children. In a country where over one third of children are overweight or obese, it is essential to understand and systematically change environmental factors that lead to excess consumption.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.appet.2020.104610
发表时间: 2020-05-01
期刊: Appetite
影响因子: 5.4
作者: [Brand J, Masterson TD, Emond JA, Lansigan R, Gilbert-Diamond D]
通讯作者: Gilbert-Diamond D
DOI: 10.3389/fpsyg.2021.804931
发表时间: 2021
期刊: Frontiers in psychology
影响因子: 3.8
作者: [Brand J, Lansigan RK, Thomas N, Emond J, Gilbert-Diamond D]
通讯作者: Gilbert-Diamond D
Association between regional brain volumes and BMI z-score change over one year in children.
儿童一年内区域脑容量与 BMI z 分数变化之间的关联。
DOI: 10.1371/journal.pone.0221995
发表时间: 2019
期刊: PloS one
影响因子: 3.7
作者: [Masterson,TravisD, Bobak,Carly, Rapuano,KristinaM, Shearrer,GraceE, Gilbert-Diamond,Diane]
通讯作者: Gilbert-Diamond,Diane
Media multi-tasking and cued overeating: assessing the pathway and piloting an intervention using an attentional network framework
  • 批准号:
    9789910
  • 项目类别:
  • 资助金额:
    $20.5万
  • 财政年份:
    2018
  • 负责人:
    Diane Ihn Ae Gilbert-Diamond
  • 依托单位:
The Relation of Genetic Factors, Food Cues, and Self-Regulation with Excess Consumption and Adiposity in Children
  • 批准号:
    9922341
  • 项目类别:
  • 资助金额:
    $58.23万
  • 财政年份:
    2018
  • 负责人:
    Diane Ihn Ae Gilbert-Diamond
  • 依托单位:
Genetic and food advertisement influences on eating without hunger in children
  • 批准号:
    8617288
  • 项目类别:
  • 资助金额:
    $23.62万
  • 财政年份:
    2013
  • 负责人:
    Diane Ihn Ae Gilbert-Diamond
  • 依托单位:
Genetic and food advertisement influences on eating without hunger in children
  • 批准号:
    8489470
  • 项目类别:
  • 资助金额:
    $20.22万
  • 财政年份:
    2013
  • 负责人:
    Diane Ihn Ae Gilbert-Diamond
  • 依托单位:
海外基金