Relation Between In-utero Vitamin D and Immune Function in Early Childhood

宫内维生素 D 与幼儿期免疫功能的关系

• 批准号: 9234566
• 负责人: Diane Ihn Ae Gilbert-Diamond
• 金额: $ 19.24万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9234566
• 关键词: 25-hydroxyvitamin D; Adult; Affect; Allergic; Allergic rhinitis; American; Antibiotics; Asthma; Atopic Dermatitis; Biological; Biological Markers; Birth; Breast Feeding; Bronchiolitis; CD4 Positive T Lymphocytes; Characteristics; Child; Child health care; Childhood; Chronic; Classification; Cohort Studies; Confounding Factors (Epidemiology); Data; Data Collection; Diagnosis; Diet; Dose; Enrollment; Environmental Risk Factor; Epidemiology; Family; Food Hypersensitivity; Frequencies; Genetic; Genetic Polymorphism; Genotype; Gestational Age; Goals; Health; Health Care Costs; Helper-Inducer T-Lymphocyte; Hospitalization; Hypersensitivity; Immune; Immune system; Immunity; Incidence; Infant; Infection; Inflammation; Institute of Medicine (U.S.); Intake; International Unit; Interview; Lead; Life; Measures; Medical; Medical Records; Molecular Epidemiology; Morbidity - disease rate; Mothers; Multivitamin; New Hampshire; Nutritional; Obesity; Otitis Media; Outcome; Phenotype; Plasma; Play; Pneumonia; Population; Population Study; Pregnant Women; Prospective Studies; Questionnaires; Recommendation; Reporting; Research Infrastructure; Resources; Respiratory Tract Infections; Risk; Role; Schools; Socioeconomic Status; Specimen; Supplementation; Systems Development; Th1 Cells; Umbilical Cord Blood; Vitamin D; Vitamin D supplementation; Vitamin D3 Receptor; Vitamins; Wheezing; Work; allergic response; atopy; ear infection; early childhood; environmental allergy; feeding; follow-up; gastrointestinal infection; genetic profiling; high risk; immune function; in utero; instrument; mental development; middle ear; prenatal; prospective

Early childhood infection and allergies lead to substantial morbidity and health costs. Accumulating evidence suggests an important role of vitamin D in immunity. However, the studies relating vitamin D status to risk of atopy/allergy and infection in childhood are inconsistent; there are reports of both increased and decreased health risks according to vitamin D status. Moreover, there are few studies that explore the potential interaction between Vitamin D Receptor {VDR) genotypes, vitamin D status, and childhood immune outcomes. We aim to study how maternal and cord blood vitamin D concentration and infant VDR genetic profile are associated with immunity in the first three years of life within a large prospective birth cohort study. One thousand mother-child pairs are currently being enrolled in the New Hampshire Birth Cohort Study (NHBCS), a study that collects extensive data on nutritional, medical, environmental, and sociodemographic factors, as well as several biological specimens before and after delivery. The NHBCS will serve as a resource for biospecimen and data collection through questionnaires, follow-up interviews and medical record reviews. As part of the proposed study, we will measure maternal and cord blood concentrations of 25-hydroxyvitamin D (25(OH)D) and infant VDR genotypes in the NHBCS. First, we will study the associations between 25(OH)D concentrations with immune outcomes during the first 3 years of life. Atopy/allergy outcomes will include all diagnoses of atopy/allergy and specifically: atopic dermatitis, food and environmental allergies, allergic rhinitis, wheeze and asthma. Infection outcomes will include all infection diagnoses, and specifically respiratory and gastrointestinal infections. Analyses will evaluate potential confounding by factors such as gestational age at delivery, adiposity, and breast-feeding/formula feeding. Next, we will explore whether VDR polymorphisms are independently associated with the atopy/allergy and infection outcomes and whether they modify the association between maternal and cord blood 25(OH)D concentration and those outcomes. The goal of this work is to clarify the association between vitamin D status, a factor that is highly modifiable through supplementation of mothers and/or infants, with child health outcomes in the context of relevant environmental and genetic factors.

儿童早期感染和过敏会导致巨大的发病率和健康成本。积累证据 表明维生素 D 在免疫中发挥着重要作用。然而，将维生素 D 状态与以下风险相关的研究 儿童时期的特应性/过敏和感染是不一致的；据报道，有增加和减少的情况 根据维生素 D 状况的健康风险。此外，很少有研究探讨其潜力 维生素 D 受体 (VDR) 基因型、维生素 D 状态和儿童免疫之间的相互作用 结果。我们的目的是研究母体和脐带血维生素 D 浓度与婴儿 VDR 遗传的关系 在大型预期出生队列中，个人资料与生命前三年的免疫力相关 学习。目前有一千对母子正在新罕布什尔州出生队列中注册 研究 (NHBCS)，一项收集有关营养、医疗、环境和健康方面的广泛数据的研究 社会人口因素，以及分娩前后的一些生物样本。国家卫生健康委员会将 通过问卷调查、后续访谈和调查作为生物样本和数据收集的资源 医疗记录审查。作为拟议研究的一部分，我们将测量母血和脐带血 NHBCS 中 25-羟基维生素 D (25(OH)D) 的浓度和婴儿 VDR 基因型。首先，我们将 研究 25(OH)D 浓度与前 3 年免疫结果之间的关联 生活。特应性/过敏结果将包括特应性/过敏的所有诊断，特别是：特应性皮炎、食物 以及环境过敏、过敏性鼻炎、喘息和哮喘。感染结果将包括所有感染 诊断，特别是呼吸道和胃肠道感染。分析将评估潜力 诸如分娩胎龄、肥胖和母乳喂养/配方奶喂养等因素造成的混淆。 接下来，我们将探讨VDR多态性是否与特应性/变态反应独立相关。 感染结果以及它们是否改变母体和脐带血 25(OH)D 之间的关联 浓度和那些结果。这项工作的目标是阐明维生素 D 之间的关联 地位，这是一个可以通过补充母亲和/或婴儿以及儿童健康来高度改变的因素 相关环境和遗传因素的结果。