Enriching the Rhode Island Child Health Study

丰富罗德岛州儿童健康研究

• 批准号: 10594309
• 负责人: Carmen Joseph Marsit
• 金额: $ 39.32万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594309
• 关键词: Acceleration; Age; Ancillary Study; Award; Behavioral; Biological; Birth; Chemicals; Child; Child Health; Clinical; Cohort Studies; Collaborations; Collection; Communities; Data; Data Analyses; Data Collection; Data Scientist; Data Set; Development; Disease; Disease Outcome; Diverse Workforce; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Epidemiologist; Epidemiology; Epigenetic Process; Faculty; Fellowship; Female; Funding; Future; Genomics; Goals; Grant; Growth; Health; Infant; Infrastructure; Investments; K-Series Research Career Programs; Link; Maintenance; Massachusetts; Measures; Mediating; Minority Groups; Molecular; Molecular Biology; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Outcome; Participant; Peer Review; Placenta; Placental Biology; Positioning Attribute; Postdoctoral Fellow; Pregnancy; Productivity; Psychologist; Public Policy; Publications; R24; Regulation; Research; Research Assistant; Research Personnel; Resources; Rhode Island; Risk Assessment; Role; Sampling; Scientist; Seminal; Sleep; Source; Structural Racism; System; Training; U-Series Cooperative Agreements; Underrepresented Populations; United States National Institutes of Health; Variant; Work; biobank; cardiometabolism; career; cohort; community engaged research; critical period; data management; data sharing; disorder risk; early childhood; environmental enrichment for laboratory animals; epigenetic variation; epigenomics; experience; follow-up; genomic data; innovation; marginalized population; method development; neurobehavioral; next generation; novel; offspring; open data; population based; post-doctoral training; postnatal; prenatal; prospective; recruit; social; social determinants; social epidemiology; social health determinants; structural determinants; structural health determinants; tool; validation studies

PROJECT SUMMARY/ABSTRACT This U24 renewal is a cooperative agreement responsive to RFA-ES-22-001, “Maintaining and Enriching Environmental Epidemiology Cohorts to Support Scientific and Workforce Diversity.” Our overarching goal is to sustain, enrich and diversify resource infrastructure for the Rhode Island Children’s Health Study (RICHS; Marsit, Stroud MPI: R24ES028507) by facilitating future longitudinal follow-up, accelerating data man- agement and sharing, and diversifying the scientific workforce. RICHS was developed to characterize the impact of the environment on newborn and early childhood health outcomes with a novel and unique focus on the mechanistic role of placenta molecular function in mediating the impact of the chemical, physical, social, and behavioral environment on infant/child health and disease. The cohort is comprised of 840 mother-infant pairs from the Rhode Island and Southeastern Massachusetts region enrolled using a population-based recruitment strategy. RICHS offspring at the start of this project range in age from 8.8-13.8 years—a critical period for envi- ronmental influences on development. Data and results from the cohort have made seminal contributions to elucidating (a) the fundamental molecular biology of the placenta, (b) the impact of environmental exposures on placental epigenetic and genomic regulation, (c) links between placental molecular variation and newborn growth and neurobehavioral outcomes, as well as (d) novel methods development. Resources/investigators from the RICHS cohort contributed to 75 publications (42 during the R24 period), 10 NIH grants including fellowship and career development awards for early career scientists, and >20 post/doctoral projects. The proposed U24 infra- structure support will facilitate prospective, longitudinal assessments of novel child health and disease outcomes, postnatal environmental exposures, structural and social determinants of health, as well as continued collection of biospecimens into the RICHS biorepository. The U24 will also support enrichment of data management and broad sharing of cohort resources, with all activities aimed at providing opportunities for a diverse cadre of sci- entists across career stages to access to data and biospecimens to develop novel research questions. Specifi- cally, the goals of this R24 infrastructure support project are to (1) support the infrastructure of diverse workforce of the cohort, (2) continue to obtain longitudinal data on mother-child pairs, (3) broaden the diversity of RICHS by facilitating enrollment of new participants from complementary Rhode Island cohorts, (4) refine and expand systems for broad sharing of cohort data and resources, (5) increase opportunities for scholars from historically under-represented groups to engage with the RICHS cohort, and (6) work with the consortium in developing integrated measures and common strategies for data sharing and collaboration. Ultimately, U24 infrastructure support will maximize NIEHS investment by increasing diversity of participants, workforce, and measures in this highly unique and productive cohort, accelerating discovery and catalyzing future transformative contributions to children’s environmental health.

项目总结/摘要 本次U24更新是响应RFA-ES-22-001“维护和丰富 环境流行病学群组支持科学和劳动力多样性。我们的总体 目标是维持、丰富和多样化罗得岛儿童健康研究的资源基础设施 （RICHS; Marsit，Stroud MPI：R24 ES 028507）通过促进未来的纵向随访，加速数据管理， 共享和多样化的科学劳动力。RICHS是为了描述 环境对新生儿和幼儿健康结果的影响， 胎盘分子功能在介导化学、物理、社会和 行为环境对婴幼儿健康和疾病的影响。该队列由840对母婴组成 来自罗得岛和东南部马萨诸塞州地区的研究人员使用基于人口的招募方法招募 战略RICHS的后代在这个项目开始时的年龄范围从8.8-13.8岁-一个关键时期的环境， 对发展的影响。该队列的数据和结果为以下方面做出了开创性贡献： 阐明（a）胎盘的基本分子生物学，（B）环境暴露对 胎盘表观遗传和基因组调控，（c）胎盘分子变异和新生儿生长之间的联系 和神经行为结果，以及（d）新方法的开发。资源/调查员 RICHS队列贡献了75篇出版物（R24期间42篇），10项NIH赠款，包括奖学金和 为早期职业科学家提供职业发展奖，以及超过20个博士后/博士项目。建议的U24基础设施 结构化支持将促进对新的儿童健康和疾病结果的前瞻性、纵向评估， 产后环境暴露、健康的结构和社会决定因素以及持续收集 送到RICHS生物储存库U24还将支持丰富的数据管理， 广泛共享群组资源，所有活动都旨在为不同的科学骨干提供机会， 跨职业阶段的实体访问数据和生物标本，以开发新的研究问题。具体- 总的来说，R24基础设施支持项目的目标是：（1）支持不同劳动力的基础设施 （2）继续获取母子对的纵向数据，（3）扩大RICHS的多样性 通过促进补充罗得岛队列的新参与者的注册，（4）完善和扩展 广泛共享队列数据和资源的系统，（5）增加历史学者的机会 代表性不足的群体参与RICHS队列，以及（6）与联盟合作开发 数据共享和协作的综合措施和共同战略。最终，U24基础设施 支持将通过增加参与者、劳动力的多样性， 在这个高度独特和富有成效的群体中采取措施，加速发现并催化未来 对儿童环境健康的变革性贡献。