HERCULES: Exposome Research Center

项目总结-大力神：EXPOSOME研究中心 埃默里人类暴露体研究中心了解终生暴露(大力神) 环境健康核心中心的总体愿景是成为 促进和翻译曝光组研究以改善人类健康。我们的愿景是由一个 负责加强和扩展环境健康研究，促进创新和合作，参与 社区和利益相关者，并支持研究翻译，以加快影响。大力神雇佣 暴露组的框架，定义为暴露、生物反应和社会因素的总和 在一生中经历过的，这影响了个人经历的环境。大力士 成员包括来自埃默里大学和佐治亚理工学院24个系的71名研究人员 技术，通过研究暴露如何影响健康和社区的共同使命联系在一起- 并利用这些知识来改善人类健康。该中心的首要目标是) 在曝光研究的工具、应用程序和数据科学方面进行创新，b)促进和发展翻译 埃默里和佐治亚理工学院的环境健康研究，以及c)加强和扩大与 大都会亚特兰大地区社区增强其评估其曝光率和应对其 环境健康优先事项。为了实现这些目标，大力神支持综合健康科学 Facilities Core，它在目标分析工具中操作暴露组概念，非目标分析工具 高分辨率代谢组学设施，翻译研究单位，以及环境健康 数据科学核心，支持和解释多维曝光输出，提供 数据科学服务。社区参与核心通过以下方式定义和应用曝光组学 与社区团体和利益相关者进行双向互动，并领导社区计划 参与和支持。我们非常成功的试点项目项目创新了暴露研究， 优先考虑早期职业调查、翻译和社区参与研究，通过这两个更大的 传统的飞行员和规模较小、时间敏感的奖项。该中心的行政核心协调各项活动 并利用评估来确保中心目标的实现。职业发展 该计划还将支持招募到埃默里和该中心的有针对性的早期职业调查人员，并将提供 支持职业生涯早期和成熟的研究人员发展新技能或研究方向。在ITS中 愿景、目标和成员和利益相关者的多样化社区，大力神是 埃默里大学、佐治亚理工学院和亚特兰大大都会地区的环境健康研究，提供 基础设施、科学领导力和协作资源，供我们的成员开发和实施 创新曝光研究，改善人类健康。

PROJECT SUMMARY – HERCULES: EXPOSOME RESEARCH CENTER The Emory Human Exposome Research Center Understanding Lifetime ExposureS (HERCULES) Environmental Health Core Center has an overarching vision to serve as an intellectual hub in the advancement and translation of exposome research to improve human health. Our vision is shaped by a charge to enhance and extend environmental health research, foster innovation and collaboration, engage with communities and stakeholders, and support research translation to accelerate impact. HERCULES employs the framework of the exposome, defined as the totality of exposures, biological responses and societal factors experienced across a lifespan, which impact the environment experienced by an individual. HERCULES Members comprise 71 researchers from 24 departments at Emory University and the Georgia Institute of Technology, connected by a shared mission of learning how the exposome affects health and community well- being and using that knowledge to improve human health. The overarching goals of the Center are to a) innovate in the tools, application, and data science of exposome research, b) promote and grow translational environmental health research at Emory and Georgia Tech, and c) strengthen and expand partnerships with metro Atlanta area communities to enhance their ability to assess their exposome and respond to their environmental health priorities. To achieve these goals, HERCULES supports an Integrated Health Sciences Facilities Core, which operationalizes the exposome concept within a targeted analysis facility, an untargeted high resolution metabolomics facility, and translational research unit, as well as an Environmental Health Data Sciences Core to enable and interpret multidimensional exposomic output, providing an ecosystem of data sciences services. The Community Engagement Core serves to define and apply exposomics through bi-directional interactions with community groups and stakeholders and leads a program of community engagement and support. Our highly successful Pilot Project Program innovates exposome research, with priorities on early career investigators, translational, and community-engaged research through both larger traditional pilots and smaller, time-sensitive awards. The Center’s Administrative Core coordinates activities and communication and uses evaluation to ensure that the Center’s goals are achieved. A career development program also will support targeted early career investigators recruited to Emory and the Center and will provide support for both early career and established investigators to develop new skills or research directions. In its vision, aims, and diverse community of members and stakeholders, HERCULES serves as the home to environmental health research at Emory University, Georgia Tech, and the metro Atlanta area, providing infrastructure, scientific leadership, and collaborative resources for our members to develop and implement innovative exposome research and improve human health.