HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 10394106
• 负责人: Carmen Joseph Marsit
• 金额: $ 158.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394106
• 关键词: Address; Affect; Area; Award; Biological; Charge; Collaborations; Communicable Diseases; Communication; Communities; Core Facility; Data Science; Data Science Core; Ensure; Environment; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Extramural Activities; Federal Government; Fostering; Funding; Goals; Growth; Health; Health Priorities; Health Sciences; Home; Human; Individual; Infrastructure; Institutes; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Longevity; Mentorship; Mind; Mission; National Institute of Environmental Health Sciences; Nongovernmental Organizations; Output; Personal Satisfaction; Pilot Projects; Policies; Prevalence; Program Development; Public Health; Public Health Practice; Research; Research Personnel; Research Support; Resolution; Resource Development; Resources; Risk; Services; Societal Factors; Societies; Strategic Planning; Technology; Time; Translational Research; Translations; United States; Universities; Vision; Work; career; career development; climate crisis; community engaged research; community engagement; data ecosystem; data science resource; environmental health disparity; experience; holistic approach; improved; innovation; laboratory facility; member; metabolomics; metropolitan; programs; recruit; response; skills; tool; translational goal; translational pipeline

PROJECT SUMMARY – HERCULES: EXPOSOME RESEARCH CENTER The Emory Human Exposome Research Center Understanding Lifetime ExposureS (HERCULES) Environmental Health Core Center has an overarching vision to serve as an intellectual hub in the advancement and translation of exposome research to improve human health. Our vision is shaped by a charge to enhance and extend environmental health research, foster innovation and collaboration, engage with communities and stakeholders, and support research translation to accelerate impact. HERCULES employs the framework of the exposome, defined as the totality of exposures, biological responses and societal factors experienced across a lifespan, which impact the environment experienced by an individual. HERCULES Members comprise 71 researchers from 24 departments at Emory University and the Georgia Institute of Technology, connected by a shared mission of learning how the exposome affects health and community well- being and using that knowledge to improve human health. The overarching goals of the Center are to a) innovate in the tools, application, and data science of exposome research, b) promote and grow translational environmental health research at Emory and Georgia Tech, and c) strengthen and expand partnerships with metro Atlanta area communities to enhance their ability to assess their exposome and respond to their environmental health priorities. To achieve these goals, HERCULES supports an Integrated Health Sciences Facilities Core, which operationalizes the exposome concept within a targeted analysis facility, an untargeted high resolution metabolomics facility, and translational research unit, as well as an Environmental Health Data Sciences Core to enable and interpret multidimensional exposomic output, providing an ecosystem of data sciences services. The Community Engagement Core serves to define and apply exposomics through bi-directional interactions with community groups and stakeholders and leads a program of community engagement and support. Our highly successful Pilot Project Program innovates exposome research, with priorities on early career investigators, translational, and community-engaged research through both larger traditional pilots and smaller, time-sensitive awards. The Center’s Administrative Core coordinates activities and communication and uses evaluation to ensure that the Center’s goals are achieved. A career development program also will support targeted early career investigators recruited to Emory and the Center and will provide support for both early career and established investigators to develop new skills or research directions. In its vision, aims, and diverse community of members and stakeholders, HERCULES serves as the home to environmental health research at Emory University, Georgia Tech, and the metro Atlanta area, providing infrastructure, scientific leadership, and collaborative resources for our members to develop and implement innovative exposome research and improve human health.

项目概要- HERCULES：暴露体研究中心 埃默里人类暴露体研究中心了解终生暴露S（HERCULES） 环境健康核心中心有一个总体愿景，作为一个知识中心， 促进和转化棘手的研究，以改善人类健康。我们的愿景是由 负责加强和扩大环境健康研究，促进创新和合作， 社区和利益相关者，并支持研究翻译，以加速影响。HERCULES雇用 麻烦组的框架，定义为暴露、生物反应和社会因素的总和 在整个生命周期中所经历的，影响个人所经历的环境。Hercules 成员包括来自埃默里大学24个系和格鲁吉亚研究所的71名研究人员。 技术，通过共同的使命连接起来，了解疾病如何影响健康和社区， 并利用这些知识来改善人类健康。该中心的总体目标是： 创新的工具，应用，和数据科学的麻烦的研究，B）促进和增长的翻译 埃默里大学和格鲁吉亚理工大学的环境健康研究，以及c）加强和扩大与 亚特兰大大都会地区的社区，以提高他们的能力，以评估他们的麻烦，并作出回应， 环境卫生优先事项。为了实现这些目标，HERCULES支持综合健康科学 设施核心，在有针对性的分析设施内实施麻烦的概念， 高分辨率代谢组学设施，转化研究单位，以及环境卫生 数据科学核心，以实现和解释多维数据经济输出，提供一个生态系统， 数据科学服务。社区参与核心通过以下方式定义和应用生态经济学： 与社区团体和利益相关者进行双向互动，并领导社区计划 参与和支持。我们非常成功的试点项目计划创新了棘手的研究， 优先考虑早期职业调查员，翻译和社区参与的研究，通过两个更大的 传统的飞行员和较小的、时间敏感的奖励。中心的行政核心协调活动 和沟通，并使用评估，以确保该中心的目标实现。职业发展 该计划还将支持有针对性的早期职业调查人员招募到埃默里和中心，并将提供 支持早期职业和成熟的研究人员发展新的技能或研究方向。在其 愿景，目标和多元化的社区成员和利益相关者，HERCULES作为家庭， 埃默里大学、格鲁吉亚理工学院和亚特兰大市区的环境健康研究， 基础设施、科学领导力和协作资源，供我们的成员开发和实施 创新性研究和改善人类健康。